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Accuracy of magnetic resonance imaging in diagnosing thyroid cartilage and thyroid gland invasion by squamous cell carcinoma in laryngectomy patients

Published online by Cambridge University Press:  11 January 2012

A J Kinshuck ,
P W A Goodyear ,
J Lancaster ,
N J Roland ,
S Jackson ,
R Hanlon ,
H Lewis-Jones ,
J Sheard  and
T M Jones
A J Kinshuck*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
P W A Goodyear
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
J Lancaster
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
N J Roland
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
S Jackson
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK
R Hanlon
Affiliation:
Department of Radiology, University Hospital Aintree, Liverpool, UK
H Lewis-Jones
Affiliation:
Department of Radiology, University Hospital Aintree, Liverpool, UK
J Sheard
Affiliation:
Department of Pathology, University Hospital Aintree, Liverpool, UK
T M Jones
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Liverpool, UK Liverpool CR-UK Centre, School of Cancer Studies, University of Liverpool, UK
*
Address for correspondence: Mr A J Kinshuck, Department of Otolaryngology and Head and Neck Surgery, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK E-mail: [email protected]
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Abstract

Objectives:

We examined the accuracy of magnetic resonance imaging in assessing thyroid cartilage and thyroid gland invasion in patients undergoing total laryngectomy for squamous cell carcinoma, by comparing histopathology results with imaging findings.

Study design:

A retrospective study reviewed histology and magnetic resonance scan results for all total laryngectomies performed between 1998–2008 at University Hospital Aintree, Liverpool.

Methods:

Pre-operative magnetic resonance images were reviewed independently by two consultant head and neck radiologists masked to the histology; their opinions were then compared with histology findings.

Results:

Eighty-one magnetic resonance scans were reviewed. There were 22 laryngectomy patients with histologically verified thyroid cartilage invasion and one patient with thyroid gland invasion. There were 31 patients with apparent radiological thyroid cartilage invasion pre-operatively (with 17 false positives), giving sensitivity, specificity, and positive and negative predictive values of 64, 71, 45 and 84 per cent, respectively. On assessing thyroid gland invasion, there were nine false positive scans and no false negative scans, giving sensitivity, specificity, and positive and negative predictive values of 100, 89, 10 and 100 per cent, respectively.

Conclusion:

Magnetic resonance scanning over-predicts thyroid cartilage and gland invasion in patients undergoing total laryngectomy. Magnetic resonance scans have limited effectiveness in predicting thyroid cartilage invasion by squamous cell carcinoma in laryngectomy patients.

Keywords

Total LaryngectomyMRI scansThyroid CartilageThyroid Gland
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 3 , March 2012 , pp. 302 - 306
Copyright
Copyright © JLO (1984) Limited 2012

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