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Role of prophylactic antibiotics in surgery for advanced head and neck cancer

Published online by Cambridge University Press:  29 June 2007

D. A. Tandon ,
S. Bahadur ,
H. C. Laldina  and
K. R. Sundaram
D. A. Tandon*
Affiliation:
New Delhi, India
S. Bahadur
Affiliation:
New Delhi, India
H. C. Laldina
Affiliation:
New Delhi, India
K. R. Sundaram
Affiliation:
New Delhi, India
*
D. A. Tandon, Department of Otolaryngology, All Indian Institute of Medical Sciences, New Delhi 110029, India.
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Abstract

Four regimens of prophylactic antibiotics were utilized in 122 consecutive patients of stages III and IV carcinoma of the upper aero-digestive tract undergoing major resections in a randomized single-blind study. Ampicillin, gentamicin, cephalexin and metronidazole were used in different combinations for periods of 5 or 10 days. A cephalexin-metronidazole protocol for 10 days was associated with lowest post-operative infection rate. Oral-oropharyngeal resection and use of pectoralis major myocutaneous flap were the most important factors contributing to infection.

Keywords

AntibioticsHead and neck neoplasmsCephalexinmetronidazole
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 7 , July 1992 , pp. 621 - 624
Copyright
Copyright © JLO (1984) Limited 1992

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