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Changes in expression of p53, proliferating cell nuclear antigen and bcl-2 in recurrent laryngeal cancer after radiotherapy

Published online by Cambridge University Press:  04 May 2006

B-J Lee ,
S-G Wang ,
H-J Roh ,
E-K Goh ,
K-M Chon  and
D-Y Park
B-J Lee
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
S-G Wang
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
H-J Roh
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
E-K Goh
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
K-M Chon
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea
D-Y Park
Affiliation:
Department of Pathology, College of Medicine and the Medical Research Institute, Pusan National University, Busan, Korea
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Abstract

The biological changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated differences in the expression of p53, proliferating cell nuclear antigen (PCNA) and bcl-2 in laryngeal cancer specimens before radiotherapy and in recurrent laryngeal cancer specimens following radiotherapy in the same patients. The authors investigated the expression of p53, PCNA and bcl-2 by immunohistochemical stain in 30 specimens from 15 patients with primary laryngeal cancer and recurrent laryngeal cancer after radiotherapy.

The expression of p53 protein was significantly different in laryngeal cancer before radiotherapy (4/15, 26.7 per cent) compared with recurrent laryngeal cancer after radiotherapy (8/15, 53.3 per cent) (p < 0.05). The PCNA index was also significantly different in laryngeal cancer specimens before radiotherapy (mean, 11.9 per cent) compared with recurrent laryngeal cancer after radiotherapy (mean, 18.0 per cent) (p < 0.05). However, there was no statistically significant alteration of bcl-2 expression in primary compared with recurrent laryngeal cancer. The expression of p53 and PCNA increased in recurrent laryngeal cancers after radiotherapy, compared with that in laryngeal cancers before radiotherapy. Recurrent laryngeal cancers arising following radiotherapy became biologically aggressive.

Keywords

Laryngeal NeoplasmsP53 GenesProliferating Nuclear Cell AntigenBcl-2 GenesRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 7 , July 2006 , pp. 579 - 582
Copyright
2006 JLO (1984) Limited

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