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Chloroquine ototoxicity—a reversible phenomenon?

Published online by Cambridge University Press:  29 June 2007

D. K. Mukherjee
D. K. Mukherjee
Affiliation:
Enugu, Nigeria
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Abstract

Summary

A BRIEF review of cranio-facial fibro-osseous lesions is given and 15 cases of fibrous dysplasia and ossifying fibroma are presented with clinical, radiological and histomorphological findings. After histological verification of the fibro-osseous nature of the process, 5 lesions were diagnosed on a radiological basis as fibrous dysplasia exhibiting diffuse (blending) margins, while the diagnosis of ossifying fibroma was given to 10 radiologically sharply-demarcated lesions. Both groups of lesions presented the same histomorphological features, although to a varying degree. Spheroidal calcifications, however, were identified in ossifying fibroma only, but not in all of these. Thus, the differential diagnosis of fibrous dysplasia versus ossifying fibroma rests on a radiological criterion after the histopathologist has verified the fibro-osseous nature of a lesion. The observation times varied from 1 ½ to 34 years. Two cases of fibrous dysplasia and 3 cases of ossifying fibroma recurred. In one case of fibrous dysplasia an osteosarcoma developed 33 years after irradiation. Pain was a, common symptom in the present material.

Type
Clinical records
Information
The Journal of Laryngology & Otology , Volume 93 , Issue 8 , August 1979 , pp. 809 - 815
Copyright
Copyright © JLO (1984) Limited 1979

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References

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