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Intranasal corticosteroid and oxymetazoline for chronic rhinitis: a systematic review

Published online by Cambridge University Press:  27 October 2021

C L Neighbors ,
C Fernandez Salvador ,
B Zhu ,
M Camacho  and
P Tsai
C L Neighbors*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tripler Army Medical Center, Honolulu, USA
C Fernandez Salvador
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Fort Bragg Medical Center, USA
B Zhu
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tripler Army Medical Center, Honolulu, USA
M Camacho
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tripler Army Medical Center, Honolulu, USA
P Tsai
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tripler Army Medical Center, Honolulu, USA
*
Author for correspondence: Dr C L Neighbors, Department of Otolaryngology – Head and Neck Surgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu 96859, Hawaii, USA E-mail: [email protected]
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Abstract

Objective

This study aimed to summarise the evidence for efficacy of combination treatment of intranasal corticosteroid spray with oxymetazoline hydrochloride nasal spray for chronic rhinitis.

Method

Nine databases were systematically searched from study inception in September 2016 to 1 June 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed.

Results

A total of 130 studies were screened, and 4 randomised controlled trials comprising 838 patients met inclusion criteria. The study found superior improvement of nasal congestion from onset of treatment to completion in intranasal corticosteroid spray and oxymetazoline hydrochloride groups compared with control groups. Intranasal corticosteroid spray and oxymetazoline hydrochloride use resulted in higher nasal volume (standard error of mean 1, 15.8 + 1.1 ml; p < .03) compared with either placebo (12.1 + 0.9 ml) or oxymetazoline hydrochloride (12.4 + 0.8 ml) alone (p = 0.003).

Conclusion

Intranasal corticosteroid spray and oxymetazoline hydrochloride combination treatment may be superior in reducing rhinitis symptoms compared with either intranasal corticosteroid spray or oxymetazoline hydrochloride alone, without inducing rhinitis medicamentosa.

Keywords

OxymetazolineRhinitis MedicamentosaNasal Corticosteroid
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 1 , January 2022 , pp. 8 - 16
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr C L Neighbors takes responsibility for the integrity of the content of the paper

Presented at the American Academy of Otolaryngology Head and Neck Society Annual Meeting, 10 September 2017, Chicago, Illinois, USA.

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