Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-25T01:01:20.820Z Has data issue: false hasContentIssue false
  • English
  • Français

New inflammatory parameters in laryngopharyngeal reflux

Published online by Cambridge University Press:  08 August 2016

H Arslan ,
T Çandar ,
S Kuran ,
Ş H Akmansu  and
S Kocatürk
H Arslan*
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
T Çandar
Affiliation:
Department of Biochemistry, Ufuk University Medical School, Ankara, Turkey
S Kuran
Affiliation:
Department of Gastroenterology, Çukurova University Medical School, Adana, Turkey
Ş H Akmansu
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
S Kocatürk
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
*
Address for correspondence: Dr Hande Arslan, Department of Otorhinolaryngology, Ufuk University Medical School, Balgat 06520, Ankara, Turkey E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment.

Methods:

Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment.

Results:

The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37.4 ± 11.6 years) and 35 healthy age- and sex-matched controls (7 men (20 per cent); mean age, 38.6 ± 8.9 years). The study group had significantly higher platelet-to-lymphocyte ratios and lower mean platelet volumes than the control group (p = 0.004 and p = 0.047, respectively). There was a significant correlation between platelet-to-lymphocyte ratios and initial inflammatory symptoms (reflux symptom index, p = 0.025; reflux finding score, p = 0.013). There was also a significant correlation between mean platelet volume increase and symptom resolution in the first and third months of treatment (p = 0.04 and p = 0.03, respectively).

Conclusion:

Platelet-to-lymphocyte ratio, a new inflammatory marker of chronic inflammation, was significantly higher in laryngopharyngeal reflux patients. Moreover, these patients had significantly lower mean platelet volume values, which increased with post-treatment symptom improvement.

Keywords

Laryngopharyngeal RefluxNeutrophilLymphocytePlateletMean Platelet Volume
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 878 - 882
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Bhat, T, Teli, S, Rijal, J, Bhat, H, Raza, M, Khoueiry, G et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55–9CrossRefGoogle ScholarPubMed
2 Atan, D, İkincioğulları, A, Köseoğlu, S, Özcan, KM, Çetin, MA, Ensari, S et al. New predictive parameters of Bell's palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 2015;32:167–70CrossRefGoogle ScholarPubMed
3 Torun, S, Tunc, BD, Suvak, B, Yildiz, H, Tas, A, Sayilir, A et al. Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity. Clin Res Hepatol Gastroenterol 2012;36:491–7CrossRefGoogle ScholarPubMed
4 Turkmen, K, Erdur, FM, Ozcicek, F, Ozcicek, A, Akbas, EM, Ozbicer, A et al. Platelet to lymphocyte ratio better predicts inflammation than neutrophil to lymphocyte ratio in end-stage renal disease patients. Hemodial Int 2013;17:391–6CrossRefGoogle ScholarPubMed
5 Sandhaus, LM, Meyer, P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002;118:787–93CrossRefGoogle ScholarPubMed
6 Kapsoritakis, AN, Koukourakis, MI, Sfiridaki, A, Potamianos, SP, Kosmadaki, MG, Koutroubakis, IE et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776–81CrossRefGoogle ScholarPubMed
7 Milovanovic, M, Nilsson, E, Jaremo, P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta 2004;343:237–40CrossRefGoogle ScholarPubMed
8 Yazici, S, Yazici, M, Erer, B, Erer, B, Calik, Y, Ozhan, H et al. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 2010;21:122–5CrossRefGoogle ScholarPubMed
9 Belafsky, PC, Postma, GN, Koufman, JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274–7CrossRefGoogle ScholarPubMed
10 Belafsky, PC, Postma, GN, Koufman, JA. Validity and reliability of the reflux finding score (RFS). Laryngoscope 2001;111:1313–17CrossRefGoogle ScholarPubMed
11 Dobhan, R, Castell, DO. Normal and abnormal proximal esophageal acid exposure: results of ambulatory dual-probe pH monitoring. Am J Gastroenterol 1993;88:25–9Google ScholarPubMed
12 Johnston, N, Wells, C, Blumin, J, Toohill, R, Merati, A. Receptor-mediated uptake of pepsin by laryngeal epithelial cells. Ann Otol Rhinol Laryngol 2007;116:934–8CrossRefGoogle ScholarPubMed
13 Carroll, T, Fedore, L, Aldahlawi, M. pH Impedance and high-resolution manometry in laryngopharyngeal reflux disease high-dose proton pump inhibitor failures. Laryngoscope 2012;122:2473–81CrossRefGoogle ScholarPubMed
14 Chiba, T, Kudara, N, Abiko, Y, Endo, M, Suzuki, K, Sugai, T et al. Effects of proton pump inhibitors in patients with laryngopharyngeal reflux disease. Hepatogastroenterology 2011;58:1580–2CrossRefGoogle ScholarPubMed
15 Balta, S, Demirkol, S, Unlu, M, Arslan, Z, Celik, T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer 2013;109:3125–6CrossRefGoogle ScholarPubMed
16 Motomura, T, Shirabe, K, Mano, Y, Muto, J, Toshima, T, Umemoto, Y et al. Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol 2013;58:58–64 CrossRefGoogle ScholarPubMed
17 Demir, M. The relationship between neutrophil lymphocyte ratio and non-dipper hypertension. Clin Exp Hypertens 2013;35:570–3CrossRefGoogle ScholarPubMed
18 Balta, S, Cakar, M, Demirkol, S, Arslan, Z, Akhan, M. Higher neutrophil to lymphocyte ratio in patients with metabolic syndrome. Clin Appl Thromb Hemost 2013;19:579 CrossRefGoogle ScholarPubMed
19 Jenne, CN, Kubes, P. Platelets in inflammation and infection. Platelets 2015;26:286–92CrossRefGoogle ScholarPubMed
20 Koufman, JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101(4 Pt 2 suppl 53):1–78 CrossRefGoogle Scholar
21 Ateş, F, Yaraş, S, Sarıtaş, B, Altıntaş, E, Sezgin, O, Orekici, G. Does neutrophil to lymphocyte ratio in peripheral blood predict endoscopic erosive esophagitis? Endoscopy 2011;19:88–90 Google Scholar
22 Briggs, C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277–97CrossRefGoogle ScholarPubMed
23 Kisacik, B, Tufan, A, Kalyoncu, U, Karadag, O, Akdogan, A, Ozturk, MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291–4CrossRefGoogle ScholarPubMed