Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-20T04:02:08.810Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of cetirizine on symptoms and signs of nasal polyposis

Published online by Cambridge University Press:  29 June 2007

Rolf Haye ,
Jens P. Aanesen ,
Bernard Burtin ,
Fergal Donnelly  and
Christian Duby
Rolf Haye*
Affiliation:
Department of Otolaryngology, Rikshospitalet, Oslo, Norway
Jens P. Aanesen
Affiliation:
Department of Otolaryngology, Rikshospitalet, Oslo, Norway
Bernard Burtin
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
Fergal Donnelly
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
Christian Duby
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
*
Address for correspondence: Rolf Haye, M.D., Department of Otolaryngology, Rikshospitalet, 0027 Oslo, Norway. Fax: +47 – 22 86 96 35
Get access Rights & Permissions [Opens in a new window]

Abstract

Forty-five patients with residual or recurrent nasal polyposis after ethmoidectomy were treated with either cetirizine at twice the daily recommended (20 mg) dose or placebo for three months. The number and size of polyps remained unchanged during the study period. Cetirizine was found to reduce nasal sneezing and rhinorrhoea effectively. The drug also had a beneficial effect on nasal obstruction in the latter part of the study. The side effects of 20 mg (double the recommended daily adult dose) of cetirizine were few and comparable to placebo.

Keywords

Nasal polypsHistamine H1 receptor blockaders
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 11 , November 1998 , pp. 1042 - 1046
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bagnasco, M., Canonica, G. W. (1995) Influence on H1-receptor antagonists on adhesion molecules and cellular traffic. Allergy 50: 17–23.CrossRefGoogle ScholarPubMed
Bumstead, R., El-Ackad, T., Montgomery Smith, J., Brody, M. (1979) Histamine, norepinephrine and serotonin content of nasal polyps. Laryngology 89: 832–843.Google Scholar
van Camp, C., Clement, P. A. R. (1994) Results of oral steroid treatment in nasal polyposis. Rhinology 32: 5–9.Google ScholarPubMed
Cauna, N., Hinderer, K. H., Manzetti, G. W., Swanson, E. W. (1972) Fine structure of nasal polyps. Annals of Otology 81: 41–58.Google ScholarPubMed
Charlesworth, E. N., Kagey-Sobotka, A., Norman, P. S., Lichtenstein, L. M. (1989) Effect of cetirizine on mast cell mediator release and cellular traffic during the cutaneous late-phase reaction. Journal of Allergy and Clinical Immunology 83: 905–912.CrossRefGoogle ScholarPubMed
Ciprandi, G., Pronzato, C., Fasce, L., Tosca, M. A., Cozzani, S., Grimaldi, I., Canonica, G. W. (1995) Antiallergic activity of cetirizme in the treatment of mite allergy in children. Allergy (Suppl. 26): 104.Google Scholar
Drake-Lee, A. B. (1994) Medical treatment of nasal polyps. Rhinology 32: 1–4.Google ScholarPubMed
Drake-Lee, A. B., Barker, T., Thyrley, K. (1984) Clinical profile and recurrence of nasal polyps. Journal of Laryngology and Otology 98: 783–793.CrossRefGoogle ScholarPubMed
Fadel, R., Herpin-Richard, N., Rihoux, J.-P., Henocq, E. (1987) Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo. Clinical Allergy 17: 373–379.CrossRefGoogle ScholarPubMed
Fasce, L., Ciprandi, G., Pronzato, C., Cozzani, S., Tosca, M. A., Grimaldi, I., Canonica, G. W. (1996) Cetirizine reduces ICAM-1 on epithelial cells during nasal minimal persistent inflammation in asymptomatic children in mite-allergic asthma. International Archives of Allergy and Immunology 109: 272–276.CrossRefGoogle ScholarPubMed
Haye, R., Aanesen, J. P., Jahnsen, F. L., Burtin, B., Duby, C. (1995) Effect of cetirizine on nasal polyps and their associated symptoms. Allergy (Suppl 103): P–0067.Google Scholar
Jahnsen, F. L., Haraldsen, G., Aanesen, J. P., Haye, R., Brantzæg, P. (1995) Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps. American Journal of Respiratory Cell and Molecular Biology 12: 624–632.CrossRefGoogle ScholarPubMed
Lildholdt, T., Fogstrup, J., Kortholm, B. B., Ulsoe, C. (1988) Surgical versus medical treatment of nasal polyps. Acta Oto-Laryngologica (Stockh) 105: 104–113.Google ScholarPubMed
Moloney, J. R. (1977) Nasal polyps, nasal polypectomy, asthma and aspirin sensitivity: their association in 445 cases of nasal polyps. Journal of Laryngology and Otology 91: 837–846.CrossRefGoogle ScholarPubMed
Slavin, R. G. (1992) Allergy is not a significant cause of nasal polyps. Archives of Otolaryngology 21: 60–65.Google Scholar