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Cholarmphenicol ototoxicity

A Case Report

Published online by Cambridge University Press:  29 June 2007

S. Md. Iqbal
Affiliation:
Senior specialist in E.N.T.
C. B. P. Srivatsav
Affiliation:
Speech therapist and audiologist.

Abstract

A case of bilateral profound sensori-neural hearing loss following systemic administration of chloramphenicol is reported because of its rarity. The hearing loss was gradually progressive, involving one ear; and with a repeat course of the drug, the other ear too was involved. An idiosyncratic or allergic response to previous exposure to the drug may be the cause of the toxicity. One should be careful in prescribing the drug repeatedly; when this is done, the patient must be carefully observed for possible toxic effects.

Type
Clinical records
Copyright
Copyright © JLO (1984) Limited 1984

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References

Bull, T. R., Ransome, J. and Holden, H. B. (1978) Recent Advances in Otolaryngology. Churchill Livingstone. Edinburgh London and New York: p. 224.Google Scholar
D'Angelo, F. P., Patterson, W. C., and Morrow, R. C. (1967) Chloramphenicol. Topical Application in the Middle Ear. Archives of Otolaryngology, 85: 682684.CrossRefGoogle ScholarPubMed
Dwivedi, G. S. and Mehra, Y. N. (1978): Ototoxicity of Chloroquine Phosphate—A case Report. Journal of Laryngology and Otology, 92: 701703.CrossRefGoogle ScholarPubMed
Gargye, A. K. and Dutta, D. V. (1959): Nerve Deafness following Chloromycetin Therapy. Indian Journal of Paediatrics, 26: 265.CrossRefGoogle ScholarPubMed
Goodman, L. S. and Gilman, A. (1975) (Ed.) the Pharmacological Basis of Therapeutics. Fifth Edition. Macmillan publishing Co. Inc., New York: p. 1198.Google Scholar
Joy, R. J. T., Scalettar, R. and Sodee, D. B. (1960): Optic & peripheral neuritis, probable effect of prolonged chloramphenicol therapy. Journal of the American Medical Association, 173: 17311734.CrossRefGoogle ScholarPubMed
Proud, G. O., Mittelman, H. and Seiden, G. D. (1968) Ototoxicity of Topically Applied chloramphenicol. Archives of Otolaryngology, 87: 580587.CrossRefGoogle ScholarPubMed
Svenungsson, B., Bengtsson, E., Fluur, E. and Siegborn, J. (1976): Hearing Loss as a sequel to chloramphenicol and Ampicillin Treatment of Haemophilus influenza Meningitis. Scandinavian Journal of Infectious Diseases, 8: 175180.CrossRefGoogle Scholar