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Expression of the cell–cell adhesion molecule E-cadherin in tongue carcinoma cell lines

Published online by Cambridge University Press:  29 June 2007

A. R. Kinsella ,
G. L. Bowie ,
J. K. Fields  and
A. S. Jones
A. R. Kinsella
Affiliation:
Departments of Surgery, University of Liverpool.
G. L. Bowie
Affiliation:
Otolaryngology/Head and Neck Surgery, University of Liverpool
J. K. Fields
Affiliation:
Dental Sciences, University of Liverpool.
A. S. Jones*
Affiliation:
Otolaryngology/Head and Neck Surgery, University of Liverpool
*
Professor A. S. Jones, Department of Otolaryngology/Head and Neck Surgery, University of Liverpool, Royal Liverpool University Hospital, PO Box 147, Liverpool L69 3BX.
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Abstract

A reduction in cell adhesiveness and cell invasion are essential steps in tumour progression. In the present study six tongue carcinoma cell lines were compared with regard to their invasive potential in two in vitro invasion assay systems and for their patterns of expression of the cell–cell adhesion molecule E-cadherin. The three cell lines negative for E-cadherin expression were invasive in both assays. One cell line with strong E-cadherin expression was strongly invasive and one weakly invasive. One cell line with reduced E-cadherin expression was weakly invasive. There was no significant pattern to these findings (x2 = 0.375; p = 0.54). This supports previous studies from this group that suggest that E-cadherin is only one of the presumably many molecules involved in tumour progression in squamous cell carcinoma of the tongue.

Keywords

Carcinoma, squamous cellHead and neck neoplasmsTongueCell adhesion molecules
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 11 , November 1994 , pp. 957 - 961
Copyright
Copyright © JLO (1984) Limited 1994

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