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Vestibular effects of intravenous lidocaine used in the treatment of tinnitus

Published online by Cambridge University Press:  29 June 2007

Saumil N. Merchant  and
Milind V. Kirtane
Saumil N. Merchant
Affiliation:
Resident in Otolaryngology.
Milind V. Kirtane*
Affiliation:
Professor of Otolarygology and Chief of Neurotology.
*
Dr. M.V. Kirtane, Gokul, Tejpal Road, Bombay 400007, India.
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Abstract

Intravenous lidocaine is known to have an effect on the auditory system in that it is useful for suppressing tinnitus, albeit temporarily. We have used intravenously administered lidocaine as one of the treatment modalities for refractory, disturbing, tinnitus. Its effects on the vestibulo-ocular system were determined by elec-tronystagmography performed before and immediately after injecting lidocaine: smooth pendular stimulus tracking was unaffected; spontaneous and positional nystagmus tended to be suppressed; directional preponderance was reduced or reversed; and the difference between the nystagmus responses in the two directions during the pendular rotation chair test was also reduced or reversed. These changes in the caloric and rotation tests were statistically significant. Lidocaine also appeared to have altered the balance between the two sides in the vestibulo-spinal system as indicated by the results of the stepping test during craniocorpography. The results lend support to the hypothesis that intravenous lidocaine acts at the level of the central nervous system rather than at the periphery.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 11 , November 1986 , pp. 1249 - 1253
Copyright
Copyright © JLO (1984) Limited 1986

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References

Claussen, C. F. and DeSa, J. V. (1978) In Clinical study of human equilibrium by electronystagmography and allied tests, Popular Prakashan, Bombay, pp. 115–123.Google Scholar
Claussen, C. F. and Schlachta, I. V. (1972) Butterfly chart for caloric nystagmus evaluation. Archives of Otolaryngology, 96: 371–375.CrossRefGoogle ScholarPubMed
de Jong, R. H., Robles, R. and Corbin, R. W. (1969) Central actions of lidocaine—synaptic transmission. Anaesthesiology, 30: 19–23.CrossRefGoogle ScholarPubMed
Donaldson, I. (1981) Tegretol: A double blind trial in tinnitus. Journal of Laryngology and Otology, 95: 947–951.CrossRefGoogle ScholarPubMed
Emmett, J. R. and Shea, J. J. (1980) Treatment of tinnitus with tocainide hydrochloride. Otolaryngology, Head and Neck Surgery, 88: 442–446.CrossRefGoogle ScholarPubMed
Englesson, S., Larsson, B., Lindquist, N. G., Lyttkens, L. and Stahle, J. (1976) Accumulation of 14C- Lidocaine in the inner ear: Preliminary clinical experience utilizing intravenous lidocaine in the treatment of severe tinnitus. Acta Otolaryngologica (Stockholm), 82: 297–300.CrossRefGoogle ScholarPubMed
Gejrot, T. (1963) Intravenous Xylocaine in the treatment of attacks of Menière's disease. Acta Otolaryngologica (Stockholm), Supplement 188: 190–195.Google Scholar
Gejrot, T. (1976) Intravenous Xylocaine in the treatment of attacks of Menière's disease. Acta Otolaryngologica (Stockholm), 82: 301–302.CrossRefGoogle ScholarPubMed
Israel, J. M., Connelly, J. S., McTigue, S. T., Brummett, R. E. and Brown, J. (1982) Lidocaine in the treatment of tinnitus aurium. A double blind study. Archives of Otolaryngology, 108: 471–473.CrossRefGoogle ScholarPubMed
Jongkees, L. B. W. and Philiphzoon, A. J. (1964) Electronystagmography. Acta Otolaryngologica (Stockholm), Supplement 189: 45–46.Google ScholarPubMed
Kirtane, M. V. (1979) Standardization in electronystagmography. Indian Journal of Otolaryngology 31: 126–132.CrossRefGoogle Scholar
Kirtane, M. V. (1982) In Electronystagmography—a systematic approach. M. V. Kirtane, Bombay, pp. 54–62.Google Scholar
Kirtane, M. V., Medikeri, S. B. and Merchant, S. N. (1983) Craniocorpography—a modified technique, to be published in the Proceedings of the Neurootological and Equilibriometric Society Reg., Volume XI.Google Scholar
Melding, P. S. and Goodey, R. J. (1979) The treatment of tinnitus with oral anticonvulsants. Journal of Laryngology and Otology, 93: 111–122.CrossRefGoogle ScholarPubMed
Melding, P. S., Goodey, R. J. and Thorne, P. R. (1978) The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. Journal of Laryngology and Otology, 92: 115–121.CrossRefGoogle ScholarPubMed
Shea, J. J. and Harell, M. (1978) Management of tinnitus aurium with lidocaine and carbamazepine. Laryngoscope, 88: 1477–1484.CrossRefGoogle ScholarPubMed
Unterberger, S. (1938) Neue objectiv registrierbare estibularis—Körper—drehreaktion, erhalten, durch Treten (Kehlkheilkunde) auf der Stelle. Der “Tretversuch”. Archiv für Ohren, Nasen und Kehlkeilkunde, 145: 478–492.CrossRefGoogle Scholar