Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-20T08:33:40.209Z Has data issue: false hasContentIssue false
  • English
  • Français

Coronavirus-associated mucormycosis: different from sinonasal mucormycosis

Published online by Cambridge University Press:  06 July 2022

T Kataria Open the ORCID record for T Kataria [Opens in a new window] ,
S Sharma ,
P S Jat ,
S N Singh ,
M Grover Open the ORCID record for M Grover [Opens in a new window] ,
S Sharma ,
Y Agarwal  and
S Agarwal
T Kataria
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
S Sharma
Affiliation:
Medical Education Department, Jaipur, India
P S Jat
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
S N Singh*
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
M Grover
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
S Sharma
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
Y Agarwal
Affiliation:
Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur, India
S Agarwal
Affiliation:
Department of Otorhinolaryngology, Jawaharlal Nehru Medical College, Jaipur, India
*
Author for correspondence: Dr Shashank Nath Singh, Department of Otorhinolaryngology, Sawai Man Singh Medical College, Jaipur302004, Rajasthan, India E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To study unusual presentations of coronavirus-associated mucormycosis that are rarely seen in sinonasal mucormycosis cases.

Method

The data of 400 rhino-orbito-cerebral mucormycosis patients admitted to Sawai Man Singh Hospital, Jaipur, from May 2021 to June 2021, were retrospectively collected. The diagnosis of mucormycosis was made by histological examination of biopsy samples.

Results

Out of 400 patients, 62 had symptoms other than common symptoms of rhino-orbito-cerebral mucormycosis. Thirty-four patients had facial palsy, 19 complained of gum ulcers, 6 developed a cheek abscess, 2 complained of maggots in the nose along with common rhino-orbito-cerebral mucormycosis symptoms, and 1 had a cerebellar infarct.

Conclusion

Mucormycosis is a disease with various presentations, and coronavirus-associated mucormycosis has added unusual presentations to the existing list of manifestations of rhino-orbito-cerebral mucormycosis. In this coronavirus disease era, mucormycosis should always be considered as a diagnosis in patients with these unusual presentations.

Keywords

MucormycosisFacial PalsyCheekAbscess
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 12 , December 2022 , pp. 1296 - 1303
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr S Singh takes responsibility for the integrity of the content of the paper

References

Sharma, S, Grover, M, Bhargava, S, Samdani, S, Kataria, T. Post coronavirus disease mucormycosis: a deadly addition to the pandemic spectrum. J Laryngol Otol 2021;135:442–7CrossRefGoogle Scholar
SeyedAlinaghi, S, Afsahi, AM, MohsseniPour, M, Behnezhad, F, Salehi, MA, Barzegary, A et al. Late complications of COVID-19; a systematic review of current evidence. Arch Acad Emerg Med 2021;9:e14Google ScholarPubMed
Werthman-Ehrenreich, A. Mucormycosis with orbital compartment syndrome in a patient with COVID-19. Am J Emerg Med 2021;42:264.e5–8CrossRefGoogle Scholar
Yin, CH, Wang, C, Tang, Z, Zhang, SW, Wang, BS. Clinical analysis of 146 patients with critical severe acute respiratory syndrome in Beijing areas. Clin J Emerg Med 2004;1:12–14Google Scholar
Peeri, NC, Shrestha, N, Rahman, MS, Zaki, R, Tan, Z, Bibi, S et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol 2020;49:717–26CrossRefGoogle ScholarPubMed
Paltauf, A. Mycosis mucorina: a contribution to the knowledge of human thread fungus diseases [in German]. Virchows Arch Pathol Anat 1885;102:543–64CrossRefGoogle Scholar
Sravani, T, Uppin, SG, Uppin, MS, Sundaram, C. Rhinocerebral mucormycosis: pathology revisited with emphasis on perineural spread. Neurol India 2014;62:383–6Google ScholarPubMed
Yang, W, Cao, Q, Qin, L, Wang, X, Cheng, Z, Pan, A et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020;80:388–93CrossRefGoogle ScholarPubMed
Frater, JL, Hall, GS, Procop, GW. Histologic features of zygomycosis. Emphasis on perineural invasion and fungal morphology. Arch Pathol Lab Med 2001;125:375–8CrossRefGoogle ScholarPubMed
Rajeshwari, A, Gangadhara, SKS. Rhinocerebral mucormycosis: an unusual presentation. Am J Med Med Sci 2012;2:16–19Google Scholar
Bakshi, SS. An unusual cause for facial nerve palsy: mucormycosis. Int J Diabetes Dev Ctries 2016;36:385–8CrossRefGoogle Scholar
Mehta, R, Nagarkar, NM, Ksbs, KS, Ty, SS, Arora, RD, Aggarwal, A. Facial nerve palsy in COVID-19-associated mucormycosis patients: a case series. Cureus 2021;13:e19208Google ScholarPubMed
Ferguson, BJ. Mucormycosis of the nose and paranasal sinuses. Otolaryngol Clin North Am 2000;33:349–65CrossRefGoogle ScholarPubMed
Pecket, P, Schattner, A. Concurrent Bell's palsy and diabetes mellitus: a diabetic mononeuropathy? J Neurol Neurosurg Psychiatry 1982;45:652–5CrossRefGoogle ScholarPubMed
Galán, M, Jiménez-Altayó, F. Small resistance artery disease and ACE2 in hypertension: a new paradigm in the context of COVID-19. Front Cardiovasc Med 2020;7:588692CrossRefGoogle ScholarPubMed
Mohebbi, A, Jahandideh, H, Harandi, AA. Rare presentation of rhino-orbital-cerebral zygomycosis: bilateral facial nerve palsy. Case Rep Med 2011;2011:216404CrossRefGoogle ScholarPubMed
Manjunath, NM, Pinto, PM. Management of recurrent rhinomaxillary mucormycosis and nasal myiasis in an uncontrolled diabetic patient: a systematic approach. Int J Appl Basic Med Res 2018;8:122–5Google Scholar
Pathak, VK, Saxena, R, Awasthi, S, Gaur, S, Singh, SK. Rhinoorbitocerebral mucormycosis with maggots in a neglected diabetic patient. Indian J Otolaryngol Head Neck Surg 2018;70:156–8CrossRefGoogle Scholar
Thajeb, P, Thajeb, T, Dai, D. Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy. Scand J Infect Dis 2004;36:643–8CrossRefGoogle ScholarPubMed