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The rate and pattern of otic epithelial migration: systematic review

Published online by Cambridge University Press:  02 November 2021

J Saniasiaya Open the ORCID record for J Saniasiaya [Opens in a new window]  and
N Prepageran
J Saniasiaya*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
N Prepageran
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
*
Author for correspondence: Dr Jeyasakthy Saniasiaya, Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603Kuala Lumpur, Malaysia E-mail: [email protected] Fax: +60 75 564 333
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Abstract

Background

Epithelial migration has been associated with the self-cleansing mechanism of the ear. The rate and pattern of epithelial migration in healthy and pathological ears are reviewed.

Methods

Two authors independently screened articles over one month using the following search terms: epithelial migration, epithelial, tympanic membrane, external auditory canal and mastoidectomy cavity.

Results

Ten studies were included. The fastest rate of epithelial migration was observed in the external auditory canal, with a mean of 144.75 μm per day, whereas the slowest epithelial migration was seen in post-mastoidectomy cavities, with a rate of 20 μm per day. Epithelial migration was present in both studies involving post-mastoidectomy cavities.

Conclusion

Epithelial migration is faster in healthy tympanic membrane than in pathological tympanic membrane. The rate of epithelial migration in the external auditory canal was higher in the pathological group than in the healthy group. Epithelial migration is present in post-mastoidectomy cavities.

Keywords

EpidermisMigrationTympanic MembraneExternal Auditory CanalMastoid
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 10 , October 2022 , pp. 892 - 897
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr J Saniasiaya takes responsibility for the integrity of the content of the paper

References

Burnett, CH. The Ear: Its Anatomy, Physiology, and Diseases. Philadelphia: HC Lea's Son & Co, 1884Google Scholar
Buck, AH. Diagnosis and Treatment of Ear Diseases. New York: W Wood, 1880Google Scholar
Bezold, F, Siebenmann, F. Textbook of Otology. Chicago: E Colegrove Co, 1908Google Scholar
Stinson, WD. Reparative process in membrane tympani. Arch Otolaryngol 1936;24:600–5CrossRefGoogle Scholar
Alberti, PW. Epithelial migration of tympanic membrane. J Laryngol Otol 1964;78:808–30CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlff, J, Altman, DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. BMJ 2009;339:b2535Google ScholarPubMed
Higgins, JPT, Green, S, eds. Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. London: Cochrane Collaboration, 2011Google Scholar
National Heart, Lung, and Blood Institute. Quality Assessment Tool for Case Series Studies. In: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools [13 July 2022]Google Scholar
O'Donoghue, GM. Epithelial migration on the tympanic membrane of children. Int J Pediatr Otorhinolaryngol 1983;6:119–25Google ScholarPubMed
Makino, K, Amatsu, M. Epithelial migration on the tympanic membrane and external canal. Arch Otorhinolaryngol 1986;243:39–42Google ScholarPubMed
Michaels, L, Soucek, S. Auditory epithelial migration on the human tympanic membrane: II. The existence of two discrete migratory pathways and their embryologic correlates. Am J Anat 1990;189:189–200CrossRefGoogle ScholarPubMed
Moriarty, BG, Johnson, AP, Patel, P. Patterns of epithelial migration in the unaffected ear in patients with a history of unilateral cholesteatoma. Clin Otolaryngol 1991;16:48–51CrossRefGoogle ScholarPubMed
Bonding, P, Charabi, S. Epithelial migration in mastoid cavities. Clin Otolaryngol 1994;19:306–9CrossRefGoogle ScholarPubMed
Deong, KK, Narayanan, P, Raman, R. Epithelial migration of the postmyringoplasty tympanic membrane. Otol Neurotol 2006;27:855–8CrossRefGoogle ScholarPubMed
Ong, CA, Narayanan, P, Godbole, S, Raman, R. Epithelial migration in open mastoidectomy cavities. Asian J Surg 2007;30:57–9CrossRefGoogle ScholarPubMed
Tang, IP, Narayanan, P, Raman, R, Sharizhal, T. Epithelial migration in the atelectatic tympanic membrane. J Laryngol Otol 2009;123:1321–4CrossRefGoogle ScholarPubMed
Revadi, G, Prepageran, N, Raman, R, Sharizal, TA. Epithelial migration on the external ear canal in normal and pathologic ears. Otol Neurotol 2011;32:504–7CrossRefGoogle ScholarPubMed
Santhi, K, Prepageran, N, Tang, IP, Raman, R. Study of epithelial migration in the tympanic membrane and bony external auditory canal wall in patients with irradiated nasopharyngeal carcinoma. Otol Neurotol 2015;36:318–22CrossRefGoogle ScholarPubMed
Youngs, R, Hawke, M, Ekem, JK, Stratis, M. Corneocyte architecture in the human external auditory meatus. J Otolaryngol 1988;17:244–8Google Scholar
Youngs, R, Hawke, WM. Stratum corneum morphology in the human tympanic membrane and external auditory meatus. J Otolaryngol 1988;17:346–51Google ScholarPubMed
Magnoni, A. Observations on the migrations of the tympanic membrane epithelia [in Italian]. Valsalva 1938;14:234Google Scholar
Litton, WB. Epithelial migration over tympanic membrane and external canal. Arch Otolaryngol 1963;77:254–7Google ScholarPubMed
Link, R. About the vascular supply of the eardrum and the auditory canal [in German]. Arch Ohren Nasen Kehlkopfheilkd 1952;160:561–72CrossRefGoogle Scholar
Persaud, RAP, Hajioff, D, Thevasagayam, MS, Wareing, MJ, Wright, A. Keratosis obturans and external ear canal cholesteatoma: how and why we should distinguish between these conditions. Clin Otolaryngol 2004;29:577–81CrossRefGoogle ScholarPubMed