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Treatment results for ethmoid sinus carcinoma

Published online by Cambridge University Press:  03 August 2009

J R Gras-Cabrerizo ,
J R Montserrat-Gili ,
X León-Vintró ,
H Massegur-Solench ,
J M de Vega  and
D Virós-Porcuna
J R Gras-Cabrerizo*
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
J R Montserrat-Gili
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
X León-Vintró
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
H Massegur-Solench
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
J M de Vega
Affiliation:
Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
D Virós-Porcuna
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain
*
Address for correspondence: Dr Juan R Gras-Cabrerizo, Department of Otolaryngology/Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. E-mail: [email protected]
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Abstract

Objective:

The aim of this study was to describe the results of treatment in patients with ethmoid sinus carcinoma.

Materials and method:

We performed a retrospective study of 34 patients with carcinoma of the ethmoid sinus, and collected the following data: age, sex, employment, tobacco and alcohol consumption, tumour-node-metastasis stage, treatment, and survival.

Results:

The mean patient age was 64 years. Seventy-six per cent of patients were men and 24 per cent women. Squamous cell carcinoma was the most frequent histological tumour type (44 per cent). Eleven patients were classified as T2, six as T3, six as T4a and 11 as T4b. Two patients (6 per cent) had nodal metastasis at the time of diagnosis. The anterior skull base was involved in 17 patients (50 per cent) and the anterior orbital contents were affected in seven patients (21 per cent). The five-year actuarial observed survival rate for all patients was 44 per cent.

Conclusions:

Combined treatment with surgery and post-operative radiotherapy permitted good local control in patients with ethmoid sinus carcinoma. We do not recommend prophylactic neck treatment for ethmoid sinus carcinoma.

Keywords

Ethmoid SinusesCarcinomaParanasal Sinus NeoplasmsSurgeryRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 10 , October 2009 , pp. 1120 - 1124
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Dulguerov, P, Jacobsen, MS, Allal, AS, Lehmann, W, Calcaterra, T. Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review. Cancer 2001;92:3012–293.0.CO;2-E>CrossRefGoogle ScholarPubMed
2Osguthorpe, JD. Sinus neoplasia. Arch Otolaryngol Head Neck Surg 1994;120:19–25CrossRefGoogle ScholarPubMed
3Myers, LL, Nussenbaum, B, Bradford, CR, Teknos, TN, Esclamado, RM, Wolf, GT. Paranasal sinus malignancies: an 18-year single institution experience. Laryngoscope 2002;112:1964–9CrossRefGoogle ScholarPubMed
4Papadimitrakopoulou, VA, Ginsberg, LE, Garden, AS, Kies, MS, Glisson, BS, Diaz, EM Jr et al. Intraarterial cisplatin with intravenous paclitaxel and ifosfamide as an organ-preservation approach in patients with paranasal sinus carcinoma. Cancer 2003;98:2214–23CrossRefGoogle ScholarPubMed
5Waldron, J, Witterick, I. Paranasal sinus cancer: caveats and controversies. World J Surg 2003;27:849–55CrossRefGoogle ScholarPubMed
6Tufano, RP, Mokadam, NA, Montone, KT, Weinstein, GS, Chalian, AA, Wolf, PF et al. Malignant tumors of the nose and paranasal sinuses: hospital of the University of Pennsylvania experience 1990–1997. Am J Rhinol 1999;13:117–23CrossRefGoogle ScholarPubMed
7Grau, C, Jakobsen, MH, Harbo, G, Svane-Knudsen, V, Wedervang, K, Larsen, SK et al. Sino-nasal cancer in Denmark 1982-1991 – a nationwide survey. Acta Oncol 2001;40:19–23Google Scholar
8Gras Cabrerizo, JR, Orus Dotu, C, Montserrat Gili, JR, Fabra Llopis, JM, Leon Vintro, X, De Juan Beltran, J. Epidemiologic analysis of 72 carcinomas of the nasal cavity and paranasal sinuses [in Spanish]. Acta Otorrinolaringol Esp 2006;57:359–63CrossRefGoogle ScholarPubMed
9Sobin, LH, Wittekind, CH, eds. International Union Against Cancer. TNM Classification of Malignant Tumours, 5th edn.New York: Wiley-Liss, 1997Google Scholar
10Sobin, LH, Wittekind, CL, eds. TNM Classification of Malignant Tumours, 6th edn.New York: John Wiley, 2002Google Scholar
11León, X, Orús, C, Quer, M. Design, maintenance, and exploitation of an oncologic database for patients with malignant tumors of the head and neck [in Spanish]. Acta Otorrinolaringol Esp 2002;53:185–90CrossRefGoogle ScholarPubMed
12Waldron, JN, O'Sullivan, B, Warde, P, Gullane, P, Lui, FF, Payne, D et al. Ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. Int J Radiat Oncol Biol Phys 1998;41:361–9CrossRefGoogle ScholarPubMed
13Logue, JP, Slevin, NJ. Carcinoma of the nasal cavity and paranasal sinuses: an analysis of radical radiotherapy. Clin Oncol 1991;3:84–9CrossRefGoogle ScholarPubMed
14Bhattacharyya, N. Factors predicting survival for cancer of the ethmoid sinus. Am J Rhinol 2002;16:281–6CrossRefGoogle ScholarPubMed
15Alvarez, I, Suarez, C, Rodrigo, JP, Nunez, F, Caminero, MJ. Prognostic factors in paranasal sinus cancer. J Otolaryngol 1995;16:109–14Google ScholarPubMed
16Knegt, PP, Ah-See, KW, vd Velden, LA, Kerrebijn, J. Adenocarcinoma of the ethmoidal sinus complex: surgical debulking and topical fluorouracil may be the optimal treatment. Arch Otolaryngol Head Neck Surg 2001;127:141–6CrossRefGoogle ScholarPubMed
17Nuñez, F, Suarez, C, Alvarez, I, Losa, JL, Barthe, P, Fresno, M. Sino-nasal adenocarcinoma: epidemiological and clinico-pathological study of 34 cases. J Otolaryngol 1993;22:86–90Google Scholar
18O'Sullivan, B, Shah, J. New TNM staging criteria for head and neck tumors. Semin Surg Oncol 2003;21:30–42CrossRefGoogle ScholarPubMed
19Patel, SG, Singh, B, Polluri, A, Bridger, PG, Cantu, G, Cheesman, AD et al. Craniofacial surgery for malignant skull base tumors: report of an international collaborative study. Cancer 2003;98:1179–87CrossRefGoogle ScholarPubMed
20Cantu, G, Solero, CL, Mariani, L, Salvatori, P, Mattavelli, F, Pizzi, N et al. Anterior craniofacial resection for malignant ethmoid tumors – a series of 91 patients. Head Neck 1999;21:185–913.0.CO;2-8>CrossRefGoogle ScholarPubMed
21Uchida, D, Shirato, H, Onimaru, R, Endou, H, Aoyama, H, Tsuchiya, K et al. Long-term results of ethmoid squamous cell or undifferentiated carcinoma treated with radiotherapy with or without surgery. Cancer J 2005;11:152–6CrossRefGoogle ScholarPubMed
22Tiwari, R, Hardillo, JA, Tobi, H, Mehta, D, Karim, AB, Snow, G. Carcinoma of the ethmoid: results of treatment with conventional surgery and post-operative radiotherapy. Eur J Surg Oncol 1999;25:401–5CrossRefGoogle ScholarPubMed
23Stoll, D, Bebear, JP, Truilhe, Y, Darrouzet, V, David, N. Ethmoid adenocarcinomas: retrospective study of 76 patients. Rev Laryngol Otol Rhinol 2001;122:21–9Google ScholarPubMed
24Claus, F, Boterberg, T, Ost, P, Huys, J, Vermeersch, H, Braems, S et al. Postoperative radiotherapy for adenocarcinoma of the ethmoid sinuses: treatment results for 47 patients. Int J Radiat Oncol Biol Phys 2002 15;54:1089–94CrossRefGoogle Scholar
25Salvan, D, Julieron, M, Marandas, P, Janot, F, Leridant, AM, Domenge, C et al. Combined transfacial and neurosurgical approach to malignant tumours of the ethmoid sinus. J Laryngol Otol 1998;112:446–50CrossRefGoogle ScholarPubMed
26Jiang, GL, Morrison, WH, Garden, AS, Geara, F, Callender, D, Goepfert, H et al. Ethmoid sinus carcinomas: natural history and treatment results. Radiother Oncol 1998;49:21–7CrossRefGoogle ScholarPubMed