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Somatostatin receptor imaging of olfactory neuroblastoma

Published online by Cambridge University Press:  29 June 2007

Hans A. Ramsay ,
Kalevi J. A. Kairemo  and
Antti P. Jekunen
Hans A. Ramsay*
Affiliation:
Departments of Otolaryngology, University Hospital of Helsinki, Finland.
Kalevi J. A. Kairemo
Affiliation:
Department of Oncologyt, University Hospital of Helsinki, Finland.
Antti P. Jekunen
Affiliation:
Department of Oncologyt, University Hospital of Helsinki, Finland.
*
Address for correspondence: Hans A. Ramsay, M.D., ENT department, University Hospital, Haartmansstreet 4E, FIN-00290 Helsinki, Finland. Fax: +358-9-4715010.
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Abstract

Neural-crest tumours, including neuroblastomas, express somatostatin receptors. This can be shown by radionuclide labelling of octreotide, a somatostatin analogue. Studies on imaging with this substance have dealt with childhood neuroblastomas. Olfactory neuroblastoma (aesthesioneuroblastoma) is a rare tumour in which somatostatin receptor content has not been analysed, nor have radionuclide methods for diagnostic purposes been described. We report a case of olfactory neuroblastoma, in which scanning with m In-labelled octreotide was performed. A strong uptake was seen at the base of the skull. This was confirmed as a recurrent tumour by magnetic resonance (MR) imaging. Uptake was also observed in the neck and chest, indicating extensive spread of the disease.

Somatostatin receptor expression has been shown to correlate with prognosis in childhood neuroblastoma. The accuracy of labelled octreotide in the diagnosis of olfactory neuroblastoma indicates that it might be useful in radionuclide therapy of patients with advanced disease, when no other treatment modalities are available.

Keywords

SomatostatinOctreotideNeuroblastoma, olfactory
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 12 , December 1996 , pp. 1161 - 1163
Copyright
Copyright © JLO (1984) Limited 1996

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