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Ultrastructure of nasal mast cells in normal subjects and patients with perennial allergic rhinitis

Published online by Cambridge University Press:  29 June 2007

A. B. Drake-Lee  and
Jaqueline Price
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Abstract

The ultrastructure of mast cells from the nine normal inferior turbinates were compared with those found in eight patients with perennial allergic rhinitis due to house dust mite allergy. Forty-six mast cells from normal patients were found in forty blocks and eighty cells were found in thirty-three blocks in patients with perennial allergy suggesting an increase of mast cell numbers in perennial allergy. There were no basophils outside the blood vessels and whole mast cells were found only in the submucosa. There was no difference in the morphology of cells of different sizes. Mast cells were more degranulated in the allergic mucosa. Degranulation, irrespective of cell size was found at all depths of the mucosa. A review of the literature covered the in vivo and in vitro descriptions of the ultrastructural morphology of human mast cells in the respiratory tract.

Keywords

RhinitsallergicMast cellElectron microscopy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 1006 - 1013
Copyright
Copyright © JLO (1984) Limited 1991

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References

Behrent, H, Rosenkranz, U, Schmutter, W. (1978) Ultrastructure of isolated human mast cells during histamine release with Ionophore A23187. International Archives of Allergy and Applied Immunology 56: 188–192.CrossRefGoogle Scholar
Busuttil, A, More, I, McGeveny, D. (1976) Ultrastructure of the stroma of nasal polyps. Archives of Otolaryngology 102: 589–595.CrossRefGoogle ScholarPubMed
Caulfield, J, Lewis, R, Hein, A, Austin, K. (1980) Secretions in dissociated human pulmonary mast cells. Journal of Cell Biology 85: 299–311.CrossRefGoogle ScholarPubMed
Cauna, N, Hindover, K, Manzethi, G, Swanson, E. (1972) Fine structure of nasal polyps. Archives of Otolaryngology 81: 41–58.Google ScholarPubMed
Craig, S, Schechtern, N, Schwartz, L. (1988) Ultrastructural analysis of human T and TC mast cells identified by electron microscopy. Laboratory Investigation 58: 682–691.Google Scholar
Drake-Lee, A, Barker, T, Thurley, K. (1984) Nasal polyps II. Fine structure of mast cells. Journal of Laryngology and Otology 98: 285–292.CrossRefGoogle Scholar
Drake-Lee, A, Price, J, Milford, C, Bickerton, R. (1987) Nasal mast cells: a preliminary report on their ultrastructure. Journal of Laryngology and Otology 101: Supplement 13.CrossRefGoogle Scholar
Enerback, L, Pipkorn, U, Granurus, G. (1986) Intraepithelial mast cells in hay fever. International Archives of Allergy and Applied Immunology 80: 44–51.CrossRefGoogle ScholarPubMed
Fox, B, Bull, T, Guz, A. (1981) Mast cells in the human alveolar wall: an electron microscopy study. Journal of Clinical Pathology 34: 1333–1342.CrossRefGoogle Scholar
Friedman, M, Kaliner, M. (1985) In situ degranulation of human nasal mucosal mast cells: ultrastructural features and cell associations Journal of Allergy and Clinical Immunology 76: 70–82.CrossRefGoogle ScholarPubMed
Fujita, H, Asagami, C, Murozumi, S, Yamamoto, K, Kinoshita, K. (1969) Electron microscopic studies of mast cells of human skin. Journal of Ultrastructural Research 28: 353–370.CrossRefGoogle Scholar
Galli, S, Dvorak, A, Dvorak, H. (1984) Basophils and mast cells: morphological insights into their biology, secretory patterns and function. Progress in Allergy (Ishizaka, K Ed) Vol. 34 Karger: Basle.Google Scholar
Kawabori, S, Okuda, M, Unno, T. (1983) Mast cells in allergic nasal epithelium and lamina propria before and after provocation. Clinical Allergy 13: 181–189.CrossRefGoogle ScholarPubMed
Kawanami, O, Ferrans, V, Fulmer, J, Crystal, R. (1979) Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders. Laboratory Investigations 6: 717–730.Google Scholar
Mygind, N. (1978) Nasal Allergy. Blackwell Scientific Publications: Oxford.Google Scholar
Naclerio, R, Togias, A, Proud, D Kagey-Sobotka, A, Adkinson, N, Norman, P, Lichenstein, L. (1985) The measurement of inflammatory mediators in nasal secretions. Immunobiology, Autoimmunity and Transplantation in Otorhinolaryngology. (Veldman, J. Ed) Kugler Publications: Amsterdam p. 273–278.Google Scholar
Okuda, M, Ohtsuka, H, Kawabori, S. (1985) Basophil leukocytes and mast cells in the nose European Journal of Respiratory Diseases 64: Supplement 128. 7–14.Google Scholar
Okuda, M, Ohtsuka, H. (1987). Heterogeneity of the human nasal mast cell. In Immunobiology, Histophysiology, Tumor Immunology in Otorhinolaryngology (Veldman, J., ed) Kugler Publications; Amsterdam p. 317–323.Google Scholar
Reynolds, E. (1963) The use of lead citrate at high pH as an electron opaque stain in electron microscopy. Journal of Cell Biology 17: 208–213.CrossRefGoogle ScholarPubMed
Spurr, A. (1969) A low viscosity resin medium for electron microscopy. Journal of Ultrastructural Research. 26: 31–43.CrossRefGoogle ScholarPubMed
Trotter, C, Orr, T. (1973) A fine structure study of some cellular components in allergic reactions. Clinical Allergy 3: 411–425.CrossRefGoogle ScholarPubMed
Ts'ao, C, Patterson, R, McKenna, J, Suszko, I. (1977) Ultrastructural identification of mast cells obtained from human bronchial lumens. Journal of Allergy and Clinical Immunology 59: 320–326.CrossRefGoogle ScholarPubMed
Viegas, M, Gomes, E, Brooks, J, Gatland, D, Davies, R. (1987) Effect of the pollen season in nasal mast cells. British Medical Journal. 414.CrossRefGoogle ScholarPubMed