Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-26T13:08:55.571Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma

Published online by Cambridge University Press:  11 June 2018

S M Adnan Ali ,
M S Awan ,
S Atif ,
N Ali  and
Y Mirza
S M Adnan Ali*
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
M S Awan
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
S Atif
Affiliation:
Aga Khan Medical College, Aga Khan University, Karachi, Pakistan
N Ali
Affiliation:
Aga Khan Medical College, Aga Khan University, Karachi, Pakistan
Y Mirza
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
*
Address for correspondence: Dr S M Adnan Ali, Office of Academia and Research in Surgery, Department of Surgery, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi 74800, Pakistan Fax: +92 21 3493 4294 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

This study associated Human Papillomavirus (HPV) infection and other clinical parameters with five-year survival of oral squamous cell carcinoma patients at a tertiary care hospital in Karachi, Pakistan.

Methods

A total of 140 patients diagnosed with oral squamous cell carcinoma were enlisted. HPV status and subtypes were established through polymerase chain reaction performed in a previously published study. Clinical data including five-year survival were obtained through institutional medical records.

Results

Ninety-five patients (67.9 per cent) were positive for HPV. Of these, 85 patients were HPV 16 positive while 2 patients were HPV 18 positive. The mean survival time for HPV positive patients was 44.3 months, whereas survival time for HPV negative patients was 46.9 months. Univariate analysis showed that HPV status in oral squamous cell carcinoma was not a statistically significant factor in determining five-year survival rate (p = 0.386).

Conclusion

There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma.

Keywords

Oral PathologySquamous Cell CarcinomaHuman PapillomavirusSurvival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 628 - 635
Copyright
Copyright © JLO (1984) Limited, 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr S M Adnan Ali takes responsibility for the integrity of the content of the paper

References

1GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. In: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx [6 January 2017]Google Scholar
2Markopoulos, AK. Current aspects on oral squamous cell carcinoma. Open Dent J 2012;6:126–30Google Scholar
3de Camargo Cancela, M, Voti, L, Guerra-Yi, M, Chapuis, F, Mazuir, M, Curado, MP. Oral cavity cancer in developed and in developing countries: population-based incidence. Head Neck 2010;32:357–67Google Scholar
4Pytynia, KB, Dahlstrom, KR, Sturgis, EM. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol 2014;50:380–6Google Scholar
5Psyrri, A, DiMaio, D. Human papillomavirus in cervical and head-and-neck cancer. Nat Clin Prac Oncol 2008;5:24–31Google Scholar
6Mork, J, Lie, AK, Glattre, E, Hallmans, G, Jellum, E, Koskela, P et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001;344:1125–31Google Scholar
7Chaturvedi, AK, Engels, EA, Pfeiffer, RM, Hernandez, BY, Xiao, W, Kim, E et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011;29:4294–301Google Scholar
8Dayyani, F, Etzel, CJ, Liu, M, Ho, CH, Lippman, SM, Tsao, AS. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 2010;2:15Google Scholar
9Chung, CH, Gillison, ML. Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res 2009;15:6758–62Google Scholar
10Ang, KK, Harris, J, Wheeler, R, Weber, R, Rosenthal, DI, Nguyen-Tan, PF et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24–35Google Scholar
11Ali, SM, Awan, MS, Ghaffar, S, Salahuddin, I, Khan, S, Mehraj, V et al. Human papillomavirus infection in oral squamous cell carcinomas: correlation with histologic variables and survival outcome in a high risk population. Oral Surgery 2008;1:96–105Google Scholar
12Umudum, H, Rezanko, T, Dag, F, Dogruluk, T. Human papillomavirus genome detection by in situ hybridization in fine-needle aspirates of metastatic lesions from head and neck squamous cell carcinomas. Cancer Cytopathol 2005;105:171–7Google Scholar
13Gillison, ML, Koch, WM, Capone, RB, Spafford, M, Westra, WH, Wu, L et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000;92:709–20Google Scholar
14Tural, D, Elicin, O, Batur, S, Arslan, D, Oz, B, Serdengecti, S et al. Human papillomavirus is independent prognostic factor on outcome of oropharyngeal squamous cell carcinoma. Tumour Biol 2013;34:3363–9Google Scholar
15Benson, E, Li, R, Eisele, D, Fakhry, C. The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas. Oral Oncol 2014;50:565–74Google Scholar
16Ritchie, JM, Smith, EM, Summersgill, KF, Hoffman, HT, Wang, D, Klussmann, JP et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 2003;104:336–44.Google Scholar
17Krüger, M, Pabst, AM, Walter, C, Sagheb, K, Günther, C, Blatt, S et al. The prevalence of human papilloma virus (HPV) infections in oral squamous cell carcinomas: a retrospective analysis of 88 patients and literature overview. J Craniomaxillofac Surg 2014;42:1506–14Google Scholar
18Zivile, G, Janina, D, Irina, M, Saulius, C, Raisa, S, Aliaksandr, Z. Prevalence of human papillomaviruses in patients with head and neck squamous cell carcinoma in Lithuania and Belarus. J Med Virol 2014;86:531–5Google Scholar
19Al-Rajhi, N, Khafaga, Y, El-Husseiny, J, Saleem, M, Mourad, W, Al-Otieschan, A et al. Early stage carcinoma of oral tongue: prognostic factors for local control and survival. Oral Oncol 2000;36:508–14Google Scholar
20Bryne, M, Koppang, HS, Lilleng, R, Kjaerheim, A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol 1992;166:375–81Google Scholar
21Piccirillo, JF, Lacy, PD, Basu, A, Spitznagel, EL. Development of a new head and neck cancer-specific comorbidity index. Arch Otolaryngol Head Neck Surg 2002;128:1172–9Google Scholar
22Ribeiro, K, Kowalski, L, Latorre, M. Impact of comorbidity, symptoms, and patients’ characteristics on the prognosis of oral carcinomas. Arch Otolaryngol Head Neck Surg 2000;126:1079–85Google Scholar
23Ferlito, A, Rinaldo, A, Thomas Robbins, K, René Leemans, C, Shah, JP, Shaha, AR et al. Changing concepts in the surgical management of the cervical node metastasis. Oral Oncol 2003;39:429–35Google Scholar
24Greenberg, JS, El Naggar, AK, Mo, V, Roberts, D, Myers, JN. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Cancer 2003;98:508–15Google Scholar
25Shingaki, S, Takada, M, Sasai, K, Bibi, R, Kobayashi, T, Nomura, T et al. Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg 2003;185:278–84Google Scholar
26Woolgar, JA, Rogers, SN, Lowe, D, Brown, JS, Vaughan, ED. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol 2003;39:130–7Google Scholar
27Greenberg, JS, Fowler, R, Gomez, J, Mo, V, Roberts, D, El Naggar, AK et al. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 2003;97:1464–70Google Scholar
28Preuss, SF, Klussmann, JP, Semrau, R, Huebbers, C. Update on HPV-induced oropharyngeal cancer [in German]. HNO 2011;59:1031–7Google Scholar
29Fakhry, C, Westra, WH, Li, S, Cmelak, A, Ridge, JA, Pinto, H et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261–9Google Scholar
30Petrelli, F, Sarti, E, Barni, S. Predictive value of human papillomavirus in oropharyngeal carcinoma treated with radiotherapy: an updated systematic review and meta-analysis of 30 trials. Head Neck 2014;36:750–9Google Scholar