Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-26T05:04:32.086Z Has data issue: false hasContentIssue false
  • English
  • Français

Not just another paediatric neck lump: metastatic cribriform adenocarcinoma of the palate in an adolescent

Published online by Cambridge University Press:  19 February 2015

A S Takhar ,
A Simmons ,
L Ffolkes  and
N Hyde
A S Takhar*
Affiliation:
Department of ENT Surgery, St George's Hospital, London, UK
A Simmons
Affiliation:
Department of ENT Surgery, St George's Hospital, London, UK
L Ffolkes
Affiliation:
Department of Cellular Pathology, St George's Hospital, London, UK
N Hyde
Affiliation:
Department of Oral and Maxillofacial Surgery (Thomas Tatum Head and Neck Unit), St George's Hospital, London, UK
*
Address for correspondence: Mr A S Takhar, 46 Plato Road, Brixton, London SW2 5UR, UK E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

This paper reports the case of a 13-year-old girl with a 2-year history of left cervical lymph node swelling that was diagnosed as metastatic cribriform adenocarcinoma of the tongue and minor salivary gland.

Case report:

A 13-year-old girl with a left, level II cervical lymph node underwent excisional biopsy after an ultrasound suggested suspicious features. The histology indicated polymorphous low-grade adenocarcinoma, and a primary lesion in the left palate was identified. The patient underwent left maxillectomy, neck dissection and reconstruction. Histological analysis of resection specimens led to a revised diagnosis of cribriform adenocarcinoma of the tongue and minor salivary gland.

Conclusion:

Cribriform adenocarcinoma of the tongue and minor salivary gland has recently been described as a separate entity to polymorphous low-grade adenocarcinoma in light of histological and behavioural differences, including higher rates of metastasis at presentation. This is the first report in the world literature of an adolescent with this entity. It is possible that some previous reports of polymorphous low-grade adenocarcinoma in childhood would have been more accurately described as cribriform adenocarcinoma of the tongue and minor salivary gland.

Keywords

Salivary GlandsPalateCarcinoma, CribriformAdenocarcinomaAdolescentHead And Neck Cancer
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 2 , February 2015 , pp. 194 - 197
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Evans, H, Batsakis, J. Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 14 cases of a distinctive neoplasm. Cancer 1984;53:935–42Google Scholar
2Luna, M, Wenig, B. Polymorphous low-grade adenocarcinoma. In: Barnes, L, Eveson, J, Reichart, P, Sidransky, D, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press, 2005;223–4Google Scholar
3Evans, HLMD, Luna, MAMD. Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol 2000;24:1319–28Google Scholar
4Castle, JT, Thompson, LDR, Frommelt, RA, Wenig, BM, Kessler, HP. Polymorphous low grade adenocarcinoma. Cancer 1999;86:207–19Google Scholar
5Tsang, YW, Tung, Y, Chan, JKC. Polymorphous low grade adenocarcinoma of the palate in a child. J Laryngol Otol 1991;105:309–11Google Scholar
6Kumar, M, Stivaros, N, Barrett, A, Thomas, G, Bounds, G, Newman, L. Polymorphous low-grade adenocarcinoma—a rare and aggressive entity in adolescence. Br J Oral Maxillofac Surg 2004;42:195–9Google Scholar
7Arora, S, Sreedharanunni, S, Dey, P. Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis. Diagn Cytopathol 2013;41:186–8Google Scholar
8Skalova, A, Sima, R, Kaspirkova-Nemcova, J, Simpson, R, Elmberger, G, Leivo, I et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol 2011;35:1168–76Google Scholar
9Michal, M, Kacerovska, D, Kazakov, D. Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. Head Neck Pathol 2013;7:3–11Google Scholar
10Prasad, K, Kaniyur, V, Pai, R, Nesari, S. Pedunculated cribriform adenocarcinoma of the base of tongue. Ear Nose Throat J 2004;83:62–4Google Scholar
11Borowsky-Borowy, P, Dyduch, G, Papla, B, Gabrys, I, Skladzien, J, Okon, K. Cribriform adenocarcinoma of the tongue. Pol J Pathol 2011;3:168–71Google Scholar
12Cocek, A, Hronkova, K, Voldanova, J, Sach, J, Skalova, A, Ambrus, M et al. Cribriform adenocarcinoma of the base of the tongue and low-grade, polymorphic adenocarcinomas of the salivary glands. Oncol Lett 2011;2:135–8Google Scholar
13Laco, J, Kamaradova, K, Vitkova, P, Sehnalkova, E, Dvorakova, S, Vaclavokova, E et al. Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HMBE-1 and contains polymorphisms of RET and H-RAS proto-oncogenes. Virchows Arch 2012;461:531–40Google Scholar
14Hannen, EJ, Bulton, J, Feston, JW, Wienk, SM, de Wilde, PCM. Polymorphous low-grade adenocarcinoma with distant metastasis and deletions on chromosome 6q23-qter and 11q23-qter: a case report. J Clin Pathol 2000;53:942–5Google Scholar
15Perez-Ordoñez, B, Linkov, I, Huvos, A. Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation. Histopathology 1998;32:521–9Google Scholar
16Slootweg, P, Muller, H. Low grade adenocarcinoma of the oral cavity: a comparison between the terminal duct and the papillary type. J Craniomaxillofac Surg 1987;15:359–64Google Scholar
17Vincent, S, Hammond, H, Finkelstein, M. Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Oral Endod 1994;77:41–7Google Scholar