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Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma

Published online by Cambridge University Press:  15 January 2013

S Erbek ,
H Erinanc ,
E Hizal  and
L N Ozluoglu
S Erbek*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey
H Erinanc
Affiliation:
Department of Pathology, Faculty of Medicine, Baskent University, Ankara, Turkey
E Hizal
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey
L N Ozluoglu
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey
*
Address for correspondence: Dr Seyra Erbek, Department of Otolaryngology, Baskent University Hospital, Fevzi Çakmak Cd 10 Sk No 45, 06490 Bahçelievler, Ankara, Turkey Fax: +90 312 223 7333 E-mail: [email protected]
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Abstract

Objective:

Proteases of the disintegrin and metalloproteinase family (also known as ADAM proteins) are involved in various physiological and pathological processes. This study assessed the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma.

Materials and methods:

The study evaluated cholesteatoma specimens from 19 patients, and external ear canal skin samples from 7 of the same patients (as controls), for the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17, using immunohistochemical methods.

Results and analysis:

The study observed over-expression of proteins 10 and 17 in blood vessels, and over-expression of proteins 12 and 17 in cholesteatoma stroma. Immunostaining scores for proteins 10, 12 and 17 in epithelial and inflammatory cells from cholesteatoma specimens versus control specimens showed no statistically significant differences.

Conclusion:

Over-expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma may be related to cholesteatoma pathogenesis. These proteins deserve further study as they may represent potential targets for cholesteatoma treatment.

Keywords

CholesteatomaADAM proteinsADAM-10 protein, humanADAM12 protein, humanADAM17 protein, human
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 2 , February 2013 , pp. 153 - 158
Copyright
Copyright © JLO (1984) Limited 2013

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Footnotes

Presented at the 1st Turkish National Congress of Otology and Neurotology, 12–16 May 2010, Gazimagosa, Cyprus

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