Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-24T13:47:42.219Z Has data issue: false hasContentIssue false
  • English
  • Français

Value of lymph node biopsy in the diagnosis of acquired toxoplasmosis

Published online by Cambridge University Press:  29 June 2007

Nukhet Tuzuner ,
Gülen Doǧusoy ,
Cuyan Demirkesen ,
Ferda Ozkana  and
Kemal Altas
Nukhet Tuzuner
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Gülen Doǧusoy*
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Cuyan Demirkesen
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Ferda Ozkana
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Kemal Altas
Affiliation:
Department of Microbiology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
*
Address for correspondence: Gülen Doǧusoy, Cerrahpaşa Tip Fakültesi, Patoloji ABD, Aksaray, Istanbul, Turkey. Fax: 0212 632 00 50
Get access Rights & Permissions [Opens in a new window]

Abstract

Toxoplasmic lymphadenitis generally involves a solitary lymph node in the head and neck regions, without systemic symptoms. In order to determine the frequency of toxoplasmic lymphadenitis, we reviewed the histological sections of 731 consecutive patients with reactive lymph node hyperplasia. Amongst 731 patients, 112 had histological features supporting a diagnosis of toxoplasmic lymphadenitis (15.3 per cent). In 80 of these patients (71 per cent), either Indirect Haemaglutination test (IHA), in 37 cases, or the Enzyme-Linked Immunosorbent Assay (ELISA) for detecting toxoplasmic IgG or IgM antibodies, in 43 cases, were performed. In 76 out of 80 patients (95 per cent), histological features correlated well with serological studies. The IHA test was positive in 30 patients with a titre of 1/64 or higher. The IgG-ELISA test was positive in 11 whereas the IgM-ELISA test was positive in 28 patients. These results provide further evidence of the distinctive nature of the histological changes in toxoplasmic lymphadenitis, which should enable the clinician to make a confident diagnosis of acute acquired toxoplasmosis.

Keywords

Toxoplasmosis, acquiredLymph nodesBiopsy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 4 , April 1996 , pp. 348 - 352
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dorfman, R. F., Remington, J. S. (1973) Value of lymph node biopsy in the diagnosis of acute acquired toxoplasmosis. New England Journal of Medicine 289: 878–881.Google Scholar
Elliot, D. L., Tolle, S. W., Goldberg, L., Miller, J. B. (1985). Pet-associated illness. New England Journal of Medicine 313: 985–995.Google Scholar
Frenkal, J. K. (1985) Symposium on parasitic infections: Toxoplasmosis. Pediatric Clinics of North America 32: 917–932.CrossRefGoogle Scholar
Gray, G. F. Jr, Kimball, A. C., Kean, B. H. (1975) The posterior cervical lymph node in toxoplasmosis. American Journal of Pathology 28: 42–49.Google Scholar
Johnson, A. M., Gu, Q. M., Roberts, H. (1987) Antibody patterns in the serological diagnosis of acute lymphadenopathic toxoplasmosis. Australia, New Zealand Journal of Medicine 17: 430–434.Google Scholar
Knobber, D., Schetzle, W. (1987) Lymphadenitis toxoplasmatica. Laryngo-Rhino-Otologie (Stuttgart) 66: 70–72.CrossRefGoogle Scholar
Lunde, M. N. (1973) Laboratory methods in the diagnosis of toxoplasmosis. Health and Laboratory Science 10: 319–328.Google Scholar
McCabe, R. E., Brooks, R. G., Dorfman, R. F., Remington, J. S. (1987) Clinical spectrum in 107 cases of toxoplasmic lymphadenitis. Pathology Review of Infectious Disease 9: 754–774.Google Scholar
Naot, Y., Remington, J. S. (1980) An enzyme-linked immunoabsorbent assay for detection of IgM antibodies to Toxoplasma gondü: use for diagnosis of acute acquired toxoplasmosis. Journal of Infectious Diseases 142: 457–766.CrossRefGoogle Scholar
Ozcan, K. (1981) Detection of latent toxoplasmosis in healthy individuals by using indirect hemaglutination (IHA). Bulletin of Microbiology 15: 121–129.Google Scholar
Pringer-Kuchinga, A., Martin, I., Thalhammer, O. (1958) Uber die vorzuglich cervico-nuchale lymphadenitis mit kleinherdiger epthelioidzell. Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizina 131: 522–535.Google Scholar
Rafaty, F. M. (1977) Cervical adenopathy secondary to toxoplasmosis. Archives of Otolaryngology 103: 547–549.Google Scholar
Remington, J. S., Desmonts, G. (1973) Congenital toxoplasmosis: variability in the IgM fluorescent antibody response and some pitfalls in the diagnosis. Journal of Pediatrics 83: 27–30.Google Scholar
Sadauddin, A., Agha, F., Anwar, F., Ghafoor, A. (1991) Seroepidemiology of Toxoplasma gond¨ infection in young school children in Islamabad. Journal of Pakistan Medical Association 41: 131–134.Google Scholar
Sauerbrei, A., Wutzler, P., Pfister, W., Kaiser, U., Schreiber, D., Rudiger, K. D. (1990) Microbiological and morphological findings in reactive lymphadenopathy. Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie 136: 419–425.Google ScholarPubMed
Saxen, E., Saxen, L., Gronroos, P. (1958) Glandular toxoplasmosis a report on 23 histologically diagnosed cases. Acta Pathologica Scandinavica 44: 319–328.CrossRefGoogle Scholar
Seidal, J. S. (1985) Protozoal infections. Pediatric Clinics of North America 32: 1064–1067.Google Scholar
Stansfeld, A. G. (1961) The histologic diagnosis of toxoplasmic lymphadenitis. Journal of Clinical Pathology 14: 565–573.CrossRefGoogle ScholarPubMed
Symmers, W. St. C. (1992) Lymphadenitis caused by infection and infestation. In Thymus, Lymph Nodes, Spleen and Lymphatics, Systemic Pathology, 3rd Edition, (Henry, K., Symmers, W. St. C, eds.). Churchill Livingstone, Edinburgh, pp 438–446.Google Scholar
Welch, C., Masur, H., Jones, T. C., Remington, J. S. (1980) Serological diagnosis of acute lymphadenopathic toxoplasmosis. Journal of Infectious Diseases 142: 256–264.CrossRefGoogle ScholarPubMed
Wielaard, F., van Grvijthvijsen, H., Dvermeyer, W., Jess, A. W. L., Skinner, L., Williams, H., van Elven, E. H. (1983) Diagnosis of acute toxoplasmosis by an enzyme immunoassay for specific immunoglobulin M antibodies. Journal of Clinical Microbiology 17: 981–987.Google Scholar