Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-26T16:59:48.675Z Has data issue: false hasContentIssue false
  • English
  • Français

Safe application of mitomycin C within the nasal cavity

Published online by Cambridge University Press:  07 January 2011

T Gutierrez  and
C Hopkins
T Gutierrez*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK
C Hopkins
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK
*
Address for correspondence: Ms Tatiana Gutierrez, Guy's and St Thomas’ NHS Trust, Great Maze Pond, London SE1 9RT, UK E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To describe a novel technique of delivering mitomycin C safely via endoscopic sinus surgery.

Case report:

Mitomycin C was applied in the median frontal drainage pathway of a 44-year-old woman suffering from recalcitrant chronic frontal sinusitis. The mitomycin C was soaked onto a neurosurgical patty, which was delivered through a nasopharyngeal tube trimmed to ensure delivery directly to the desired area, thus sparing adjacent mucosa.

Conclusions:

Mitomycin C has been suggested to have a useful role in reducing post-operative scarring after endonasal surgery. The long term safety of topical mitomycin C is not yet known, and inadvertent topical application to adjacent mucosa should be avoided. The described technique achieves this in a simple manner, and can be easily applied to other locations.

Keywords

Frontal SinusMitomycin CEndoscopic SurgeryComplications
Type
Short Communications
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 3 , March 2011 , pp. 309 - 310
Copyright
Copyright © JLO (1984) Limited 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Tabaee, A, Brown, SM, Anand, VK. Mitomycin C and endoscopic sinus surgery: where are we? Curr Opin Otolaryngol Head Neck Surg 2007;15:40–3CrossRefGoogle ScholarPubMed
2Amonoo-Kuofi, K, Lund, V, Andrews, P, Howard, D. The role of mitomycin C in surgery of the frontonasal recess: a prospective open pilot study. Am J Rhinol 2006;20:591–4CrossRefGoogle Scholar
3Heran, M, Baird, R, Blair, G, Skarsgard, E. Topical mitomycin C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. J Pediatr Surg 2008;43:815–18CrossRefGoogle ScholarPubMed