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Co-N reaction – a new serological activity index – on Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

Makoto Ikeda ,
Sumiaki Tsuru ,
Toshihiro Ohmori ,
Satoshi Kitahara ,
Tetsuzo Inouye  and
Gerald B. Healy
Makoto Ikeda*
Affiliation:
Departments of Otolaryngology and Harvard Medical School, Boston, MA, USA.
Sumiaki Tsuru
Affiliation:
Departments of Microbiology, National Defense Medical College, Saitama, Harvard Medical School, Boston, MA, USA.
Toshihiro Ohmori
Affiliation:
Departments of Research Institute of Life Science, Snow Brand Milk Products Co. Ltd., Tochigi, Japan and the Harvard Medical School, Boston, MA, USA.
Satoshi Kitahara
Affiliation:
Departments of Otolaryngology and Harvard Medical School, Boston, MA, USA.
Tetsuzo Inouye
Affiliation:
Departments of Otolaryngology and Harvard Medical School, Boston, MA, USA.
Gerald B. Healy
Affiliation:
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.
*
Dr Makoto Ikeda, Head of Medical Divison, JMSDF Ozuki Air Base, Matsuya Shimonoseki-City, Yamguchi 750-11, Japan.
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Abstract

Cordyceps ophioglossoides is one of the Japanese old ’Kanpoh‘ drugs used for metrorrhagia as a decoction. We found that CO-N, a galactosaminoglycan from Cordyceps ophioglossoides, reacted with sera from patients with some collagen diseases. By using CO-N, we made a new serological activity index (CO—N reac tion). In the present study, we investigated CO-N reaction on patients with Wegener's granulomatosis (WG). The aggregation titres of CO-N (CO-N numbers) displayed a possible correlation with their clinical activity. CO-N reaction might also serve an important role in supporting the diagnosis of active WG and in helping to assess the degree of disease activity. The purpose of this report is to introduce this new serological activity index for Wegener's granulomatosis.

Keywords

Wegener's granulomatosisSerodiagnosisCollagen diseases
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 7 , July 1993 , pp. 607 - 610
Copyright
Copyright © JLO (1984) Limited 1993

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References

Ikeda, M, Tsuru, S., Shinomiya, N., Hara, M., Nakamura, H., Ohmori, T. (1989) A new immunological parameter E-082 – its application for rheumatoid arthritis. Therapeutic Research 10 (8) 571–574.Google Scholar
Kawaguchi, N., Ohmori, T., Takeshita, Y., Kawanichi, G., Katayama, S., Yamada, H. (1986 a) Occurrence of Gal-beta(1–3) Galnac-Ser/Thr in the linkage region of polygalactosamine containing fungal glycoprotein from Cordyceps ophioglossoides. Biochemical Biophysical Research Communications 140: 350–356CrossRefGoogle ScholarPubMed
Kawaguchi, N., Ohgane, N., Kawashima, N., Sugawara, S., Hirai, T., Takeshita, Y., Tsuru, S., Nomoto, K. (1986 b) Aggregation mechanism of sera from cancer patients by galactosaminoglycan (CO-N). Yakugaku Zasshi 6: 446–451x (in Japanese).CrossRefGoogle Scholar
Ohmori, X, Tamura, K., Tsuru, S., Nomoto, K. (1986) Anti-tumour activity of protein-bound polysaccharide from Cordyceps ophioglossoidesin mice. Japanese Journal of Cancer Research (Gann) 77: 1256–1263Google Scholar
Ohmori, T., Tamura, K., Takaoka, K., Sawai, T., Kawanishi, G., Yanahira, S., Tsuru, S., Nomoto, K. (1988 a) Component analysis of protein-bound polysaccharide (SN—C) from Cordyceps ophioglossoidesand its effect on syngeneic murine tumours. Chemical Pharmaceutical Bulletin 36: 4505–4511CrossRefGoogle Scholar
Ohmori, T, Tamura, K., Wakaiki, A., Kawanishi, G., Tsuru, S., Yadomae, T, Nomoto, K. (1988 b) Dissociation of a glucan fraction (CO-N) from protein-bound polyasccharide of Cordyceps ophioglossoidesand analysis of its anti-tumour effect. Chemical Pharmaceutical Bulletin 36: 4512–1518CrossRefGoogle Scholar
Ohmori, T. Tamura, K., Fukui, K., Kawanishi, G., Mitsuyama, M., Nomoto, K., Miyazaki, T. (1989) Isolation of galactosaminoglycan moiety (CO-N) from protein-bound polysaccharide of Cordyceps ophioglossoidesand its effects against murine tumours. Chemical Pharmaceutical Bulletin 37: 1019–1022CrossRefGoogle Scholar
Rasmussen, N., Petersen, J., Ralfkiaer, E., Avnstom, S., Wilk, A. (1988) Spontaneous and induced immunogloblin synthesis and anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis: relation to leukocyte subpopulation in blood and active lesions. Rheumatology International 8: 153–158CrossRefGoogle Scholar
Yamada, H., Kawaguchi, N., Ohmori, T, Takeshita, Y, Taneya, S.. Miyazaki, T. (1984 a) Structure and anti-tumour activity of an alkali-soluble polysaccharide from Cordyceps ophioglossoides. Carbohydrate Research 125: 107–115CrossRefGoogle Scholar
Yamada, H., Kawaguchi, N., Ohmori, T., Takeshita, Y, Taneya, S., Miyazaki, T. (1984 b) Structure of a galactosaminoglycan from Cordyceps ophioglossoides. Carbohydrate Research 125: 275–282CrossRefGoogle Scholar