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Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland

Published online by Cambridge University Press:  29 June 2007

Masashi Suzuki ,
Issei Ichimiya ,
Futoshi Matsushita  and
Goro Mogi
Masashi Suzuki
Affiliation:
Department of Otolaryngology, Oita Medical University, Oita, Japan.
Issei Ichimiya
Affiliation:
Department of Otolaryngology, Oita Medical University, Oita, Japan.
Futoshi Matsushita
Affiliation:
Department of Otolaryngology, Oita Medical University, Oita, Japan.
Goro Mogi*
Affiliation:
Department of Otolaryngology, Oita Medical University, Oita, Japan.
*
Address for correspondence: Goro Mogi, M. D., Department of Otolaryngology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. Fax: 097-549-0762
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Abstract

Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland were analysed. Tumours from 13 patients were classified according to histological grades and immunoreactivity for HEK-2/neu. Surgical resection of the tumour was performed for all patients, and the overall five-year survival rate was 69 per cent. The patients whose histological grades were 1 or 2 showed a 100 per cent five-year survival rate, but no patient with grade 3 survived five years. Also, patients who had tumours that overexpressed HER-2/new had a lower survival rate (25 per cent) than patients with tumours that had weaker immunostaining (89 per cent). We considered tumours classified as grade 3 plus strong HER-2/neu expression to be ‘high malignancy’, and compared them with ‘low malignancy’ tumours that were grade 1 or 2 and had weaker HER-2/new staining. Patients with high malignancy tumours had shorter recurrence-free intervals and shorter overall survival than patients with low malignancy tumours. The overall survival period of the low malignancy cases was much longer than the recurrence-free interval; unlike that in the high malignancy tumour patients. These results suggest that the combination of histological grades and expression of HER-2/neu may be a useful predictor of the prognosis for mucoepidermoid carcinomata.

Keywords

Parotid neoplasmsImmunohistochemistryNeoplasm stagingSurvival rate
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 10 , October 1998 , pp. 944 - 947
Copyright
Copyright © JLO (1984) Limited 1998

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