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Oncogenic osteomalacia: case report and review of head and neck associated tumours

Published online by Cambridge University Press:  29 June 2007

X. Gonzalez-Compta ,
M. Mañós-Pujol ,
M. Foglia-Fernandez ,
E. Peral ,
E. Condom ,
T. Claveguera  and
M. Dicenta-Sousa
X. Gonzalez-Compta*
Affiliation:
Department of Oto-rhino-laryngology, Ciutat Sanitària Universitària de Bellvitge, Barcelona, Spain.
M. Mañós-Pujol
Affiliation:
Department of Oto-rhino-laryngology, Ciutat Sanitària Universitària de Bellvitge, Barcelona, Spain.
M. Foglia-Fernandez
Affiliation:
Department of Oto-rhino-laryngology, Ciutat Sanitària Universitària de Bellvitge, Barcelona, Spain.
E. Peral
Affiliation:
Department of Neurology, Ciutal Sanitària Universitària de Bellvitge, Barcelona, Spain.
E. Condom
Affiliation:
Department of Pathology, Ciutal Sanitària Universitària de Bellvitge, Barcelona, Spain.
T. Claveguera
Affiliation:
Department of Rheurmatology, Ciutal Sanitària Universitària de Bellvitge, Barcelona, Spain.
M. Dicenta-Sousa
Affiliation:
Department of Oto-rhino-laryngology, Ciutat Sanitària Universitària de Bellvitge, Barcelona, Spain.
*
Address for correspondence: Xavier Gonzalez-Compta, C/Montserrat de Casanovas, 124, 2°4a Barcelona - 08032, Spain. Fax: (3) 207 50 63
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Abstract

Oncogenic osteomalacia is an uncommon syndrome characterized by mineral metabolism abnormalities that disappear after the resection of an associated tumour. Head and neck is the second most frequent location of these tumours. We describe a case with an ethmoido-frontal phosphaturic mesenchymal tumour and review oncogenic osteomalacia-associated tumours. Among 21 cases found, 57 per cent affected the sinonasal area and 20 per cent the mandible. The diagnosis of the tumour lasted a mean of 4.7 years from the onset of osteomalacia, and most of them showed a significant vascular component. An aggressive surgical approach is recommended.

Keywords

Head and neck neoplasmsOsteomalaciaHypophosphataemia
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 4 , April 1998 , pp. 389 - 392
Copyright
Copyright © JLO (1984) Limited 1998

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References

Cai, Q., Hodgson, S. F., Kao, P. C., Lennon, V. A., Klee, G. G., Zinsmiester, A. R., Kumar, R. (1994) Inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. New England Journal of Medicine 330: 1645–1649.CrossRefGoogle Scholar
Camus, J. P., Crouzet, J., Prier, A., Guillemant, S., Ulmann, A., Koeger, A. C. (1980) Ostéomalacies hypophosphorémiques guéries par l'ablation de tumeurs benignes du tissu conjonctif. Étude de trois observations avec dosages pré-et post-opératoires des métabolites de la vitamine D. Annals de Médecine Interne (Paris) 131: 422–426.Google Scholar
Catalano, P. J., Brandwein, M., Shah, D. K., Urken, M. L., Lawson, W., Biller, H. F. (1996) Sinonasal hemangiopericytomas: a clinicopathologic and immunohistochemical study of seven cases. Head and Neck 18: 42–53.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Chacko, V., Joseph, B. (1981) Osteomalacia associated with haemangiopericytoma. Journal of the Indian Medical Association 76: 173–175.Google ScholarPubMed
Compagno, J. (1978) Hemangiopericytoma-like tumors of the nasal cavity: a comparison with hemangiopericytoma of soft tissues. Laryngoscope 88: 460–469.CrossRefGoogle ScholarPubMed
Crouzet, J., Mimoune, H., Beraneck, L., Juan, L. H. (1995) Hypophosphatemia osteomalacia with plantar neurilenoma. A review of the literature (100 cases). Revue du Rhumatisme (Engl. Ed.) 62: 463–466.Google Scholar
Econs, M. J., Drezner, M. K. (1994) Tumor-induced osteomalacia: Unveiling a new hormone. New England Journal of Medicine 330: 1679–1681.CrossRefGoogle ScholarPubMed
Evans, D. J., Azzopardi, J. G. (1972) Distinctive tumours of bone and soft tissue causing acquired vitamin-D-resistant osteomalacia. Lancet 1: 353–354.Google ScholarPubMed
Hioco, J., Chanzy, M. O., Hioco, F., Voisin, M. C., Villiaumey, J. (1981) Osteomalacia with mesenchymatous tumors - two new cases. XVe Congres International de Rhumatologie, Paris, 1981. Revue du Rhumatisme et Maladies Osteoarticulaires 48 - N° Special: 890.Google Scholar
Jefferis, A. F., Taylor, P. C. A., Walsh-Waring, G. P. (1985) Tumour-associated hypophosphataemic osteomalacia occurring in a patient with an odontogenic tumour of the maxilla. Journal of Laryngology and Otology 99: 1011–1017.CrossRefGoogle Scholar
Kim, Y. G., Coi, Y. S., Lee, S. C., Ryu, D. M. (1996) Tumorinduced osteomalacia associated with lesions in the oral and maxillofacial region: report of two cases. Journal of Oral and Maxillofacial Surgery 54: 1352–1357.CrossRefGoogle ScholarPubMed
Lee, H. K., Sung, W. W., Solodnik, P., Shimshi, M. (1995) Bone scan in tumor-induced osteomalacia. Journal of Nuclear Medicine 36: 247–249.Google ScholarPubMed
Linsey, M., Smith, W., Yamauchi, H., Bernstein, L. (1983) Nasopharyngeal angiofibroma presenting as adult osteomalacia: case report and review of the literature. Laryngoscope 93: 1328–1331.CrossRefGoogle ScholarPubMed
McCance, R. A. (1947) Osteomalacia with Looser's nodes (Milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Quarterly Journal of Medicine 16: 33–47.Google ScholarPubMed
Miyauchi, A., Fukase, M., Tsutsumi, M., Fujita, T. (1988) Hemangiopericytoma-induced osteomalacia: Tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity. Journal of Clinical Endocrinology and Metabolism 67: 46–53.CrossRefGoogle ScholarPubMed
Nitzan, D. W., Marmary, Y., Azaz, B. (1981) Mandibular tumor-induced muscular weakness and osteomalacia. Oral Surgery 52: 253–256.CrossRefGoogle ScholarPubMed
Nomura, G., Koshino, Y., Morimoto, H., Kida, H., Nomura, S., Tamai, K. (1982) Vitamin D resistant hypophosphatemic osteomalacia associated with osteosarcoma of the mandible: report of a case. Japanese Journal of Medicine 21: 35–39CrossRefGoogle ScholarPubMed
Nortman, D. F., Brautbar, N., Coburn, J. W., Sherrard, D. J., Haussler, M. R., Dinger, F. R., Brickman, A.S., Barton, R. T. (1981) Response of tumor-associated osteomalacia to 1,25(OH)2-vitamin D3. Clinical Research 27: 92A.Google Scholar
Nuovo, M. A., Dorfman, H. D., Sun, C. J., Chalew, S. A. (1989) Tumor-induced osteomalacia and rickets. American Journal of Surgical Pathology 13: 588–599.CrossRefGoogle ScholarPubMed
Olefsky, J., Kempson, R., Jones, H., Reaven, G. (1972) ‘Tertiary’ hyperparathyroidism and apparent ‘cure’ of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. New England Journal of Medicine 286: 740–745.CrossRefGoogle ScholarPubMed
Prader, A., Illig, R., Uehlinger, R. E., Stalder, G. (1959) Rachitis infolge knochentumors (Rickets caused by bone tumors). Helvetica Paediatria Acta 14: 554–565.Google Scholar
Renton, P., Shaw, D. G. (1976) Hypophosphatemic osteomalacia secondary to vascular tumors of bone and soft tissue. Skeletal Radiology 1: 21–24.CrossRefGoogle Scholar
Ryan, E. A., Reiss, E. (1984) Oncogenous osteomalacia. Review of the world literature of 42 cases and report of two new cases. American Journal of Medicine 77: 501–512.CrossRefGoogle ScholarPubMed
Seshadri, M. S., Cornish, C. J., Mason, R. S., Posen, S. (1985) Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia. Clinical Endocrinology 23: 689–697.CrossRefGoogle ScholarPubMed
Sparagana, M. (1987) Tumor-induced osteomalacia: long-term follow-up of two patients cured by removal of their tumors. Journal of Surgical Oncology 36: 198–205.CrossRefGoogle ScholarPubMed
Sweet, R. A., Males, L. J., Hamstra, A. J., DeLuca, H. F. (1980) Vitamin D metabolite levels in oncogenic osteomalacia. Annals of Internal Medicine 93: 279–280.CrossRefGoogle ScholarPubMed
Weidner, N., Bar, R. S., Weiss, D., Strottmann, M. P. (1985) Neoplastic pathology of oncogenic osteomalacia/rickets. Cancer 55: 1691–1705.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Weidner, N. (1991) Review and update: oncogenic osteomalacia-rickets. Ultrastructural Pathology 15: 317–333.CrossRefGoogle ScholarPubMed
Wilkins, G. E., Granleese, S., Hegele, R. G., Holden, J., Anderson, D. W., Bondy, G. P. (1995) Oncogenic osteomalacia: evidence for a humoral phosphaturic factor. Journal of Clinical Endocrinology and Metabolism 80: 1628–1634.Google ScholarPubMed