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Budesonide nasal spray as prophylactic treatment after polypectomy

(A double blind clinical trial)

Published online by Cambridge University Press:  29 June 2007

S. Hartwig*
Affiliation:
ENT Clinic, Central Hospital, Falun, Sweden.
M. Lindén
Affiliation:
ENT Clinic, Central Hospital, Falun, Sweden.
A.-K. Vargö
Affiliation:
ENT Clinic, Central Hospital, Falun, Sweden.
N. Lindqvist
Affiliation:
Department of Clinical Research, A B Draco, Lund, Sweden.
*
Styrbjörn Hartwig, ENT-Clinic, Falu hospital, S-791 82 FALUN, Sweden.

Abstract

Summary

This double-blind parallel-group study compared the effect of budesonide with placebo, in the prophylaxis of nasal polyp recurrence after evulsion. Seventy-three patients with first time or recurrent polypectomy were enrolled. At revisits 3 and 6 months after evulsion, the budesonide-treated patients had significantly lower polyp scores than the placebo-treated patients. Only patients with recurrent nasal polyposis benefited from the budesonide treatment, whereas no effect was evident in patients with first time evulsion

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 1988

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References

Balle, V. H., Pedersen, U. and Engby, B. (1980) Allergic perennial and non-allergic vasomotor rhinitis treated with budesonide nasal spray. Rhinology, 18: 135142.Google ScholarPubMed
David, S. D. and Berkowitz, J. S. (1969) Ocular effects of topical and systemic corticosteroids. The Lancet, July 19, 149151.CrossRefGoogle ScholarPubMed
Dingsör, G., Kramer, J., Olsholt, R. and Söderström, T. (1985) Flunisolide nasal spray 0. 025 per cent in the prophylactic treatment of nasal polyposis after polypectomi. Rhinology, 23: 4959.Google Scholar
Drake-Lee, A. B., Lowe, D., Swanston, A. and Grace, A. (1984) Clinical profile and recurrence of nasal polyps. Journal of Laryngology and Otology, 98: 783793.CrossRefGoogle ScholarPubMed
Drettner, B., Ebbesen, A. and Nilsson, M. (1982) Prophylactive treatment with flunisolide after polypectomy. Rhinology, 20: 149158.Google ScholarPubMed
Karlsson, G. and Rundcrantz, H. (1982) A randomized trial of intranasal beclomethasone dipropionate after polypectomy. Rhinology, 20: 144148.Google ScholarPubMed
Löfkvist, T. and Svensson, G. (1976) Treatment of vasomotor rhinitis with intranasal beclomethasone dipropionate (BecotideR). Results from a double-blind crossover study. Acta Allergologica, 31: 227238.CrossRefGoogle Scholar
Pipkorn, U. and Rundcrantz, H. (1982) Budesonide and beclomethasone dipropionate in hay fever—a single-blind comparison. European Journal of Respiratory Diseases, 63: 211220.Google Scholar
Vilsvik, J. S., Jenssen, A. O. and Walstad, R. (1975) The effect of beclomethasone dipropionate aerosol on allergen induced nasal stenosis. Clinical Allergy, 5: 291294.CrossRefGoogle ScholarPubMed