Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T15:37:02.928Z Has data issue: false hasContentIssue false
  • English
  • Français

Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study

Published online by Cambridge University Press:  03 September 2014

G Malkoc ,
A Dalgic ,
M Koc ,
T Kandogan ,
S Korkmaz ,
M E Ceylan ,
S Inan  and
L Olgun
G Malkoc
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
A Dalgic*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
M Koc
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
T Kandogan
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Tepecik Research and Training Hospital, Turkey
S Korkmaz
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
M E Ceylan
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
S Inan
Affiliation:
Department of Histology and Embryology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
L Olgun
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Turkey
*
Address for correspondence: Dr Abdullah Dalgic, Department of Otolaryngology, Head and Neck Surgery, Izmir Bozyaka Research and Training Hospital, Saim Cikrikci Cad. No: 59 Bozyaka, Izmir 35170, Turkey Fax: +90 232 2505050 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application.

Method:

The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 µg/ml dexamethasone.

Results:

Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone.

Conclusion:

The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma.

Keywords

Round Window, EarCochlear ImplantationCorticosteroidsRats
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 8 , August 2014 , pp. 702 - 708
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented orally at the 2nd National Congress of Otology and Neurotology, 10–13 May 2012, Antalya, Turkey.

References

1Eshraghi, AA, Hodges, AV, Telischi, FF, Balkany, TJ. Cochlear implant technology. In: Jackler, R, Brachman, DE, eds. Textbook of Neurotology. Philadelphia: Elsevier, 2005;1301–14CrossRefGoogle Scholar
2Boggess, WJ, Baker, JE, Balkany, TJ. Loss of residual hearing after cochlear implantation. Laryngoscope 1989;99:203–6Google Scholar
3Mazurek, B, Amarjargal, N, Haupt, H, Fuchs, J, Olze, H, Machulik, A et al. Expression of genes implicated in oxidative stress in the cochlea of newborn rats. Hear Res 2011;277:54–60Google Scholar
4Eshraghi, AA, Yang, N, Balkany, TJ. Comparative study of cochlear damage with three perimodiolar electrode designs. Laryngoscope 2003;113:415–19Google Scholar
5Gantz, BJ, Turner, C, Gfeller, KE, Lowder, MW. Preservation of hearing in cochlear implant surgery: advantages of combined electrical and acoustical speech processing. Laryngoscope 2005;115:796–802Google Scholar
6Li, PM, Wang, H, Northrop, C, Merchant, SN, Nadol, JB Jr.Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures. Otol Neurotol 2007;28:641–8CrossRefGoogle ScholarPubMed
7Gomaa, NA, Rubinstein, JT, Lowder, MW, Tyler, RS, Gantz, BJ. Residual speech perception and cochlear implant performance in postlingually deafened adults. Ear Hear 2003;24:539–44Google Scholar
8Wang, J, Van De Water, TR, Bonny, C, de Ribaupierre, F, Puel, JL, Zine, A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003;23:8596–607Google Scholar
9Eshraghi, AA, Adil, E, He, J, Graves, R, Balkany, TJ, Van De Water, TR. Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss. Otol Neurotol 2007;28:842–9CrossRefGoogle Scholar
10Yildirim, A, Coban, L, Satar, B, Yetiser, S, Kunt, T. Effect of intratympanic dexamethasone on noise-induced temporary threshold shift. Laryngoscope 2005;115:1219–22Google Scholar
11Eshraghi, AA, He, J, Mou, CH, Polak, M, Zine, A, Bonny, C et al. D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma. Otol Neurotol 2006;27:504–11Google Scholar
12Dinh, CT, Haake, S, Chen, S, Hoang, K, Nong, E, Eshraghi, AA et al. Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes. Neuroscience 2008;157:405–13Google Scholar
13Van De Water, TR, Abi Hachem, RN, Dinh, CT, Bas, E, Haake, SM, Hoosien, G et al. Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. Cochlear Implants Int 2010;11:42–55Google Scholar
14Kirkegaard, M, Murai, N, Risling, M, Suneson, A, Järlebark, L, Ulfendahl, M. Differential gene expression in the rat cochlea after exposure to impulse noise. Neuroscience 2006;42:425–35Google Scholar
15Dagli, S. Distortion product otoacoustic emissions, input/output curves. Kulak Burun Bogaz ve Bas Boyun Cerrahisi Dergisi 4:2-140-142Google Scholar
16Takemura, K, Komeda, M, Yagi, M, Himeno, C, İzumikava, M, Doi, T et al. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in the guinea pig. Hear Res 2004;196:56–68CrossRefGoogle Scholar
17Tabuchi, K, Murashita, H, Tobita, T, Oikawa, K, Tsuji, S, Uemaetomari, I et al. Dehydroepiandrosteronesulfate reduces acoustic injury of the guinea-pig cochlea. J Pharmacol Sci 2005;99:191–4Google Scholar
18Parham, K. Can intratympanic dexamethasone protect against cisplatin ototoxicity in mice with age-related hearing loss? Otolaryngol Head Neck Surg 2011;145:635–40Google Scholar
19Eshraghi, AA, Polak, M, He, J, Telischi, FF, Balkany, TJ, Van De Water, TR. Pattern of hearing loss in a rat model of cochlear implantation trauma. Otol Neurotol 2005;26:442–7CrossRefGoogle Scholar