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Nasal manifestation of extranodal Rosai-Dorfman disease – diagnosis and management

Published online by Cambridge University Press:  29 June 2007

Peter K. M. Ku ,
Michael C. F. Tong ,
C. Y. Leung ,
Martin W. Pak  and
C. Andrew van Hasselt
Peter K. M. Ku
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
Michael C. F. Tong
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
C. Y. Leung
Affiliation:
Department of Pathology, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong.
Martin W. Pak
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
C. Andrew van Hasselt*
Affiliation:
Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
*
Address for correspondence: Professor Charles Andrew van Hasselt, Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. Fax: (852)-26466312
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Abstract

Two cases of Rosai-Dorfman disease with polypoid nasal infiltration mimicking nasal tuberculosis and malignant lymphoma are reported. This rare benign disease was first described by Rosai and Dorfman in 1969 and is characterized by histiocytic proliferation. It is seldom considered in the differential diagnosis of granulomatous diseases due to its rarity and histological similarity to other diseases. Extranodal manifestations of this disease are uncommon. Although no specific treatment can guarantee a sustained remission of this disease, surgery for loco-regional lesions can result in long-term symptomatic control and restoration of function. Both patients underwent endoscopic resection of the nasal polypoid lesions and have subsequently been free of recurrence. Loco-regional infiltration of the nasal cavity by Rosai-Dorfman disease is effectively managed by endoscopic resection.

Keywords

HistiocytosissinusNasal polypsSurgery, endoscopic
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 3 , March 1999 , pp. 275 - 280
Copyright
Copyright © JLO (1984) Limited 1999

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