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Undifferentiated carcinoma of the nasopharynx and leukemoid reaction: report of case with literature review

Published online by Cambridge University Press:  29 June 2007

Sven Saussez ,
P. Heimann ,
Luc Vandevelde ,
Pierre Bisscnop ,
Albert Jortay ,
Liliane Schandene  and
Elie Cogan
Sven Saussez*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Hôpital Erasme, Free University of Brussels (U.L.B.), Brussels, Belgium.
P. Heimann
Affiliation:
Department of Pathology, Hôpital Brugmann, Free University of Brussels (U.L.B.), Brussels, Belgium.
Luc Vandevelde
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Hôpital Brugmann, Free University of Brussels (U.L.B.), Brussels, Belgium.
Pierre Bisscnop
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Hôpital Brugmann, Free University of Brussels (U.L.B.), Brussels, Belgium.
Albert Jortay
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Hôpital Brugmann, Free University of Brussels (U.L.B.), Brussels, Belgium.
Liliane Schandene
Affiliation:
Department of Immunology, Hôpital Erasme, Free University of Brussels (U.L.B.), Brussels, Belgium.
Elie Cogan
Affiliation:
Department of Medicine, Hôpital Erasme, Free University of Brussels (U.L.B.), Brussels, Belgium.
*
Address for correspondence: Dr S. Saussez, Department of Otolaryngology, Hôpital Erasme, 808 Route de Lennik, 1070 Brussels, Belgium. Fax: 32-2-555.68.26
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Abstract

A case of undifferentiated carcinoma of the nasopharynx presenting as a cervical mass associated with a paraneoplastic neutrophilic leukemoid reaction is reported. The diagnosis of undifferentiated nasopharyngeal carcinoma of the Regaud type was established by the presence of aggregates of epithelial neoplastic cells separated by areas of reactive lymphoid cells; the epithelial nature being confirmed by the positivity for epithelial markers (AE1/AE3, EMA). Serum IL-la, GM-CSF and TNFα remained undetectable suggesting that these factors were not involved in the occurrence of the paraneoplastic leukemoid syndrome.

Keywords

Nasopharyngeal neoplasmsCarcinomaParaneoplastic syndromesLeukemoid reaction
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 1 , January 1997 , pp. 66 - 69
Copyright
Copyright © JLO (1984) Limited 1997

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