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The changes in different symptom scores during subcutaneous immunotherapy in Chinese house dust mite allergic patients: a two-year, observational study

Published online by Cambridge University Press:  24 January 2019

Y Tu ,
H Zhang ,
L Zhao ,
P Jin ,
X Zi ,
T Li ,
L Shi  and
L Zhi
Y Tu
Affiliation:
School of Medicine, Shandong University, Jinan, People's Republic of China
H Zhang
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital of Shandong University, Jinan, People's Republic of China
L Zhao
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital of Shandong University, Jinan, People's Republic of China
P Jin
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital of Shandong University, Jinan, People's Republic of China
X Zi
Affiliation:
School of Medicine, Shandong University, Jinan, People's Republic of China
T Li
Affiliation:
School of Medicine, Shandong University, Jinan, People's Republic of China
L Shi
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital of Shandong University, Jinan, People's Republic of China
L Zhi*
Affiliation:
Department of Otolaryngology, Central Hospital of Zibo, People's Republic of China
*
Author for correspondence: Dr Lili Zhi, Department of Otolaryngology, Central Hospital of Zibo, 55 Liuquan Road, Zibo 255031, Shandong Province, People's Republic of China E-mail: [email protected]
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Abstract

Background

Subcutaneous immunotherapy is an effective and safe treatment for allergic rhinitis and allergic asthma. Different symptom scores are used to evaluate the efficacy of subcutaneous immunotherapy in clinical trials.

Method

A total of 58 allergic rhinitis patients sensitised to house dust mites, with or without mild asthma, were included. Symptom score, medication score, visual analogue scale score and quality of life were assessed before and after 6, 12 and 24 months of subcutaneous immunotherapy.

Results

After two years of subcutaneous immunotherapy, asthma symptom scores nearly reached zero, whereas the scores remained higher for nasal symptoms. The changes in asthma symptom scores were markedly different (p < 0.05) and occurred faster than the changes in nasal symptom scores when compared between monosensitised and polysensitised groups. Significant reductions in visual analogue scale score and medication score were demonstrated after subcutaneous immunotherapy.

Conclusion

Two-year subcutaneous immunotherapy with house dust mite vaccine is an effective treatment for both monosensitised and polysensitised allergic patients. The changes in asthma symptom scores were markedly different and occurred quicker than the changes in nasal symptom scores in Chinese house dust mite allergic patients.

Keywords

ImmunotherapyRhinitis, AllergicAsthmaDermatophagoides PteronyssinusDermatophagoides Farinae
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 3 , March 2019 , pp. 213 - 219
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr L Zhi takes responsibility for the integrity of the content of the paper

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