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Absence of Epstein-Barr virus encoded RNA and latent membrane protein (LMP1) in salivary gland neoplasms

Published online by Cambridge University Press:  29 June 2007

A. M. Pollock ,
M. Toner ,
M. McMenamin ,
J. Walker  and
C. I. Timon
A. M. Pollock*
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
M. Toner
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland Department of Otolaryngology – Head and Neck Surgery, St. James's Hospital, Dublin, Ireland
M. McMenamin
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
J. Walker
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
C. I. Timon
Affiliation:
Department of Oral Surgery, Medicine and Pathology, Dublin Dental Hospital, Dublin, Ireland
*
Address for correspondence: Dr Anne Marie Pollock, Histopathology Department, Royal Victoria Infirmary, Queen Victoria Street, Newcastle-upon-Tyne NE1 4LP
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Abstract

A series of 55 (42 benign and 13 malignant) salivary gland tumours were investigated by immunohistochemistry, to detect Epstein-Barr virus (EBV) latent membrane protein (LMP1) and by in situ hybridization for EBV-encoded RNA. Non-neoplastic gland from all the patients with tumours and 15 control glands were also examined. All cases, both neoplastic and non-neoplastic were negative for LMP1 and failed to show any positive signal by in situ hybridization for EBV RNA. One undifferentiated carcinoma from a European patient was included in the group. These results confirm previous reports of an ethnic association between EBV and undifferentiated carcinomas of the salivary gland. They do not support an aetiological role for EBV in other salivary gland tumours.

Keywords

Herpesvirus 4, humanHybridizationSalivary glands
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 10 , October 1999 , pp. 906 - 908
Copyright
Copyright © JLO (1984) Limited 1999

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References

Biggar, R. J., Curtis, R. E., Hoffman, D. A., Flannery, J. T. (1983) Second primary malignancies following salivary gland cancers. British Journal of Cancer 47: 383–386.CrossRefGoogle ScholarPubMed
Chan, J. K., Yip, T. C., Tsang, W. Y., Poon, Y. F., Wong, C. S., Ma, V. S. (1994) Specific association of Epstein-Barr virus with lymphoepithelial carcinoma among tumours and tumour-like lesions of the salivary gland. Archives of Pathology and Laboratory Medicine 118: 994–997.Google Scholar
Deacon, E. M., Matthews, J. B., Potts, A. J. C., Hamburger, J., Bevan, I. S., Young, L. S. (1991) Detection of Epstein Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjögren's syndrome. Journal of Pathology 163: 351–360.CrossRefGoogle ScholarPubMed
Epstein, M. A., Achong, B. G., Barr, Y. M. (1964) Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet i: 702–703.CrossRefGoogle Scholar
Fox, J. D., Briggs, M., Ward, P. A., Tedder, R. S. (1990) Human herpesvirus 6 in salivary glands. Lancet 336: 590–593.CrossRefGoogle ScholarPubMed
Gerber, P., Lucas, S., Nonoyama, M., Perlin, E., Goldstein, L. (1972) Oral secretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. Lancet ii: 988–989.CrossRefGoogle Scholar
Hamilton-Dutoit, S. J., Hamilton, Therkildsen M., Nielson, N. H., Jensen, H., Hansen, J. P. H., Pallesen, G. (1991) Undifferentiated carcinoma of the salivary gland in Green-landic Eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Human Pathology 22: 811–815.CrossRefGoogle Scholar
Hellquist, H. B., Karlsson, M. G., Nilsson, C. (1994) Salivary duct carcinoma: a highly aggressive salivary gland tumour with overexpression of c-erbB2. Journal of Pathology 172: 35–44.CrossRefGoogle Scholar
Huang, D. P., Ng, H. K., Ho, Y. H., Chan, K. M. (1988) Epstein-Barr virus associated undifferentiated carcinoma of the parotid gland. Histopathology 13: 509–517.CrossRefGoogle ScholarPubMed
Karajannis, M. A., Hummel, M., Anagnostopoulos, I., Stein, H. (1997) Strict lymphotropism of Epstein-Barr virus during acute infectious mononucleosis in non-immunocompro-mised individuals. Blood 89: 2856–2862.CrossRefGoogle Scholar
Kärjä, V., Syrjänen, K., Syrjänen, S. (1997) No Epstein-Barr and cytomegalovirus DNA found in salivary gland tumours. ORL 59: 97–99.CrossRefGoogle ScholarPubMed
Leung, S. Y., Chung, L. P., Yuen, S. T., Ho, C. M., Wong, M. P., Chan, S. Y. (1995) Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. Journal of Clinical Pathology 48: 1022–1027.CrossRefGoogle ScholarPubMed
Lopategui, J. R., Gaffey, M. J., Frierson, H. F., Chan, J. K., Mills, S. E., Chang, K. L., Chen, Y. Y., Weiss, L. M. (1994) Detection of Epstein-Barr viral RNA in sinonasal undifferentiated carcinoma from Western and Asian patients. American Journal of Surgical Pathology 18: 391–398.CrossRefGoogle ScholarPubMed
Muller, S., Vigneswaran, N., Gansler, T., Gramlich, T., DeRose, P. B., Cohen, C. (1994) c-erbB2 oncoprotein expression and amplification in pleomorphic adenoma: Relationship to prognosis. Modern Pathology 7: 628–632.Google Scholar
Prevot, S., Hamilton-Dutoit, S., Audoin, J., Walter, P., Pallesen, G., Diebold, J. (1992) Analysis of African Burkitt's and high-grade B cell non-Burkitt's lymphoma for Epstein-Barr virus genomes using in situ hybridization. British Journal of Haematology 80: 27–32.CrossRefGoogle ScholarPubMed
Prior, P., Waterhouse, J. A. H. (1977) Second primary cancer in patients with tumours of the salivary glands. British Journal of Cancer 36: 362–368.CrossRefGoogle ScholarPubMed
Santucci, M., Gallo, O., Calzolari, A., Bondi, R. (1993) Detection of Epstein-Barr viral genome in tumour cells of Warthin's tumour of parotid gland. American Journal of Clinical Pathology 100: 662–665.CrossRefGoogle Scholar
Spitz, M. R., Tilley, B. C., Batsakis, J. G., Gibeau, J. M., Newell, G. R. (1984) Risk factors for major salivary gland carcinoma. A case comparison study. Cancer 54: 1854–1859.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Taira, S., Okuda, M., Osato, T., Mizuno, F. (1992) Detection of Epstein-Barr virus DNA in salivary gland tumours. Nippon Jibiinkoka Gakkai Kaiho 92: 860–868.CrossRefGoogle Scholar
Takeiche, N., Hirose, F., Yamamoto, H., Ezaki, H., Fujikura, T. (1983) Salivary gland tumours in atomic bomb survivors Hiroshima Japan. Cancer 52: 377–385.3.0.CO;2-9>CrossRefGoogle Scholar
Weiland, L. H. (1988) Non-lymphoid tissues induced by or associated with herpesvirus. Journal of Virological Methods 21: 73–78.CrossRefGoogle ScholarPubMed
Weiss, L. M., Movahed, L. A., Warnke, R. A., Sklar, J. (1989) Detection of Epstein-Barr viral genomes in Reed Sternberg cells of Hodgkin's disease. New England Journal of Medicine 320: 502–506.CrossRefGoogle ScholarPubMed