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Small cell neuroendocrine carcinoma of larynx: case series and literature review

Published online by Cambridge University Press:  15 July 2015

Muhammad Shahid Iqbal ,
V Paleri ,
J Moor ,
W Dobrowsky ,
C Kelly  and
J Kovarik
Muhammad Shahid Iqbal*
Affiliation:
Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcaslte upon Tyne, UK
V Paleri
Affiliation:
Department of Otolaryngology, Freeman Hospital, Newcastle upon Tyne, UK
J Moor
Affiliation:
Department of Otolaryngology, Sunderland Royal Hospital, UK
W Dobrowsky
Affiliation:
Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcaslte upon Tyne, UK
C Kelly
Affiliation:
Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcaslte upon Tyne, UK
J Kovarik
Affiliation:
Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcaslte upon Tyne, UK
*
Address for correspondence: Dr Muhammad Shahid Iqbal, Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK Fax: +44 191 2137691 E-mail: [email protected]
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Abstract

Background:

Primary small cell neuroendocrine carcinoma of larynx is a rare, aggressive type of malignancy. As only about 200 cases worldwide have been reported, any larger institutional experience is valuable. This study reports our experience in managing this rare entity.

Methods:

Of the nine patients identified, three had metastatic cancer at the time of diagnosis. Four patients underwent radical treatment: one was managed surgically followed by adjuvant chemotherapy and consolidation radiotherapy; the remaining three were treated with neoadjuvant chemotherapy and definitive radiotherapy.

Results:

Of the 4 patients treated with radical intent, 1 was alive and disease free after 99 months, 2 died of metastatic disease after 22 and 26 months, and 1 was alive after 20 months with a diagnosis of recurrent disease.

Conclusion:

Our relatively small number of patients confirms other centres' experiences. This cancer has a poorer prognosis than most other head and neck cancers. Although the logistics would be challenging, there is a need for international multicentre trials for this disease modelled on those performed for other cancers, as has been done for paediatric malignancies.

Keywords

NeuroendocrineSmall Cell CarcinomaLarynxChemotherapyRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 9 , September 2015 , pp. 910 - 915
Copyright
Copyright © JLO (1984) Limited 2015 

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References

1Laryngeal cancer statistics. Cancer Research UK. In: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/laryngeal-cancer [accessed 22 June 2014]Google Scholar
2Ferlito, A, Silver, CE, Bradford, CR, Rinaldo, A. Neuroendocrine neoplasms of the larynx: an overview. Head Neck 2009;31:1634–46CrossRefGoogle ScholarPubMed
3Renner, G. Small cell carcinoma of the head and neck: a review. Semin Oncol 2007;34:3–14CrossRefGoogle ScholarPubMed
4Hatoum, GF, Patton, B, Takita, C, Abdel-Wahab, M, LaFave, K, Weed, D et al. Small cell carcinoma of the head and neck: the university of Miami experience. Int J Radiat Oncol Biol Phys 2009;74:477–81CrossRefGoogle ScholarPubMed
5Lobins, R, Floyd, J. Small cell carcinoma of unknown primary. Semin Oncol 2007;34:39–42CrossRefGoogle ScholarPubMed
6Ferlito, A, Rinaldo, A. Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. Head Neck 2008;30:518–24CrossRefGoogle ScholarPubMed
7van der Heijden, HF, Heijdra, YF. Extrapulmonary small cell carcinoma. South Med J 2005;98:345–9CrossRefGoogle ScholarPubMed
8Mikić, A, Zvrko, E, Trivić, A, Stefanović, D, Golubović, M. Small cell neuroendocrine tumor of the larynx – a small case series. Coll Antropol 2012;36 Suppl 2:201–4Google ScholarPubMed
9Barnes, L, Eveson, J, Reichart, P, Sidransky, D. Pathology and Genetics of Head and Neck Tumours. World Health Organization Classification of Tumours. Lyon: IARC Press, 2005Google Scholar
10Olofsson, J, Van Nostrand, AW. Anaplastic small cell carcinoma of larynx. Case report. Ann Otol Rhinol Laryngol 1972;81:284–7CrossRefGoogle ScholarPubMed
11Gripp, FM, Risse, EK, Leverstein, H, Snow, GB, Meijer, CJ. Neuroendocrine neoplasms of the larynx. Importance of the correct diagnosis and differences between atypical carcinoid tumors and small-cell neuroendocrine carcinoma. Eur Arch Otorhinolaryngol 1995;252:280–6CrossRefGoogle ScholarPubMed
12Gnepp, DR. Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:210–19CrossRefGoogle ScholarPubMed
13Jiang, L, Yang, KH, Guan, QL, Mi, DH, Wang, J. Cisplatin plus etoposide versus other platin-based regimens for patients with extensive small-cell lung cancer: a systematic review and meta-analysis of randomised, controlled trials. Intern Med J 2012;42:1297–309CrossRefGoogle ScholarPubMed
14Galanis, E, Frytak, S, Lloyd, RV. Extrapulmonary small cell carcinoma. Cancer 1997;79:1729–363.0.CO;2-#>CrossRefGoogle ScholarPubMed
15Ferlito, A, Pesavento, G, Recher, G, Caruso, G, Dal Fior, S, Montaguti, A, Carraro, R, Narne, S, Pennelli, N. Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. Auris Nasus Larynx 1986;13:113–23CrossRefGoogle ScholarPubMed
16Barker, JL Jr, Glisson, BS, Garden, AS, El-Naggar, AK, Morrison, WH, Ang, KK et al. Management of nonsinonasal neuroendocrine carcinomas of the head and neck. Cancer 2003;98:2322–8CrossRefGoogle ScholarPubMed
17Baugh, RF, Wolf, GT, McClatchey, KD. Small cell carcinoma of the head and neck. Head Neck Surg 1986;8:343–54CrossRefGoogle ScholarPubMed
18Bahar, G, Nageris, BI, Spitzer, T, Popovtzer, A, Mharshak, G, Feinmesser, R. Subglottic carcinoma [in Hebrew]. Harefuah 2002;141:914–18, 929Google ScholarPubMed
19Gnepp, DR, Ferlito, A, Hyams, V. Primary anaplastic small cell (oat cell) carcinoma of the larynx. Review of the literature and report of 18 cases. Cancer 1983;51:1731–453.0.CO;2-6>CrossRefGoogle ScholarPubMed
20Soga, J, Ferlito, A, Rinaldo, A. Endocrinocarcinomas (carcinoids and their variants) of the larynx: a comparative consideration with those of other sites. Oral Oncol 2004;40:668–72CrossRefGoogle ScholarPubMed
21Ferlito, A, Rinaldo, A. Small cell neuroendocrine carcinoma of the larynx: a preventable and frustrating disease with a highly aggressive lethal behavior. ORL J Otorhinolaryngol Relat Spec 2003;65:131–3CrossRefGoogle ScholarPubMed
22Turrisi, AT 3rd, Kim, K, Blum, R, Sause, WT, Livingston, RB, Komaki, R et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 1999;340:265–71CrossRefGoogle ScholarPubMed
23Weng, CT, Chu, PY, Liu, MT, Chen, MK. Small cell carcinoma of the head and neck: a single institution's experience and review of the literature. J Otolaryngol Head Neck Surg 2008;37:788–93Google ScholarPubMed
24Baugh, RF, Wolf, GT, Beals, TF, Krause, CJ, Forastiere, A. Small cell carcinoma of the larynx: results of therapy. Laryngoscope 1986;96:1283–90CrossRefGoogle ScholarPubMed
25van der Laan, TP, Plaat, BE, van der Laan, BF, Halmos, GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases. Head Neck 2015;37:707–15CrossRefGoogle ScholarPubMed