Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-26T22:02:34.991Z Has data issue: false hasContentIssue false

Samter's triad with aural involvement: a novel approach to management

Published online by Cambridge University Press:  24 November 2014

P Sethukumar*
Affiliation:
Department of Otolaryngology, St. Mary's Hospital Paddington, Imperial College Healthcare NHS Trust, London, UK
R Heywood
Affiliation:
Department of Otolaryngology, St. Mary's Hospital Paddington, Imperial College Healthcare NHS Trust, London, UK
A Narula
Affiliation:
Department of Otolaryngology, St. Mary's Hospital Paddington, Imperial College Healthcare NHS Trust, London, UK
*
Address for correspondence: Miss P Sethukumar, Department of Otolaryngology, St. Mary's Hospital, Paddington, London W2 1NY, UK E-mail: [email protected]

Abstract

Background:

Samter's triad is a well described condition manifesting as chronic rhinosinusitis with nasal polyposis, asthma and aspirin intolerance in a non-atopic individual. The underlying mechanism is still to be fully elucidated. However, aural disease has not been widely reported in these patients. In the few reported cases, most patients underwent major surgery with varying degrees of success.

Case report:

We report two Samter's triad patients with aural involvement. Both were successfully managed by conservative treatment, thus avoiding the need for major surgery. It appears that more Samter's triad patients may have aural disease than previously thought.

Conclusion:

We report good outcomes with conservative treatment, which is relevant because aural disease tends to reoccur in these patients.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Samter, M, Beers, RF Jr.Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 1968;68:975–83Google Scholar
2Widal, F, Abrami, P, Lermoyez, J. Anaphylaxis and idiosyncrasy [in French]. Allergy Proc 1993;14:373–6Google Scholar
3Samter, M, Beers, RF Jr.Concerning the nature of intolerance to aspirin. J Allergy 1967;40:281–93CrossRefGoogle ScholarPubMed
4Brobst, R, Suss, N, Joe, S, Redleaf, S. Bilateral inflammatory aural polyps: a manifestation of Samter's triad. Int J Otolaryngol 2009;2009:464958.Google Scholar
5Ying, S, Meng, Q, Scadding, G, Parikh, A, Corrigan, CJ, Lee, TH. Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 expression on nasal mucosal inflammatory cells. J Allergy Clin Immunol 2006;117:312–18Google Scholar
6Majithia, A, Tatla, T, Sandhu, G, Saleh, HA, Clarke, PM. Intracranial polyps in patients with Samter's triad. Am J Rhinol 2007;21:5963CrossRefGoogle ScholarPubMed
7Shen, K, Peterson, M, Mafee, M, Nguyen, QT. Aural polyps in Samter's triad: case report and literature review. Otol Neurotol 2012;33:774–8Google Scholar
8Pfaar, O, Klimek, L. Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements. Curr Opin Allergy Clin Immunol 2006;6:161–6Google Scholar