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Sex ratios in otosclerotic families

Published online by Cambridge University Press:  29 June 2007

W. H. James
W. H. James*
Affiliation:
London
*
Dr William H. James, Ph.D., MRC Mammalian Development Unit, Wolfson House, (University College London), 4 Stephenson WayLondon NW1 2HE
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Abstract

The sex ratio (proportion of males) of offspring of otosclerotics is significantly and substantially below expectation. To account for this and other features of the condition, it has been suggested elsewhere that otosclerosis is subject to autosomal dominant transmission with intrauterine selection against male heterozygotes. To test this hypothesis, a search was made for published data on the sexes of sibs of otosclerotics. These sibs do not have an unusual sex ratio, thus casting doubt on the hypothesis. Accordingly it is suggested here that both the condition and the sex ratios are causally related to levels of steroid hormones.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 11 , November 1989 , pp. 1036 - 1039
Copyright
Copyright © JLO (1984) Limited 1989

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