Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-29T07:58:43.319Z Has data issue: false hasContentIssue false

Delayed brainstem auditory evoked reponses in experimental diabetes mellitus*

Published online by Cambridge University Press:  29 June 2007

N. Buller
Affiliation:
Tel Aviv, Israel
N. Laurian*
Affiliation:
Tel Aviv, Israel
I. shvili
Affiliation:
Tel Aviv, Israel
L. Laurian
Affiliation:
Tel Aviv, Israel
*
Dr. N. Laurian, Dept. of Otolaryngology, Hasharon Hospital, Petah-Tiqva 49372, Israel.

Abstract

The brainstem auditory evoked responses (BAER) were utilized for the evaluation of central neural transmission in alloxan-induced diabetes in rats. The mean latencies of waves I, III, V and the interpeak latencies III-V and I-V were prolonged in diabetic rats as compared to the same rats before alloxan administration. The incidence of abnormal BAER was more frequent in the group of rats with severe diabetes (82 per cent) than in mildly diabetic animals (42 per cent). Our results may suggest the presence of a central neuropathy in experimental diabetes, which can be detected by the method of BAER.

Type
Research Article
Copyright
Copyright © JLO (1984) Limited 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

From the Department of Otolaryngology, Hasharon Hospital, Petah-Tiqva, and Department of Endocrinology, Ichilov Medical Center, Tel Aviv University Medical School, Israel.

References

Chiappa, K. H., and Ropper, A. H. (1980) Evoked potentials in clinical medicine. New England Journal of Medicine, 306: 11401147.CrossRefGoogle Scholar
Clements, R. S., and Bell, S. H. (1982) Diabetic neuropathy. Postgraduate Medicine, 71: 5067.CrossRefGoogle ScholarPubMed
Courjon, J., Mauguiere, F., and Revol, M. (1982) Clinical applications of evoked potentials in neurology. Advances in Neurology, Raven Press, New York.Google Scholar
Cummins, K. L., and Dorfman, L. J. (1981) Nerve fiber conduction velocity distribution: studies of normal and diabetic human nerves. Annals of Neurology, 9: 6774.CrossRefGoogle ScholarPubMed
Donald, M. W., Bird, C. E., El-Sawy, R., Hart, P., Lawson, S., Letemendia, F. J., Surridge, D. H. and Wilson, D. L. (1980) Cortical evoked potentials and auditory decision times of diabetics. Progress in Brain Research, 54: 516521.CrossRefGoogle ScholarPubMed
Donald, M. W., Bird, C. E., Lawson, I. S., Letemendia, F. J. J., Monga, T. N., Surridge, D. H. C., Varette-Cerre, P., Williams, D. L., Williams, D. M. L., and Wilson, D. L. (1981) Delayed auditory brainstem responses in diabetes mcllitus. Journal of Neurology, Neurosurgery, and Psychiatry, 44: 641644.CrossRefGoogle Scholar
Eliasson, S. G. (1964) Nerve conduction changes in experimental diabetes. Journal of Clinical Investigation, 43: 23532358.CrossRefGoogle ScholarPubMed
Eliasson, S. G., and Hughes, A. H. (1960) Cholesterol and fatty acid synthesis in diabetic nerve and spinal cord. Neurology, 10: 143146.CrossRefGoogle ScholarPubMed
Fisher, L. J., and Rickert, D. E. (1975) Pancreatic islet-cell toxicity. CRC Critical Reviews in Toxicology, 3: 231263.CrossRefGoogle Scholar
Gibson, W. P. R. (1978) Essentials of clinical electric response audiometry. Churchill Livingstone, Edinburgh.Google Scholar
Greene, D. A., DeJesus, P. V. Jr, and Winegrad, A. I. (1975) Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. Journal of Clinical Investigation, 55: 13261336.CrossRefGoogle ScholarPubMed
Klebanoff, S. J., and Greenbaum, A. L. (1954) The effect of pH on the diabetogenic action of alloxan. Journal of Endocrinology, 11: 314322.CrossRefGoogle ScholarPubMed
Lazarow, A., and Palay, S. L. (1946) The production and course of alloxan diabetes in the rat. Journal of Laboratory and Clinical Medicine, 31: 10051015.Google ScholarPubMed
Rerup, C. C. (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacologic Reviews, 22: 486502.Google ScholarPubMed
Sharma, A. K., and Thomas, P. K. (1974) Peripheral nerve structure and function in experimental diabetes. Journal of Neurological Science, 23: 115.CrossRefGoogle ScholarPubMed
Stockard, J. J., Stockard, J. E., and Sharbrough, F. W. (1977) Detection and localization of occult lesions with brainstem auditory responses. Mayo Clinic Proceedings, 52: 761769.Google ScholarPubMed
Windebank, A. J. (1963) Diabetic control and peripheral neuropathy. Mayo Clinic Proceedings, 58: 344346.Google Scholar
Winegrad, A. I., Morrison, A. D., and Greene, D. A. (1979) In Textbook of Endocrinology (DeGroot, L. J., ed.), vol. II. pp. 10411055.Google Scholar