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Bronchial changes in airborne tularemia

Published online by Cambridge University Press:  29 June 2007

Hannu Syrjälä ,
Seppo Sutinen ,
Kalevi Jokinen ,
Pentti Nieminen ,
Tuula Tuuponen  and
Aimo Salminen
Hannu Syrjälä*
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
Seppo Sutinen
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
Kalevi Jokinen
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
Pentti Nieminen
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
Tuula Tuuponen
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
Aimo Salminen
Affiliation:
Departments of Medicine, Pathology, Otolayngology and Medical Microbiology, University of Oulu, Oulu; Oulaskangas Hospital, Oulainen; and Päivärinne Hospital, Jokirinne, Finland.
*
Hannu Syrjälä, M.D., Department of Medicine, Oulu University Central Hospital, Kajaanintie 50 SF-90220 Oulu 22, Finland.
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Abstract

We describe seven typhoidal tularemia patients without ulcers or lymphadenopa-thy, who underwent diagnostic bronchoscopy. Four patients had had obvious airborne exposure to F. tularensis during farming activities, and the remaining three had respiratory symptoms also. Bronchoscopical findings were pathological in all cases, varying from local to diffuse haemorrhagic inflammation; in one case a granulomatous tumour was seen. Early histopathological changes in three biopsies consisted of haemorrhagic oedema progressing to a non-specific inflammatory reaction, which could still be found 45 days after the onset of symptoms. Granulomatous inflammation, indistinguishable from tuberculosis or sarcoidosis, was seen in four biopsies from two patients, three to seven months after the onset. Most patients had radiographic hilar enlargement. We conclude that transmission of typhoid tularemia usually occurs through inhalation leading to bronchial changes, which correspond skin ulcerations in ulcero-glandular tularemia, the hilar enlargement corresponding to the lymph node component. We emphasize that usage of the term ‘typhoidal’ tularemia should be discontinued. Instead, tularemia transmitted through inhalation should be called pulmonary or respiratory.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 10 , October 1986 , pp. 1169 - 1176
Copyright
Copyright © JLO (1984) Limited 1986

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