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Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial

Published online by Cambridge University Press:  01 August 2016

S Romsaithong ,
K Tomanakan ,
W Tangsawad  and
S Thanaviratananich
S Romsaithong
Affiliation:
Department of Otolaryngology, Khon Kaen Hospital, Thailand
K Tomanakan
Affiliation:
Department of Medical Technology, Khon Kaen Hospital, Thailand
W Tangsawad
Affiliation:
Department of Otolaryngology, Khon Kaen Hospital, Thailand
S Thanaviratananich*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Thailand
*
Address for correspondence: Dr Sanguansak Thanaviratananich, Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Fax: +66 43 202 490 E-mail: [email protected]
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Abstract

Objectives:

To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis.

Methods:

A total of 120 otomycosis patients were randomly assigned to receive either 1 per cent clotrimazole solution (intervention group) or 3 per cent boric acid in 70 per cent alcohol (control group) at the Khon Kaen Hospital ENT out-patient department. Treatment effectiveness was determined based on the otomicroscopic absence of fungus one week after therapy, following a single application of treatment.

Results:

After 1 week of treatment, there were data for 109 participants, 54 in the clotrimazole group and 55 in the boric acid group. The absolute difference in cure rates between 1 per cent clotrimazole solution and 3 per cent boric acid in 70 per cent alcohol was 17.9 per cent (95 per cent confidence interval, 2.3 to 33.5; p = 0.028) and the number needed to treat was 6 (95 per cent confidence interval, 3.0 to 43.4). Adverse events for the two agents were comparable.

Conclusion:

One per cent clotrimazole solution is more effective than 3 per cent boric acid in 70 per cent alcohol for otomycosis treatment.

Keywords

Boric AcidsClotrimazoleOtomycosisOtitis ExternaMycosesAntifungal Agents
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 811 - 815
Copyright
Copyright © JLO (1984) Limited 2016 

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