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Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study

Published online by Cambridge University Press:  23 May 2016

M Kara ,
H Erdoğan ,
H B Altinişik ,
H Aylanç ,
O Güçlü  and
F S Dereköy
M Kara*
Affiliation:
Department of Otorhinolaryngology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
H Erdoğan
Affiliation:
Department of Otorhinolaryngology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
H B Altinişik
Affiliation:
Department of Anesthesiology and Reanimation, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
H Aylanç
Affiliation:
Department of Pediatry, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
O Güçlü
Affiliation:
Department of Otorhinolaryngology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
F S Dereköy
Affiliation:
Department of Otorhinolaryngology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
*
Address for correspondence: Dr Medine Kara, Department of Otorhinolaryngology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey E-mail: [email protected]
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Abstract

Background:

To evaluate the effects of autologous serum usage on throat pain, haemorrhage and tonsillar fossa epithelisation in patients after tonsillectomy.

Methods:

Thirty-two patients (aged 4–15 years) were included in the study. Tonsillectomy was performed and autologous serum was administered topically to the right tonsillar fossa during the operation, and at 8 and 24 hours post-operatively. The left side served as the control. A visual analogue scale was used to record the patient's pain every day. Each patient's oropharynx was observed on the 5th and 10th post-operative days to examine bleeding and epithelisation.

Results:

The pain scores for the side administered autologous serum were significantly lower than those for the control side, on the night following the operation and on the 1st, 2nd, 5th and 6th post-operative days. Tonsillar fossa epithelisation was significantly accelerated on the study side compared with the control side on the 5th and 10th post-operative days.

Conclusion:

In tonsillectomy patients, topically administered autologous serum contributed to throat pain relief and tonsillar fossa epithelisation during the post-operative period.

Keywords

TonsillectomySerumPostoperative PainWound HealingHemorrhage
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 7 , July 2016 , pp. 662 - 668
Copyright
Copyright © JLO (1984) Limited 2016 

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References

1Stoeckli, SJ, Moe, KS, Huber, A, Schmid, S.A prospective randomized double-blind trial of fibrin glue for pain and bleeding after tonsillectomy. Laryngoscope 1999;109:652–5CrossRefGoogle ScholarPubMed
2Moralee, SJ, Carney, AS, Cash, MP, Murray, JA.The effect of fibrin sealant haemostasis on post-operative pain in tonsillectomy. Clin Otolaryngol Allied Sci 1994;19:526–38CrossRefGoogle ScholarPubMed
3Nandapalan, V, McIlwain, JC.Tonsillar fossa obliteration and post-operative pain. Clin Otolaryngol Allied Sci 1995;20:127–9CrossRefGoogle ScholarPubMed
4Telian, SA, Handler, SD, Fleisher, GR, Baranak, CC, Wetmore, RF, Potsic, WP.The effect of antibiotic therapy on recovery after tonsillectomy in children: a controlled study. Arch Otolaryngol Head Neck Surg 1986;112:610–15CrossRefGoogle Scholar
5Burkart, CM, Steward, DL.Antibiotics for reduction of posttonsillectomy morbidity: a meta-analysis. Laryngoscope 2005;115:997–1002CrossRefGoogle ScholarPubMed
6Dhiwakar, M, Clement, WA, Supriya, M, McKerrow, W.Antibiotics to reduce post-tonsillectomy morbidity. Cochrane Database Syst Rev 2012;(12):CD005607Google ScholarPubMed
7Uzun, B, Ozkiriş, M, Akbulut, S, Unver, S.The efficacy of preoperative local bupivacain application on postoperative pain in patients who had undergone tonsillectomy [in Turkish]. Kulak Burun Bogaz Ihtis Derg 2009;19:134–7Google ScholarPubMed
8Johansen, M, Harbo, G, Illum, P.Preincisional infiltration with bupivacaine in tonsillectomy. Arch Otolaryngol Head Neck Surg 1996;122:261–3CrossRefGoogle ScholarPubMed
9Kitajiri, S, Tabuchi, K, Hiraumi, H, Kaetsu, H.Relief of post-tonsillectomy pain by release of lidocaine from fibrin glue. Laryngoscope 2001;111:642–4CrossRefGoogle ScholarPubMed
10Mahant, S, Keren, R, Localio, R, Luan, X, Song, L, Shah, SS et al. Dexamethasone and risk of bleeding in children undergoing tonsillectomy. Otolaryngol Head Neck Surg 2014;150:872–9CrossRefGoogle ScholarPubMed
11Magdalena, ML, Caragol, L, Solé, A, Rodrigo, JP.Comparison of two analgesic protocols for post-tonsillectomy pain control in outpatient adults [in Spanish]. Acta Otorrinolaringol Esp 2014;65:102–8CrossRefGoogle ScholarPubMed
12Jahanshahi, J, Pazira, S, Farahani, F, Hashemian, F, Shokri, N, Karkhanei, B et al. Effect of topical sucralfate vs clindamycin on posttonsillectomy pain in children aged 6 to 12 years: a triple-blind randomized clinical trial. JAMA Otolaryngol Head Neck Surg 2014;140:698–703CrossRefGoogle Scholar
13Siupsinskiene, N, Zekonienė, J, Padervinskis, E, Zekonis, G, Vaitkus, S.Efficacy of sucralfate for the treatment of post-tonsillectomy symptoms. Eur Arch Otorhinolaryngol 2015;272:271–8CrossRefGoogle ScholarPubMed
14Miura, MS, Saleh, C, de Andrade, M, Assmann, M, Ayres, M, Lubianca Neto, JF.Topical sucralfate in post-adenotonsillectomy analgesia in children: a double-blind randomized clinical trial. Otolaryngol Head Neck Surg 2009;141:322–8CrossRefGoogle ScholarPubMed
15Ozlugedik, S, Genc, S, Unal, A, Elhan, AH, Tezer, M, Titiz, A.Can postoperative pains following tonsillectomy be relieved by honey? A prospective, randomized, placebo controlled preliminary study. Int J Pediatr Otorhinolaryngol 2006;70:1929–34CrossRefGoogle Scholar
16Soltani, R, Soheilipour, S, Hajhashemi, V, Asghari, G, Bagheri, M, Molavi, M.Evaluation of the effect of aromatherapy with lavender essential oil on post-tonsillectomy pain in pediatric patients: a randomized controlled trial. Int J Pediatr Otorhinolaryngol 2013;77:1579–81CrossRefGoogle ScholarPubMed
17Lombard, B, Tomasi, M, Charpentier, P, Drouet, Y, Salgas, P.Evaluation of transcutaneous electrostimulation in the management of post-tonsillectomy pain in adults [in French]. Rev Laryngol Otol Rhinol (Bord) 1996;117:89–92Google ScholarPubMed
18Ochi, JW.Acupuncture instead of codeine for tonsillectomy pain in children. Int J Pediatr Otorhinolaryngol 2013;77:2058–62CrossRefGoogle ScholarPubMed
19Kaya, FS, Akova, YA.The effect of autologous serum eye drop application on epithelization in the treatment of various ocular surface disorders and its safety. Turk J Ophthalmol 2012;42:336–41CrossRefGoogle Scholar
20Chen, YM, Hu, FR, Huang, JY, Shen, EP, Tsai, TY, Chen, WL.The effect of topical autologous serum on graft re-epithelialization after penetrating keratoplasty. Am J Ophthalmol 2010;150:352–9CrossRefGoogle ScholarPubMed
21Scardovi, C, De Felice, GP, Gazzaniga, A.Epidermal growth factor in the topical treatment of traumatic corneal ulcers. Ophthalmologica 1993;206:119–24CrossRefGoogle ScholarPubMed
22Matsuo, A, Yamazaki, Y, Takase, C, Aoyagi, K, Uchinuma, E.Osteogenic potential of cryopreserved human bone marrow-derived mesenchymal stem cells cultured with autologous serum. J Craniofac Surg 2008;19:693–700CrossRefGoogle ScholarPubMed
23Yanaga, H, Yanaga, K, Imai, K, Koga, M, Soejima, C, Ohmori, K.Clinical application of cultured autologous human auricular chondrocytes with autologous serum for craniofacial nasal augmentation and repair. Plast Reconstr Surg 2006;117:2019–30CrossRefGoogle ScholarPubMed
24Bieri, D, Reeve, RA, Champion, GD, Addicoat, L, Ziegler, JB.The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: development, initial validation, and preliminary investigation for ratio scale properties. Pain 1990;41:139–50CrossRefGoogle ScholarPubMed
25Brodsky, L.Modern assessment of tonsils and adenoids. Pediatr Clin North Am 1989;36:1551–69CrossRefGoogle ScholarPubMed
26Ikoma, R, Sakane, S, Niwa, K, Kanetaka, S, Kawano, T, Oridate, N.Risk factors for post-tonsillectomy haemorrhage. Auris Nasus Larynx 2014;41:376–9CrossRefGoogle Scholar