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Human papilloma virus prevalence in laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  26 February 2007

A Gungor ,
H Cincik ,
H Baloglu ,
E Cekin ,
S Dogru  and
E Dursun
A Gungor
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
H Cincik*
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
H Baloglu
Affiliation:
Department of Pathology, Gulhane military medical academy, Haydarpasa Educational Hospital, Istanbul, Turkey.
E Cekin
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
S Dogru
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
E Dursun
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
*
Address for correspondence: Dr Hakan Cincik, GATA Haydarpasa Egitim Hastanesi KBB Klinigi, Kadıkoy 34668, Istanbul, Türkiye. Fax: +90 216 348 78 80 E-mail: [email protected]
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Abstract

Purpose:

To determine the prevalence and type of human papilloma virus deoxyribonucleic acid (DNA) in cases of laryngeal squamous cell carcinoma.

Methods:

We analysed the prevalence of human papilloma virus infection in archived paraffin block specimens taken from 99 cases of laryngeal squamous cell carcinoma between 1990 and 2005, using polymerase chain reaction techniques. Biopsy specimens from five proven verrucous skin lesions were used as positive controls, and peripheral blood samples from five healthy volunteers were used as negative controls.

Results:

Four test samples were found to have inadequate deoxyribonucleic acid purity and were therefore excluded from the study. Human papilloma virus deoxyribonucleic acid was detected in seven of 95 cases of laryngeal squamous cell carcinoma (7.36 per cent). Human papilloma virus genotyping revealed double human papilloma virus infection in three cases and single human papilloma virus infection in the remaining four cases. The human papilloma virus genotypes detected were 6, 11 and 16 (the latter detected in only one case).

Conclusion:

In our series, a very low human papilloma virus prevalence was found among laryngeal squamous cell carcinoma cases. The human papilloma virus genotypes detected were mostly 6 and/or 11, and 16 in only one case. To the best of our knowledge, this is the first report of human papilloma virus prevalence in laryngeal squamous cell carcinoma, based on polymerase chain reaction genotyping in a Turkish population.

Keywords

Human Papilloma VirusLaryngeal NeoplasmsPapillomas
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 8 , August 2007 , pp. 772 - 774
Copyright
Copyright © JLO (1984) Limited 2007

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References

1Syrjanen, S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol 2005;32:59–66CrossRefGoogle ScholarPubMed
2Fischer, M, Winterfeld, FV. Evaluation and application of a broad-spectrum polymerase chain reaction assay for human papillomaviruses in the screening of squamous cell tumours of the head and neck. Acta Otolaryngol 2003;123:752–8CrossRefGoogle ScholarPubMed
3Mork, J, Lie, AK, Glattre, E, Hallmans, G, Jellum, E, Koskela, P et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001;344:1125–31CrossRefGoogle ScholarPubMed
4Gorgoulis, VG, Zacharatos, P, Kotsinas, A, Kyroudi, A, Rassidakis, AN, Ikonomopoulos, JA et al. Human papillomavirus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis. Hum Pathol 1999;30:274–83CrossRefGoogle ScholarPubMed
5Hobbs, CGL, Birchall, MA. Human papillomavirus infection in the etiology of laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 2004;12:88–92CrossRefGoogle ScholarPubMed
6Syrjanen, K, Syrjanen, S, Pyrhonen, S. Human papilloma virus (HPV) antigens in lesions of laryngeal squamous cell carcinomas. ORL J Otorhinolaryngol Relat Spec 1982;44:323–34CrossRefGoogle ScholarPubMed
7Lindeberg, H, Krogdahl, A. Laryngeal cancer and human papillomavirus: HPV is absent in the majority of laryngeal carcinomas. Cancer Lett 1999;146:9–13CrossRefGoogle ScholarPubMed
8Badaracco, G, Venuti, A, Morello, R, Muller, A, Marcante, ML. Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parameters. Anticancer Res 2000;20:1301–5Google ScholarPubMed
9Mineta, H, Ogino, T, Amano, HM, Ohkawa, Y, Araki, K, Takebayashi, S et al. Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma. Anticancer Res 1998;18:4765–8Google ScholarPubMed
10Mounts, P, Shah, KV, Kashima, H. Viral etiology of juvenile- and adult-onset squamous papilloma of the larynx. Proc Natl Acad Sci U S A 1982;79:5425–9CrossRefGoogle ScholarPubMed
11DiLorenza, TP, Steinberg, BM. Differential regulation of human papillomavirus type 6 and 11 early promoters in cultured cells derived from laryngeal papillomas. J Virol 1995;69:6865–72CrossRefGoogle Scholar
12Nunez, DA, Astley, SM, Lewis, FA, Wells, M. Human papilloma viruses: a study of their prevalence in the normal larynx. J Laryngol Otol 1994;108:319–20CrossRefGoogle ScholarPubMed
13Perez-Ayala, M, Ruiz-Cabello, F, Esteban, F, Concha, A, Rodondo, M, Oliva, MR et al. Presence of HPV 16 sequences in laryngeal carcinomas. Int J Cancer 1990;46:8–11CrossRefGoogle ScholarPubMed
14Garcia-Milian, R, Hernandez, H, Panade, L, Rodriquez, C, Gonzalez, N, Valenzuela, C et al. Detection and typing of human papillomavirus DNA in benign and malignant tumours of laryngeal epithelium. Acta Otolaryngol (Stockh) 1998;118:754–8Google ScholarPubMed
15Fouret, P, Monceaux, G, Temam, S, Lacourreye, L, St Guily, JL. Human papillomavirus in head and neck squamous cell carcinomas in nonsmokers. Arch Otolaryngol Head Neck Surg 1997;123:513–16CrossRefGoogle ScholarPubMed
16Kreimer, AR, Clifford, GM, Boyle, P, Franceschi, S. Human papillomavirus in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005;14:467–75CrossRefGoogle ScholarPubMed
17Hobbs, CGL, Sterne, JAC, Bailey, M, Heyderman, RS, Birchall, MA, Thomas, SJ. Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol 2006;31:259–66CrossRefGoogle ScholarPubMed
18Herrero, R, Castellsague, X, Pawlita, M, Lissowska, J, Kee, F, Balaram, P et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 2003;95:1772–83CrossRefGoogle ScholarPubMed