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Technetium–99m(v) Dimercaptosuccinic acid planar scintigraphy in head and neck cancer: Clinical, scintigraphic and radiological study

Published online by Cambridge University Press:  29 June 2007

J. C. Watkinson ,
C. E. C. Todd ,
C. R. Lazarus ,
M. N. Maisey  and
S. E. M. Clarke
J. C. Watkinson*
Affiliation:
Departments of otolaryngology, Guy's Hospital, London. Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
C. E. C. Todd
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
C. R. Lazarus
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
M. N. Maisey
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
S. E. M. Clarke
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
*
J. C. Watkinson M.Sc, F.R.C.S., Department of Otolaryngology, Guy's Hospital, St. Thomas' Street, London SE1 9RT.
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Abstract

Technetium-99m (Tc99m)(v) Dimercaptosuccinic Acid (DMSA) is animaging agent which has been proposed as a scintigraphic marker for head and neck squamous cell carcinoma. Fifty-four patients were studied of whom 51 had a head and neck tumour. All patients were examined and then imaged using Tc99m(v) DMSA scintigraphy and computerized tomography.

Scintigraphy was less sensitive than clinical examination in the detection of patients with cancer, patients with primary tumours and patients with metastatic neck disease. CT was as sensitive and as accurate as clinical examination but more senstive than Tc99m(v) DMSA in detecting patients with cancer and with primary tumours. CT was more sensitive and more accurate than both clinical examination and Tc99m(v) DMSA scintigraphy in predicting which patients had metastatic neck disease.

Although Tc99m(v) DMSA is accumulated by squamous cell carcinoma, its inability to detect low volume disease and apparent low specificity means it has no role to play in the management of patients with head and neck squamous cell carcinoma.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 10 , October 1990 , pp. 783 - 789
Copyright
Copyright © JLO (1984) Limited 1990

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References

Blakeslee, D. B., Becker, G. D., Simpson, G. T., Patten, D. H., Sprengelmeyer, T. (1985) Lymphoscintigraphy of the neck. Otolaryngology Head and Neck Surgery, 93: 361–365.CrossRefGoogle ScholarPubMed
Clarke, S. E., Lazarus, C. R., Wraight, P., Sampson, C., Maisey, M. N. (1988) Pentavalent 99mTc DMSA, 131I MIBG and 99mTc MDP–An evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid. Journal of Nuclear Medicine, 29: 33–38.Google ScholarPubMed
Cummings, C. W., Larson, S. M., Dobie, R. A.,Weymuller, E. A. Jr, Rudd, T. G., Merello, A. (1981) Assessment of Cobalt 57 Tagged Bleomycin as a clinical aid in staging of head and neck carcinoma. Laryngoscope, 91: 529–537.CrossRefGoogle ScholarPubMed
Edwards, C. L., Hayes, R. L. (1969) Tumor scanning with 67Ga-Citrate. Journal of Nuclear Medicine, 10: 103–105.Google Scholar
Feinmesser, R., Freeman, J. L., Noyek, A. M.,Birt, B. D. (1987) Metastatic neck disease: A clinicaLfradiographic/pathologic correlative study. Archives of Otolaryngology Head and Neck Surgery, 113: 1307–1310.CrossRefGoogle ScholarPubMed
Friedman, M., Shelton, V. K., Mafee, M., Bellity, P., Grybauskas, V., Skolnick, E. (1984) Metastatic neck disease. Evaluation by Computed Tomography. Archives of Otolaryngology, 110: 443–447.CrossRefGoogle ScholarPubMed
Mancuso, A. A., Hanafee, W. N. (1985) Computed Tomography and Magnetic Resonance imaging of the head and neck (2nd Edn). Williams and Wilkins: Baltimore.Google Scholar
Ohta, H., Endo, K., Fujita, T., Kowishi, J., Horiuchi, K., Yokoyama, A. (1988) Clinical evaluation of tumour imaging using 99Tc(v)m dimercaptosuccinic acid, a new tumour-seeking agent. Nuclear Medicine Communications, 9: 105–116.Google ScholarPubMed
Sampson, C. B. (1987) Preparation of 99Tcm(v) DMSA. Nuclear Medicine Communications, 8: 184–185.Google Scholar
Som, P. M. (1987) Lymph nodes of the neck. Radiology, 165: 593–600.CrossRefGoogle ScholarPubMed
Soo, K. C., Ward, M., Roberts, K. R., Keeling, F., Carter, R. L., McCready, V. R., Ott, R. J., Powell, E., Ozanne, B., Westwood, J. H.,Gusterson, B. A. (1987) Radioimmunoscintigraphy of squamous carcinomas of the head and neck. Head and Neck Surgery, 9: 349–352.CrossRefGoogle ScholarPubMed
Stevens, M. H., Hamsberger, H. R., Mancuso, A. A., Davis, R. K., Johnson, L. P., Parkin, J. L. (1985) Computed Tomography of cervical lymph nodes. Staging and management of head and neck cancer. Archives of Otolaryngology, 111: 735–739.CrossRefGoogle ScholarPubMed
Teates, C. D., Preston, D. F., Boyd, C. M. (1980) Gallium-67 Citrate imaging in head and neck tumors: Report of co-operative group. Journal of Nuclear Medicine, 21: 622–627.Google Scholar
Watkinson, J. C., Lazarus, C. R., Mistry, R.,Shaheen, O. H., Maisey, M. N., Clarke, S. E. (1989a) Technetium–99m(v) Dimercaptosuccinic Acid uptake in patients with head and neck squamous carcinoma: Experience in imaging. Journal of Nuclear Medicine, 30: 174–180.Google ScholarPubMed
Watkinson, J. C., Lazarus, C. R., Maisey, M. N. and Clarke, S. E. M., (1989b) 99Tcm(v)DMSA planar scintigraphy–Does it have a role in the management of patients with head and neck squamous carcinoma? Nuclear Medicine Communications, 10: 859–870.CrossRefGoogle ScholarPubMed
Watkinson, J. C., Allen, S., Lazarus, C. R., Maisey, M. N., Clarke, S. E. M. (1989c) What is the optimal imaging time for 99Tcm(v) DMSA planarscintigraphy in the detection of squamous carcinoma? A comparative study in humans and in an animal tumour model. Nuclear Medicine Communications, 10:741–750.CrossRefGoogle Scholar
Watkinson, J. C., Johnston, D., Jones, N., Coady, M., Laws, D., Allen, S., Hibbert, J., (1989d) The reliability of palpation in the assessment of tumours. Clinical Otolaryngology (in press).CrossRefGoogle Scholar
Watkinson, J. C., Todd, C. E. C., Paskin, L.,Rankin, S., Palmer, T., Shaheen, O. H., Clarke, S. E. M., (1989e). Metastatic carcinoma in the neck: A clinical, radiological, scintigraphic and pathological study. Clinical Otolaryngology (in press).Google Scholar