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Osteosclerotic Plasmacytoma of maxillary bone (orbital floor)

Published online by Cambridge University Press:  29 June 2007

Thomas A. Mustone ,
Marvin P. Fried ,
Max L. Goodman ,
James H. Kelly  and
Marshall Strome
Thomas A. Mustone
Affiliation:
Boston, U.S.A.
Marvin P. Fried*
Affiliation:
Boston, U.S.A.
Max L. Goodman
Affiliation:
Boston, U.S.A.
James H. Kelly
Affiliation:
Boston, U.S.A.
Marshall Strome
Affiliation:
Boston, U.S.A.
*
Dr. Marvin P. Fried M. D., Join Center for Otolaryngology, Beth Israel Hospital, Brigham and Women's Hospital, 398 Brookline Avenue. Boston, Massachusetts 02215. USA.
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Abstract

Plasma cell neoplasms have been classified as multiple myeloma, solitary plasmacytoma and extramedullary plasmacytoma. They are usually considered as osteolytic lesions of bone except for the rare occurrence of osteosclerotic lesions. This paper describes the first reported osteosclerotic plasmacytoma of the maxillary bone and orbital floor. The difficulties in establishing a diagnosis and the relationship to other plasma cell neoplasms are discussed.

Osteosclerotic plasmacytomas are a rare variant of plasma cell tumors which usually produce osteolytic lesions rather than bony sclerosis. Sixty-eight patients with the osteosclerotic variant have appeared in the world literature, with an overall incidence of about 1 per cent in a large series of plasma cell neoplasms (Dreidger and Pruzanski, 1979). There have been only six previous cases of solitary osteosclerotic plasmacytomas reported (Morley and Schweiger, 1964; Roberts et al., 1974; Rodriguez et al. 1976; Rushton, 1965; Schneinker, 1938; Brigham Medical Review, 1961) involving spine, sternum, or rib. None have previously been reported in the head and neck area.

Plasma cell tumors have been classified into multiple myeloma, solitary plasmacytomas of bone, and extramedullary plasmacytomas. Multiple myeloma is a disseminated plasma cell malignancy characterized by the production of homogeneous immunoglobulins (whole or fragments) which appear in the serum and urine. Plasma cell tumors can also occur as solitary plasmacytomas, usually in bone, but also in soft tissue. With time, most solitary plasmacytomas develop disseminated disease with all the characteristics of multiple myeloma (Wiltshaw, 1976). Extramedullary plasmacytomas arise in soft tissue rather than bone, and primarily occur in the head and neck region. Clinically, they remain localized and less frequently develop into disseminated myeloma.

Type
Clinical records
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 9 , September 1984 , pp. 929 - 938
Copyright
Copyright © JLO (1984) Limited 1984

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References

Brigham Medical Review (1961) Report on a clinicopathological conference. 20: 546–552.Google Scholar
Chavis, R. M., Garner, A. and Wright, J. E. (1978) Inflammatory orbital pseudotumor. A clinicopathological study. Archives of Ophthalmology, 96: 1817–1822.CrossRefGoogle Scholar
Corwin, J. and Lindberg, R. D. (1979) Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer, 43: 1001–1013.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Dolin, S. and Dwar, J. P. (1956) Extramedullary plasmacytoma. American Journal of Pathology, 32: 83–103.Google ScholarPubMed
Dreidger, H. and Pruzanski, N. (1979) Plasma cell neoplasia with osteosclerotic lesions—a study of five cases and a review of the literature. Archives of Internal Medicine, 139: 892–896.CrossRefGoogle Scholar
Dreidger, H. and Pruzanski, N. (1980) Plasma cell neoplasia with peripheral neuropathy—a study of five cases and a review of the literature. Medicine, 59: 301–310.CrossRefGoogle Scholar
Dresmy, P., Limon, S., Dufrus, J. L. et al. (1977) A typical orbital localization of a myeloma of extramedullary plasmacytoma. Arch Opthalmologica (Paris), 37: 3–20.Google Scholar
Fine, R. S., Amjad, H. and Schneid, J. R. (1978) Case report—plasmacytoma presenting in unilateral proptosis. Post Graduate Acute Medicine, 64: 178–179.Google ScholarPubMed
Fri Yoo-Shi, and Perizris, K. (1978) Nonepithelial tumors of the ńasal cavity, paranasal sinus and nasopharynx. A clinicopathologic study IX. Plassmacytomas. Cancer, 42: 2399–2406.Google Scholar
Jonasson, F. (1978) Orbital plasma cell tumors. Opthalmologica, 177: 152–157.CrossRefGoogle Scholar
Kuzel, R. B. and Mausolf, F. (1978) Orbital involvement of an extramedullary plasmacytomas. Opthalmologica, 176: 241–244.CrossRefGoogle Scholar
Langleu, C. R., Sabean, H. B. and Sorger, K. (1966) Sclerotic lesions of bone in myeloma. Canadian Medical Association Journal, 94: 940.Google Scholar
Levin, S. R., Spaulding, A. G. and Witman, J. A. (1977) Multiple myeloma, orbital involvement in a youth. Archives of Ophthalmology, 75: 642–644.CrossRefGoogle Scholar
Massachusetts General Hospital. (1972) Weekly Clinicopathological Exercises. New England Journal of Medicine, 138–144.Google Scholar
Mill, W. B. and Griffith, R. (1980) The role of radiation therapy in the management of plasma cell tumors. Cancer, 45: 647–652.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Morley, J. B. and Schweiger, A. C. (1964) The relation between chronic polyneuropathy and osteosclerotic myeloma. Journal of Neurology, Neurosurgery and Psychiatry, 300: 432–442.Google Scholar
Mottow, L. S. and Jokobie, F. A. (1976) Idiopathic inflammatory orbital pseudotumor in childhood—clinical characteristics. Archives of Ophthalmology, 96: 1410–1477.CrossRefGoogle Scholar
Roberts, M. R., Rinaudo, P. J., Vilinskas, J. and Owens, G. (1974) Solitary sclerosing plasma cell myeloma of the spine. Case Report. Journal of Neurosurgery, 409: 125–129.CrossRefGoogle Scholar
Rodman, H. I. and Font, R. L. (1972) Orbital involvement in multiple myeloma: a review of the literature and report of three cases. Archives of Ophthalmology, 87: 30–35.CrossRefGoogle ScholarPubMed
Rodriguez, A. R., Lutcher, C. L. and Coleman, F. O. (1976) Ostoclerotic myeloma. Journal of the American Medical Association, 236: 1872–1874.CrossRefGoogle ScholarPubMed
Rushton, D. I. (1965) Peripheral sensorimotor neuropathy associated with a localized myeloma. British Medical Journal, 2: 203.CrossRefGoogle ScholarPubMed
Schneinker, I. (1938) Myeloma und Nerven System. Deutsche Nervenheilkunde, 7: 254–273.Google Scholar
Wiltshaw, E. (1976) The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine, 55: 217–238.CrossRefGoogle ScholarPubMed