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Is celecoxib a useful adjunct in the treatment of post-tonsillectomy pain in the adult population? A randomised, double-blind, placebo-controlled study

Published online by Cambridge University Press:  06 February 2017

T-T Ng ,
D Diamantaras ,
J Priestley ,
J Redman ,
N De Silva  and
V Mahanta
T-T Ng*
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
D Diamantaras
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
J Priestley
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
J Redman
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
N De Silva
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
V Mahanta
Affiliation:
ENT Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, Australia
*
Address for correspondence: Dr T-T Ng, Department of Surgery, Peninsula Health, PO Box 52, Hastings Road, Frankston 3199, Australia E-mail: [email protected]
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Abstract

Objective:

To evaluate the efficacy and safety of celecoxib for pain management in post-tonsillectomy adult patients.

Design:

A randomised, double-blind, placebo-controlled, phase 3 clinical trial was conducted in an adult population (aged 18–55 years), with a parallel group design using an allocation ratio of 1:1.

Methods:

Eighty patients underwent elective tonsillectomy or adenotonsillectomy, operated on by one surgeon. They were discharged home with randomly assigned celecoxib or placebo, together with regular post-tonsillectomy medications (paracetamol and Endone). Pain scores were measured from post-operative days 1 to 10. All patients were assessed on post-operative days 5, 12 and 28.

Results:

There were no statistically significant differences in the daily or overall pain scores, the total intake of Endone, or the time taken to achieve freedom from pain after tonsillectomy between the study arms (n = 40 each arm). The celecoxib-treated group experienced significantly more vomiting (celecoxib vs placebo p < 0.001 (Mann–Whitney test), confidence interval = 0.57 to 0.76).

Conclusion:

Celecoxib usage was associated with significantly more vomiting and did not reduce narcotic analgesia requirement post-tonsillectomy.

Keywords

TonsillectomyPostoperative ComplicationsHemorrhageProspective StudiesDouble-Blind MethodCyclooxygenase 2 InhibitorsCelecoxibAnalgesia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Supplement S1 , January 2017 , pp. S18 - S28
Copyright
Copyright © JLO (1984) Limited 2017 

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Footnotes

Presented orally at the 68th Annual General and Scientific Meeting of the New Zealand Society of Otolaryngology, Head and Neck Surgery, 20–23 October 2015, Nelson, New Zealand.

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