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Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity

Published online by Cambridge University Press:  04 September 2012

M Topdag ,
M Iseri ,
E Gelenli ,
M Yardimoglu ,
Y Yazir ,
S A Ulubil ,
D O Topdag  and
E Ustundag
M Topdag*
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
M Iseri
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
E Gelenli
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
M Yardimoglu
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
Y Yazir
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
S A Ulubil
Affiliation:
Acibadem Fulya Hospital, Department of Otolaryngology, Istanbul, Turkey
D O Topdag
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
E Ustundag
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
*
Address for correspondence: Dr Murat Topdag, Kocaeli Universitesi Tip Fakultesi Hastanesi KBB ABD, Umuttepe, Kocaeli 41380, Turkey Fax: +90 262 303 8003 E-mail: [email protected]
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Abstract

Objective:

This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals.

Material and methods:

This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats.

Results:

Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05).

Conclusion:

Dexamethasone and memantine were found superior to piracetam in reducing apoptosis due to cisplatin ototoxicity. Further studies of this subject are needed, incorporating electron microscopy and auditory brainstem response testing.

Keywords

Ear, InnerRatOtotoxicityDexamethasoneMemantinePiracetam
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 11 , November 2012 , pp. 1091 - 1096
Copyright
Copyright © JLO (1984) Limited 2012

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