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Laryngeal Kaposi's sarcoma in patients with AIDS

Published online by Cambridge University Press:  29 June 2007

George Mochloulis ,
Richard M. Irving ,
Henry R. Grant  and
Robert F. Miller
George Mochloulis*
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Richard M. Irving
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Henry R. Grant
Affiliation:
Department of Otolaryngology, University College London Hospitals (NHS) Trust, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
Robert F. Miller
Affiliation:
Division of Pathology and Infectious Diseases, UCLMS Middlesex Hospital Site, Mortimer Street, London, UK
*
Address for correspondence: Dr D. Mochloulis, 8 Brendon Villas, Highfield Road, Winchmore Hill, London N21 3HP.
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Abstract

Over a period of 10 years 17 human immunodeficiency virus(HIV)-infected patients with laryngeal Kaposi's sarcoma were seen and treated at University College London Hospitals. All patients had advanced HIV disease. Their presentation was with symptoms of upper airway obstruction in the majority of cases and the diagnosis was made by fibreoptic examination of the larynx. Biopsy was associated with brisk haemorrhage in one patient, who required a temporary tracheostomy, and was not performed in the other 16 cases. The commonest site of laryngeal involvement was the supraglottis in 11 patients, with glottic lesions noted in eight patients: subglottic lesions were seen in only three. Treatment of laryngeal Kaposi's sarcoma was, in general, conservative, five patients received low dose radiotherapy to the larynx and 10 were treated with systemic chemotherapy for disseminated Kaposi's sarcoma. Laryngeal Kaposi's sarcoma did not contribute to patient mortality.

Keywords

SarcomaKaposi'sLaryngeal neoplasmsAcquired immunodeficiency syndromeHIV infectionsRadiotherapyDrug therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 11 , November 1996 , pp. 1034 - 1037
Copyright
Copyright © JLO (1984) Limited 1996

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