Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-23T03:52:12.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Salivary gland tumours as second neoplasms: two cases and literature review

Published online by Cambridge University Press:  19 November 2009

N Zidar ,
N Gale ,
A Župevc  and
M Žargi
N Zidar*
Affiliation:
Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
N Gale
Affiliation:
Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
A Župevc
Affiliation:
Department of Otorhinolaryngology and Cervicofacial Surgery, Clinical Center, Ljubljana, Slovenia
M Žargi
Affiliation:
Department of Otorhinolaryngology and Cervicofacial Surgery, Clinical Center, Ljubljana, Slovenia
*
Address for correspondence: Dr Nina Zidar, Institute of Pathology, Medical Faculty, Korytkova 2, 1000 Ljubljana, Slovenia. Fax: +386 1 543 71 01 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

Patients who survive malignant tumours have an increased risk of second neoplasms, including those of the salivary glands. Mucoepidermoid carcinoma of the parotid gland is by far the most common type of second salivary gland tumour; other types have rarely been reported. We describe here two patients with a second tumour of the salivary glands.

Case reports:

The first patient was a 22-year-old woman with a low grade mucoepidermoid carcinoma of the parotid gland, which developed 21 years after completion of chemoradiotherapy for acute lymphoblastic leukaemia. The second patient was a 40-year-old woman with an epithelial-myoepithelial carcinoma of the buccal mucosa, which arose 11 years after treatment for two malignant neoplasms – retroperitoneal liposarcoma and squamous cell carcinoma of the uterine cervix.

Conclusions:

It is mandatory that survivors of cancer should be monitored carefully, so that the complications related to their previous disease and therapy are detected early and managed properly.

Keywords

Salivary Gland NeoplasmsMucoepidermoid CarcinomaTumour Metastasis
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 5 , May 2010 , pp. 577 - 580
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Eveson, JW, Auclair, P, Gnepp, DR, El-Naggar, AK. Tumours of the salivary glands. In: Barnes, L, Eveson, JW, Reichart, PA, Sidransky, D, eds. WHO classification of tumours, Pathology and genetics of head and neck tumours. Lyon: IARC, 2005;212–15Google Scholar
2Luna, MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol 2006;13:293–307CrossRefGoogle ScholarPubMed
3Dickerman, JD. The late effects of childhood cancer therapy. Pediatrics 2007;119:554–68CrossRefGoogle ScholarPubMed
4Kony, SJ, de Vathaire, F, Chompret, A, Shamsaldim, A, Grimaud, E, Raquin, MA et al. Radiation and genetic factors in the risk of second malignant neoplasms after a first cancer in childhood. Lancet 1997;350:91–5CrossRefGoogle ScholarPubMed
5Bassal, M, Mertens, AC, Taylor, L, Neglia, JP, Greffe, BS, Hammond, S et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 2006;24:476–83CrossRefGoogle ScholarPubMed
6Guérin, S, Guibout, C, Shamsaldin, A, Dondon, MG, Diallo, I, Hawkins, M et al. Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study. Int J Cancer 2006;120:96–102CrossRefGoogle Scholar
7Jazbec, J, Todorovski, L, Jereb, B. Classification tree analysis of second neoplasms in survivors of childhood cancer. BMC Cancer 2007;7:27CrossRefGoogle ScholarPubMed
8Munker, R, Grützner, S, Hiller, E, Aydemir, Ü, Enne, W, Dietzfelbinger, H et al. Second malignancies after Hodgkin's disease: the Munich experience. Ann Hematol 1999;78:544–54CrossRefGoogle ScholarPubMed
9Schneider, AB, Lubin, J, Ron, E, Abrahams, C, Stovall, M, Goel, A et al. Salivary gland tumors after childhood radiation treatment for benign conditions of the head and neck: dose-response relationships. Radiat Res 1998;149:625–30CrossRefGoogle ScholarPubMed
10Belsky, JL, Takeichi, N, Yamamoto, T, Cihak, RW, Hirose, F, Ezaki, H et al. Salivary gland neoplasms following atomic radiation: additional cases and reanalysis of combined data in a fixed population, 1957-1970. Cancer 1975;35:555–93.0.CO;2-G>CrossRefGoogle Scholar
11Takeichi, N, Hirose, F, Yamamoto, H, Ezaki, H, Fujikura, T. Salivary gland tumors in atomic bomb survivors, Hiroshima, Japan. II. Pathologic study and supplementary epidemiologic observations. Cancer 1983;52:377–853.0.CO;2-9>CrossRefGoogle ScholarPubMed
12Kaste, SC, Hedlund, G, Pratt, CB. Malignant parotid tumors in patients previously treated for childhood cancer: clinical and imaging findings in eight cases. Am J Roentgenol 1994;162:655–9CrossRefGoogle ScholarPubMed
13Rutigliano, DN, Meyers, P, Ghossein, RA, Carlson, DL, Kayton, ML, Kraus, D et al. Mucoepidermoid carcinoma as a secondary malignancy in pediatric sarcoma. J Pediatr Surg 2007;42:E9–13CrossRefGoogle ScholarPubMed
14Loy, TS, McLaughlin, R, Odom, LF, Dehner, LP. Mucoepidermoid carcinoma of the parotid as a second malignant neoplasm in children. Cancer 1989;64:2174–73.0.CO;2-F>CrossRefGoogle ScholarPubMed
15Zappia, JJ, McClatchey, KD. Mucoepidermoid carcinoma associated with acute lymphoblastic leukemia. Int J Pediatr Otorhinolaryngol 1992;23:85–9CrossRefGoogle ScholarPubMed
16Ceha, HM, Balm, AJ, de Jong, D, van't Veer, LJ. Multiple malignancies in a patient with bilateral retinoblastoma. J Laryngol Otol 1998;112:189–92Google Scholar
17Prasannan, L, Pu, A, Hoff, P, Weatherly, R, Castle, V. Parotid carcinoma as a second malignancy after treatment of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 1999;21:535–8CrossRefGoogle ScholarPubMed
18Socié, G, Curtis, RE, Deeg, HJ, Sobocinski, KA, Filipovich, AH, Travis, LB et al. New malignant diseases after allogenic marrow transplantation for childhood acute leukemia. J Clin Oncol 2000;18:348–57CrossRefGoogle ScholarPubMed
19Sandoval, C, Jayabose, S. Parotid mucoepidermoid carcinoma following chemotherapy for childhood lymphoblastic leukemia. Pediatr Hematol Oncol 2001;18:217–20CrossRefGoogle Scholar
20Bhatia, S, Sather, HN, Pabustan, OB, Trigg, ME, Gaynon, PS, Robison, LL. Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 2002;99:4257–64CrossRefGoogle ScholarPubMed
21Manzitti, C, Mereu, P, Haupt, R, Di Blasi, A, Bellani, FF, Dallorso, S. Parotid carcinoma after autologous bone marrow transplantation for relapsed nephroblastoma. J Pediatr Hematol Oncol 2003;25:672–3CrossRefGoogle ScholarPubMed
22Vázques, E, Castellote, A, Piqueras, J, Ortuňo, P, Sánchez-Toledo, J, Nogués, P et al. Second malignancies in pediatric patients: imaging findings and differential diagnosis. Radiographics 2003;23:1155–72CrossRefGoogle Scholar
23Boccon-Gibod, L, Boman, F, Josset, P, Landman-Parker, J. Mucoepidermoid carcinoma of the parotid gland in a child previously treated for acute lymphoblastic leukemia. Pediatr Blood Cancer 2005;44:673–5CrossRefGoogle Scholar
24Paulino, AC, Fowler, BZ. Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol 2005;22:89–101CrossRefGoogle ScholarPubMed
25Savelli, SL, Klopfenstein, KJ, Termuhlen, AM. Mucoepidermoid carcinoma of the parotid gland as a second malignant neoplasm. Pediatr Blood Cancer 2005;45:997–1000CrossRefGoogle ScholarPubMed
26Beal, MP, Singh, B, Kraus, D, Yahalom, J, Portlock, C, Wolden, SL. Radiation-induced salivary gland tumors: a report of 18 cases and a review of the literature. Cancer J 2003;9:467–71CrossRefGoogle Scholar
27Piccinelli, KJ, Taj, M, Lucraft, HH, Skinner, R. Secondary parotid mucoepidermoid carcinoma after TBI and chemotherapy in childhood AML. Pediatr Blood Cancer 2006;47:345–6CrossRefGoogle ScholarPubMed
28Védrine, PO, Coffinet, L, Temam, S, Montagne, K, Lepeyre, M, Oberlin, O et al. Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 secondary malignant neoplasms. Head Neck 2006;28:827–33CrossRefGoogle Scholar
29Whatley, WS, Thompson, JW, Rao, B. Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg 2006;134:385–8CrossRefGoogle ScholarPubMed
30Hijiya, N, Hudson, MM, Lensing, S, Zacher, M, Onciu, M, Behm, FG et al. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 2007;297:1207–15CrossRefGoogle ScholarPubMed
31Cheuk, DK, Shek, TW, Chan, GC, Lau, YL, Ha, SY, Chiang, AK. Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008;50:636–9CrossRefGoogle Scholar