Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-26T17:12:25.519Z Has data issue: false hasContentIssue false
  • English
  • Français

kikuchi–Fujimoto disease: a report of two cases and an overview

Published online by Cambridge University Press:  29 June 2007

N. Louis ,
M. Hanley  and
N. McD. Davidson
N. Louis*
Affiliation:
Departments of Surgery, North-West Armed Forces Hospital, PO Box 100, Tabuk, Saudi Arabia.
M. Hanley
Affiliation:
Departments of Surgery, North-West Armed Forces Hospital, PO Box 100, Tabuk, Saudi Arabia.
N. McD. Davidson
Affiliation:
Departments of Pathology and Internal Medicine, North-West Armed Forces Hospital, PO Box 100, Tabuk, Saudi Arabia.
*
Dr N. Louis, Senior Consultant ENT Surgeon, Department of Surgery, NWAF Hospital, PO Box 100, Tabuk, Saudi Arabia. Fax: 966–4–423–2795
Get access Rights & Permissions [Opens in a new window]

Abstract

Kikuchi-Fujimoto disease (KFD) has been widely reported from Japan and sporadically from many parts of the world including Saudi Arabia, since its original description in 1972 but the disease remains poorly known by clinicians. In this paper we report two Saudi patients seen in Tabuk. Saudi Arabia. One was a 36-year-old Saudi man and the other a 16-yearold Saudi girl. Both presented with cervical lymphadenopathy and pyrexia. Histological examination of biospy material from both showed classical features of KFD. Other laboratory findings were unremarkable except for leucopenia. Following excision biopsy both patients recovered without sequelae. KFD is a self-limiting process of uncertain aetiology that predominantly affects young women aged 20–-30 years. We review the pathology, clinical featuers and possible aetiology of this interesting disease, which may well be underdiagnosed. Increased awareness of KFD will minimize the risk of confusing this entity with malignant lymphoma or other serious conditions.

Keywords

Lymphadenitisnecrotizing histiocytic
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 11 , November 1994 , pp. 1001 - 1004
Copyright
Copyright © JLO (1984) Limited 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bowness, P., Dutoit, S. H. (1988) Kukuchi's disease as a cause of fever and cervical lymphadenopathy. Journal of Infection 16: 310–311.CrossRefGoogle ScholarPubMed
Chamulak, G. A., Brynes, R. K., Nathwanti, B. N. (1990) Kukuchi-Fujimoto disease mimicking malignant lymphoma. American Journal of Surgical Pathology 14: 514–523.CrossRefGoogle Scholar
Chan, J. K. C., Wong, K.-C., Ng, C.-S. (1989) A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer 63: 1856–1862.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Dorfman, R. F., Berry, G. J. (1988) Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Seminars in Diagnostic Pathology 5: 329–345.Google ScholarPubMed
Fujimori, T., Shioda, K., Sussman, E. B., Miura, M., Katayama, I. (1981) Subacute necrotising lymphadenitis: a clinicopathologic study. Acta Pathologica Japonica 31: 791–797.CrossRefGoogle ScholarPubMed
Fujimoto, Y., Kojima, Y., Yamaguchi, K. (1972) Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity. Naika 30: 920–927 (in Japanese).Google Scholar
Garcia, C. E., Girdhar-Gopal, H. V., Dorfman, D. M. (1993) Kikuchi–Fujimoto disease of the neck: update. Annals of Otology, Rhinology and Laryngology 102: 11–15.CrossRefGoogle ScholarPubMed
Gleeson, M. J., Siodlak, M. Z., Barbatis, C., Salama, N. Y. (1985) Kikuchi 's—a new cause of cervical lymphadenopathy. Journal of Laryngology and Otology 99: 935–939.CrossRefGoogle Scholar
Imamura, M., Ueno, H., Matsuura, A., Kamiya, H., Suzuki, T., Kikuchi, K., Onoe, T. (1982) An ultrastructual study of subacute necrotizing lymphadenitis. American Journal of Pathology 107: 292–299.Google Scholar
Khan, A. R. (1990) Kikuchi's histiocytic necrotizing lymphadenitis: report of a case. Annals of Saudi Medicine 10: 460–464.CrossRefGoogle Scholar
Kikuchi, M. (1972) Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: a clinicopathological study. Nippon Ketsueki Gakkai Zasshi 35: 379–380 (in Japanese).Google Scholar
Kikuchi, M. (1979) Lymphadenopathy due to toxoplasmic infection and anti-convulsant. Recent Advances in RES Research 18: 97–123.Google Scholar
Kutty, M. K., Anim, J. T., Sowayan, S. (1991) Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease) in Saudi Arabia. Tropical and Geographical Medicine 43: 68–75.Google ScholarPubMed
Morad, N., Malatani, T., Khan, A. R., Hussain, N. (1992) Peripheral lymphadenopathy as a primary presenting sign: a study of 324 cases from Asir region. Annals of Saudi Medicine 12: 72–75.CrossRefGoogle ScholarPubMed
Nathwani, B. M. (1991) Kikuchi–Fujimoto disease. American Journal of Surgical Pathology 15: 196–198.CrossRefGoogle Scholar
Pileri, S., Kikuchi, M., Helbron, D., Lennert, K. (1982) Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Archiv A: Pathoglogical Anatomy and Histopathology 398: 257–271.CrossRefGoogle Scholar
Rudniki, C., Kessler, E., Zarfati, M., Turani, H., Bar-Ziv, Y., Zahavi, I. (1988) Kikuchi's necrotizing lymphadenitis: a cause of fever of unknown origin and splenomegaly. Acta Haematologica 79: 99–102.CrossRefGoogle ScholarPubMed
Smith, K. G. C., Becker, G. J., Busmanis, I. (1992) Recurrent Kikuchi's disease. Lancet 340: 124.CrossRefGoogle ScholarPubMed
Turner, R. R., Martin, J., Dorfman, R. F. (1983) Necrotizing lymphadenitis: a study of 30 cases. American Journal of Surgical Pathology 7: 115–123.CrossRefGoogle ScholarPubMed
Unger, P. D., Rappaport, K. M., Strauchen, J. A. (1987) Necrotizing lymphadenitis (Kikuchi's disease): report of four cases of an unusual pseudolymphomatous lesion and immunological marker studies. Archives of Pathology and Laboratory Medicine 111: 1031–1034.Google Scholar
Wakasa, H., Takahashi, H., Kimura, N. (1979) Necrotizing lymphadenitis. Recent Advances in RES Research 18: 85–96.Google Scholar