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Case report of a p16INK4A-positive branchial cleft cyst

Published online by Cambridge University Press:  25 May 2015

T McLean ,
C Iseli ,
D Amott  and
M Taylor
T McLean
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Austin Hospital, Heidelberg, Melbourne
C Iseli
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Austin Hospital, Heidelberg, Melbourne
D Amott*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Austin Hospital, Heidelberg, Melbourne Department of Otolaryngology-Head and Neck Surgery, The Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia
M Taylor
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Austin Hospital, Heidelberg, Melbourne
*
Address for correspondence: Dr D Amott Department of Otolaryngology-Head and Neck Surgery, The Royal Melbourne Hospital, 300 Grattan St Parkville, Melbourne 3052, Victoria, Australia Fax: +61 3 9375 2486 E-mail: [email protected]
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Abstract

Objective:

To report the occurrence of a concurrent oropharyngeal papilloma and branchial cleft cyst linked by p16INK4A and human papillomavirus immunohistochemistry.

Case report:

A 42-year-old woman presented with a 1-month history of a left lateral neck mass. Contrast enhanced computed tomography showed a hypodense lesion 20 mm in diameter anteromedial to the left sternocleidomastoid muscle. Ultrasound-guided fine needle aspiration suggested a branchial cleft cyst. Panendoscopy was performed at the time of neck mass removal, and a papillomatous lesion was removed from the left hypopharynx. Histopathological analysis showed the neck lesion to be a branchial cyst containing lymphoid tissue, and the oral lesion to be a squamous papilloma. Immunohistochemical analysis showed both the branchial cleft cyst and papilloma to be positive for p16INK4A expression and human papillomavirus DNA.

Conclusion:

Histological and immunohistochemical analyses support the cystic transformation of lymph nodes, or the ‘Inclusion Theory’, as the aetiology of branchial apparatus anomalies, and raise the possibility that human papillomavirus infection may play a much larger role in disease of the head and neck than previously supposed.

Keywords

Papillomaviridaep16INK4ABranchioma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 6 , June 2015 , pp. 611 - 613
Copyright
Copyright © JLO (1984) Limited 2015 

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References

1Golledge, J, Ellis, H. The aetiology of lateral cervical (branchial) cysts: past and present theories. J Laryngol Otol 1994;108:653–9CrossRefGoogle ScholarPubMed
2Glosser, JW, Pires, CA, Feinberg, SE. Branchial cleft or cervical lymphoepithelial cysts: etiology and management. J Am Dent Assoc 2003;134:81–6CrossRefGoogle ScholarPubMed
3Bhaskar, SN, Bernier, JL. Histogenesis of branchial cysts; a report of 468 cases. Am J Pathol 1959;35:407–43Google ScholarPubMed
4Chandler, JR, Mitchell, B. Branchial cleft cysts, sinuses, and fistulas. Otolaryngol Clin North Am 1981;14:175–86CrossRefGoogle ScholarPubMed
5Shinkwin, C, Whitfield, BC, Robson, AK. Branchial cysts: congenital or acquired? Ann R Coll Surg Engl 1991;73:379–80Google ScholarPubMed
6D'Souza, G, Kreimer, AR, Viscidi, R, Pawlita, M, Fakhry, C, Koch, WM et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944–56CrossRefGoogle ScholarPubMed
7Adelstein, DJ, Ridge, JA, Gillison, ML, Chaturvedi, AK, D'Souza, G, Gravitt, PE et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9–10, 2008 Washington, D.C. Head Neck 2009;31:1393–422CrossRefGoogle Scholar
8Benson, MT, Dalen, K, Mancuso, AA, Kerr, HH, Cacciarelli, AA, Mafee, MF. Congenital anomalies of the branchial apparatus: embryology and pathologic anatomy. Radiographics 1992;12:943–60CrossRefGoogle ScholarPubMed
9Little, JW, Rickles, NH. The histogenesis of the branchial cyst. Am J Pathol 1967;50:533–47Google ScholarPubMed
10Maran, AG, Buchanan, DR. Branchial cysts, sinuses and fistulae. Clin Otolaryngol Allied Sci 1978;3:77–92CrossRefGoogle ScholarPubMed
11Pai, RK, Erickson, J, Pourmand, N, Kong, CS. p16(INK4A) immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx. Cancer 2009;117:108–19Google ScholarPubMed
12Nielsen, GP, Stemmer-Rachamimov, AO, Shaw, J, Roy, JE, Koh, J, Louis, DN. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab Invest 1999;79:1137–43Google ScholarPubMed