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Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit

Published online by Cambridge University Press:  14 December 2011

F M A Butt ,
M L Chindia  and
F Rana
F M A Butt*
Affiliation:
Department of Human Anatomy, University of Nairobi, Kenya
M L Chindia
Affiliation:
Department of Oral and Maxillofacial Surgery, University of Nairobi, Kenya
F Rana
Affiliation:
Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya
*
Address for correspondence: Dr F M A Butt, P O Box 25361, Code 00603, Nairobi, Kenya Fax: +254 20 2710712 E-mail: [email protected]
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Abstract

Background:

Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives.

Aim:

To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus.

Study design:

Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus.

Results:

Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18–43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification).

Conclusion:

Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.

Keywords

Oral CavityCarcinoma, Squamous CellEpidemiologyHuman Immunodeficiency Virus
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 3 , March 2012 , pp. 276 - 278
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Parkin, DM, Sitas, F, Chirenje, M, Stein, L, Abratt, R, Wabinga, H. Part I: Cancer in indigenous Africans – burden, distribution, and trend. Lancet Oncol 2008;9:683–92CrossRefGoogle Scholar
2Ledergerber, B, Egger, M, Telenti, A. AIDS-related opportunistic illness and potent antiretroviral therapy. JAMA 2000;283:2653–4Google ScholarPubMed
3Hessol, NA, Pipkin, S, Schwarcz, S, Cress, RD, Bacchetti, P, Scheer, S. The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS. Am J Epidemiol 2007;165:1143–53CrossRefGoogle ScholarPubMed
4Frisch, M, Biggar, RJ, Engels, EA, Goedert, JJ. Association of cancer with AIDS-related immunosuppression in adults. JAMA 2001;285:1736–45CrossRefGoogle ScholarPubMed
5Haigentz, M Jr.Aerodigestive cancers in HIV infection. Curr Opin Oncol 2005;17:474–8CrossRefGoogle ScholarPubMed
6Singh, B, Balwally, AN, Shaha, AR, Rosenfeld, RM, Har-El, G, Lucente, FE. Upper aerodigestive tract squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 1996;122:639–43CrossRefGoogle ScholarPubMed
7Roland, JT Jr, Rothstein, SG, Mittal, KR. Squamous cell carcinoma in HIV-positive patients under the age of 45. Laryngoscope 1993;103:509–11CrossRefGoogle Scholar
8Grulich, AE, Wan, X, Law, MG, Coates, M, Kaldor, JM. Risk of cancer in people with AIDS. AIDS 1999;13:839–43CrossRefGoogle ScholarPubMed
9Serraino, D, Boschini, A, Carrieri, P, Pradier, C, Dorruci, M, Maso, LD et al. Cancer risk among men with, or at risk of, HIV infection in southern Europe. AIDS 2000;14:553–9CrossRefGoogle ScholarPubMed
10Phelps, RM, Smith, DK, Heilig, CM, Gardner, LI, Carpenter, CC, Klein, RS et al. Cancer incidence in women with or at risk of HIV. Int J Cancer 2001;94:753–7CrossRefGoogle ScholarPubMed
11Grulich, A, Li, Y, McDonald, A, Correll, P, Law, M, Kaldor, J. Rates of non-AIDS defining cancers in people with HIV infection before and after AIDS diagnosis. AIDS 2002;16:1155–61CrossRefGoogle ScholarPubMed
12Shiboski, CH, Shiboski, SC, Silverman, SJ. Trends in oral cancer rates in the United States, 1973–1976. Community Dent Oral Epidemiol 2000;28:249–50CrossRefGoogle Scholar
13Singh, B, Sabin, S, Rofim, O, Shaha, A, Har-El, G, Lucente, FE. Alterations in head and neck cancer occurring in HIV-infected patients. Acta Oncol 1999;38:1047–50CrossRefGoogle ScholarPubMed