Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-26T10:07:59.825Z Has data issue: false hasContentIssue false
  • English
  • Français

A ‘chemical help’ in middle-ear surgery? A systematic review on sodium 2-mercaptoethanesulfonate

Published online by Cambridge University Press:  05 July 2021

A Moffa ,
V Fiore ,
L Sabatino ,
M Cassano ,
M Tarabichi ,
M Kapadia ,
V Rinaldi  and
M Casale
A Moffa*
Affiliation:
Unit of Otolaryngology – Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy Unit of Otolaryngology, University of Foggia, Italy
V Fiore
Affiliation:
Unit of Otolaryngology, University of Foggia, Italy
L Sabatino
Affiliation:
Unit of Otolaryngology – Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy
M Cassano
Affiliation:
Unit of Otolaryngology, University of Foggia, Italy
M Tarabichi
Affiliation:
Department of Otolaryngology, Tarabichi Stammberger Ear Sinus Institute, Dubai, United Arab Emirates Department of Otolaryngology, American Hospital Dubai, United Arab Emirates
M Kapadia
Affiliation:
Department of Otolaryngology, Tarabichi Stammberger Ear Sinus Institute, Dubai, United Arab Emirates
V Rinaldi
Affiliation:
Unit of Otolaryngology – Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy
M Casale
Affiliation:
Unit of Otolaryngology – Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy
*
Author for correspondence: Dr Antonio Moffa, Unit of Otolaryngology – Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Via Álvaro del Portillo, Rome 21-00128, Italy E-mail: [email protected] Fax: +39 06 22 54 11
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Sodium 2-mercaptoethanesulfonate (Mesna) has been proposed as a chemical aid in any surgical procedure, including cholesteatoma surgery. This review investigated the benefits and safety of Mesna during surgical management of cholesteatoma and adhesive otitis media.

Method

A systematic literature review was performed to identify clinical studies evaluating topical Mesna application during ear surgery (cholesteatoma or atelectasis). A qualitative analysis based on data extracted was conducted.

Results

From 27 articles, 5 retrospective studies were selected for a full analysis for a total of 607 patients (aged 5 to 72 years). Three studies evaluated cholesteatoma recidivism after Mesna application during cholesteatoma surgery, one study evaluated the surgical success rate of Mesna application for the treatment of atelectatic ears and adhesive otitis media, and one study evaluated potential ototoxicity of Mesna during cholesteatoma surgery. All the studies showed overall improvement in recurrence and residual cholesteatoma disease after Mesna application during surgery. Sensorineural hearing loss was not encountered after Mesna application.

Conclusion

Mesna application in cholesteatoma surgery could represent a valid and safe support tool during surgical treatment carried out both with microscopy and endoscopy. More studies are required to confirm these promising results.

Keywords

Sodium 2-MercaptoethanesulfonateMesnaTympanoplastyMastoidectomyDissection
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 8 , August 2021 , pp. 660 - 667
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr A Moffa takes responsibility for the integrity of the content of the paper

References

Clarke, SW, Lopez-Vidriero, MT, Pavia, D, Thomson, ML. The effect of sodium 2-mercapto-ethane sulphonate and hypertonic saline aerosols on bronchial clearance in chronic bronchitis. Br J Clin Pharmacol 1979;7:39–44CrossRefGoogle ScholarPubMed
Gressier, B, Lebegue, S, Brunet, C, Luyckx, M, Dine, T, Cazin, M et al. Pro-oxidant properties of methotrexate: evaluation and prevention by an anti-oxidant drug. Pharmazie 1994;49:679–81Google ScholarPubMed
Gressier, B, Lebegue, N, Brunet, C, Luyckx, M, Dine, T, Cazin, M et al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci 1995;17:76–80CrossRefGoogle ScholarPubMed
Berrigan, MJ, Marinello, AJ, Pavelic, Z, Williams, CJ, Struck, RF, Gurtoo, HL. Protective role of thiols in cyclophosphamide-induced urotoxicity and depression of hepatic drug metabolism. Cancer Res 1982;42:3688–95Google ScholarPubMed
Sener, G, Sehirli, O, Erkanli, G, Cetinel, S, Gedik, N, Yeğen, B. 2-Mercaptoethane sulfonate (MESNA) protects against burn-induced renal injury in rats. Burns 2004;30:557–6410.1016/j.burns.2004.02.008CrossRefGoogle ScholarPubMed
Casale, M, Di Martino, A, Salvinelli, F, Trombetta, M, Denaro, V. MESNA for chemically assisted tissue dissection. Expert Opin Investig Drugs 2010;19:699–707CrossRefGoogle ScholarPubMed
Kluyskens, P, Gillis, E, Nsabumukunzi, S. First observations on treatment of cholesteatoma with (N-acetyl)cysteine. Acta Otolaryngol 1979;87:362–5CrossRefGoogle ScholarPubMed
Zini, C, Bacciu, S, Gandolfi, A, Piazza, F, Pasanisi, E. University of Parma USOO6143797A 11. Patent number: 6,143,797 (45) Date of patent: 2000Google Scholar
Liberati, A, Altman, DG, Tetzlaff, J, Mulrow, C, Gøtzsche, PC, Ioannidis, JP et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009;62:e1–3410.1016/j.jclinepi.2009.06.006CrossRefGoogle ScholarPubMed
Guyatt, GH, Oxman, AD, Kunz, R, Atkins, D, Brozek, J, Vist, G et al. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol 2011;64:395–40010.1016/j.jclinepi.2010.09.012CrossRefGoogle ScholarPubMed
National Institute for Health and Care Excellence. Methods for the Development of NICE Public Health Guidance. London: National Institute for Health and Care Excellence (NICE), 2012Google Scholar
de la Torre, C, Villamor, P. Chemically assisted dissection with sodium 2-mercaptoethanesulfonate (Mesna) in the surgical management of pediatric cholesteatoma. Otol Neurotol 2019;40:645–5010.1097/MAO.0000000000002174CrossRefGoogle ScholarPubMed
Yilmaz, M, Goksu, N, Bayramoglu, I, Bayazit, YA. Practical use of MESNA in atelectatic ears and adhesive otitis media. ORL J Otorhinolaryngol Relat Spec 2006;68:195–810.1159/000091472CrossRefGoogle ScholarPubMed
Vincenti, V, Magnan, J, Saccardi, MS, Zini, C. Chemically assisted dissection by means of mesna in cholesteatoma surgery. Otol Neurotol 2014;35:1819–24CrossRefGoogle ScholarPubMed
Kalcioglu, MT, Cicek, MT, Bayindir, T, Ozdamar, OI. Effectiveness of MESNA on the success of cholesteatoma surgery. Am J Otolaryngol 2014;35:357–61CrossRefGoogle ScholarPubMed
Vincenti, V, Magnan, J, Zini, C. Cochlear effects of intraoperative use of Mesna in cholesteatoma surgery. Acta Biomed 2014;85:30–4Google ScholarPubMed
Carassiti, M, Di Martino, A, Centonze, A, Quattrocchi, CC, Caldaria, A, Agrò, F et al. Failed back surgery syndrome: a new strategy by the epidural injection of MESNA. Musculoskelet Surg 2018;102:179–8410.1007/s12306-017-0520-xCrossRefGoogle ScholarPubMed
Yung, M, Jacobsen, NL, Vowler, SL. A 5-year observational study of the outcome in pediatric cholesteatoma surgery. Otol Neurotol 2007;28:1038–40CrossRefGoogle ScholarPubMed
Ayache, S, Tramier, B, Strunski, V. Otoendoscopy in cholesteatoma surgery of the middle ear: what benefits can be expected? Otol Neurotol 2008;29:1085–90CrossRefGoogle Scholar
Tarabichi, M, Nogueira, JF. Functional endoscopic chronic ear surgery: a new horizon. Otolaryngol Clin North Am 2016;49:xvCrossRefGoogle ScholarPubMed
Jufas, N, Rubini, A, Soloperto, D, Alnoury, M, Tarabichi, M, Marchioni, D et al. The protympanum, protiniculum and subtensor recess: an endoscopic morphological anatomy study. J Laryngol Otol 2018;132:489–9210.1017/S0022215118000464CrossRefGoogle ScholarPubMed
Dixon, PR, James, AL. Evaluation of residual disease following transcanal totally endoscopic vs postauricular surgery among children with middle ear and attic cholesteatoma. JAMA Otolaryngol Head Neck Surg 2020;146:408–13CrossRefGoogle ScholarPubMed
Badr-el-Dine, M. Value of ear endoscopy in cholesteatoma surgery. Otol Neurotol 2002;23:631–510.1097/00129492-200209000-00004CrossRefGoogle ScholarPubMed
Marchioni, D, Soloperto, D, Rubini, A, Villari, D, Genovese, E, Artioli, F et al. Endoscopic exclusive transcanal approach to the tympanic cavity cholesteatoma in pediatric patients: our experience. Int J Pediatr Otorhinolaryngol 2015;79:316–22CrossRefGoogle ScholarPubMed
Aslıer, M, Erdag, TK, Sarioglu, S, Güneri, EA, Ikiz, AO, Uzun, E et al. Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients. Int J Pediatr Otorhinolaryngol 2016;82:73–710.1016/j.ijporl.2016.01.008CrossRefGoogle ScholarPubMed
Neudert, M, Lailach, S, Lasurashvili, N, Kemper, M, Beleites, T, Zahnert, T. Cholesteatoma recidivism: comparison of three different surgical techniques. Otol Neurotol 2014;35:1801–8CrossRefGoogle ScholarPubMed
Dogan, R, Eren, SB, Gedik, O, Yenıgun, A, Aydın, MS, Eser, B et al. Different concentrations of mesna application have an effect on the internal ear? Int J Pediatr Otorhinolaryngol 2018;109:31–5CrossRefGoogle ScholarPubMed
Marquet, J. My current cholesteatoma techniques. Am J Otol 1989;10:124–30Google ScholarPubMed