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Topical active H1-antihistamines and their effect on nasal airway resistance

Published online by Cambridge University Press:  29 June 2007

R. J. van Houten  and
D. J. Premachandra
R. J. van Houten
Affiliation:
Department of Otolaryngology, James Paget Hospital, Gorleston, Great Yarmouth, Norfolk NR31 6LA, UK.
D. J. Premachandra*
Affiliation:
Department of Otolaryngology, James Paget Hospital, Gorleston, Great Yarmouth, Norfolk NR31 6LA, UK.
*
Mr D. J. Premachandra, Department of ENT Surgery, James Paget Hospital, Gorleston, Great Yarmouth, Norfolk NR31 6LA.
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Abstract

The introduction of a topically active H1-antihistamine nasal spray Azelastine, has given an extra dimension in the management of allergic rhinits. The drug acts rapidly and avoids the sustemic adverse effects of antihistimines. An objective prospective study was performed to detect the effect of Azelastine nasal spray on nasal airway resistance. Twelve healthy adult volunteers with no rhinological problems were included in the study. Nasal cavites were sprayed with 280 μg (two puffs) of Azelastine nasal spray and the nasal airway resistance was measured with anterior rhinomanometry at intervals of 30 minutes for up to two hours. Our study has shown statistically significant increase in the total nasal airway resistance following the use orf Azelastine nasal spray in the absence of a subjective change in nasal airway resistance. There are substances when inhaled which can cause subjective improvement in nasal airway patency without changing the measured nasal airway resistance. However this medication gives no subjective change in nasal airway patency in spite of increasing nasal airway resistance.

Keywords

Histamine H1 receptor blockadersNose
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 9 , September 1995 , pp. 841 - 843
Copyright
Copyright © JLO (1984) Limited 1995

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References

Burrow, A., Eccles, R., Jones, A. A. (1983) The effect of camphor, eucalyptus and menthol vapour on nasal resistance to airflow and nasal sensation. Acta Otolaryngologica (Stockholm) 96: 157–161.CrossRefGoogle ScholarPubMed
Clement, P. A. R. (1984) Committee report on standardization of rhinomanometry. Rhinology 22: 151–155.Google ScholarPubMed
Jackson, R. T. (1991) Mechanism of action of some commonly used nasal drugs. Otolaryngology-Head and Neck Surgery 104: 433–440.CrossRefGoogle ScholarPubMed
Naclerio, R. M., Kagey-Sobotka, A., Lichtenstein, L. M., Freidhoff, L., Proud, D. (1990) Terfenadine, an H1 antihistamine, inhibitis histamine release in vivo in the human. American Review of Respiratory Disease 142: 167–171.CrossRefGoogle Scholar
Nolte, D., Kurzeja, A. H., Gastpar, H. (1989) Comparison of the efficacy and tolerability of an azelastine Hcl nasal spray with those of terfenadine on six-weeks treatment of patients with allergic rhinitis. Study numbers of 2606, 2610 and 2613 respectively. Product Monograph Rhinolast 24–26.Google Scholar
Togias, A. G., Naclerio, R. M., Warner, J., Proud, D., KageySobotka, A., Nimmagadda, I., Noramn, P. S., Lichtenstein, L. M. (1986) Demonstration of inhibition of mediator release from mast cells bny azatadine: in vivo and in vitro evaluation. Journal of the American Medical Association 255: 225–229.CrossRefGoogle Scholar
Wight, R. G., Jones, A. S., Clegg, R. T. (1988) A comparison of anterior and radical trimming of the inferior nasal turbinates and the effects on nasal resistance to airflow. Clinical Otolaryngology 12: 223–226.CrossRefGoogle Scholar