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Non-insulin-dependent diabetic microangiopathy in the inner ear

Published online by Cambridge University Press:  29 June 2007

Chapman T. McQueen ,
Andrew Baxter ,
Timothy L. Smith ,
Eileen Raynor ,
Sang Min Yoon ,
Jiri Prazma  and
Harold C. Pillsbury III
Chapman T. McQueen*
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Andrew Baxter
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Timothy L. Smith
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Eileen Raynor
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Sang Min Yoon
Affiliation:
Department of Otolaryngology, Catholic University Medical College, St. Vincent Hospital, Suwon, Korea.
Jiri Prazma
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Harold C. Pillsbury III
Affiliation:
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina
*
Address for correspondence: Chapman T. McQueen, M.D., Division of Otolaryngology/Head & Neck Surgery, 610 Burnett-Womack Bldg., CB# 7070, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7070, USA. Fax: +919-966-7656
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Abstract

Hearing loss has long been associated with diabetes mellitus. Microangiopathy, associated with thickening of the basement membranes of small vessels, has been implicated as a major source of multiple system organ disease.

Objective This study was designed to evaluate changes in basement membrane thickness in the inner ear of laboratory animals suffering from non-insulin-dependent diabetes mellitus (NIDDM) with, and without, exposure to moderate intensity noise exposure in an attempt to extrapolate the same disease process in humans.

Design Spontaneously hypertensive-corpulent non-insulin-dependent rats (SHR/N-cp) were selected as a genetic model for the above study. Both lean and obese rats were used in this study. A genetically similar control group of animals (LA/N-cp) were used as controls. These animals express both the lean and obese phenotypes, but they lack the NIDDM gene. Forty-eight animals in each group were sacrificed at the end of the study. The cochleas were dissected and fixed. The basement membrane of the stria vascularis was examined using transmission electron microscopy.

Setting This study was a laboratory-based, standard animal study.

Main outcome This study was designed to show microangiography of the inner ear as related to NIDDM with, and without, obesity and noise exposure.

Results/Conclusions NIDDM alone does not cause statistically significant basement membrane thickening; however, NIDDM in combination with obesity and/or noise exposure did show significant thickening and the combination of all three showed the greatest thickening. NIDDM appeared to be the greatest contributing factor.

Keywords

Diabetes mellitusnon-insulin-dependentCochleaDiabetic angiopathierRats
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 1 , January 1999 , pp. 13 - 18
Copyright
Copyright © JLO (1984) Limited 1999

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