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Autoimmune inner ear disease: A treatment update

Published online by Cambridge University Press:  27 May 2011

T. J. Yoo ,
J. J. Shea ,
J. Per Lee ,
A. Shulman ,
Y. Yazawa ,
R. Floyd ,
C. Y. Kuo ,
B. McCabe  and
G. Gardner
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Extract

McCabe (1979) described 18 cases of sensorineural deafness having clinical and laboratory features suggestive of an auto-immune etiology. This condition was characterized by a prolonged period of pro-gressive deafness over weeks or months, rather than hours, days or years. It is usually bilateral, asymmetrical and the cochlear is always involved. Other features of this disorder are facial paralysis and vestibular dysfunction. Tissue destruction of the tympanic membrane and middle ear and mastoid may also occur. These responded well to a high dose of steroid therapy and cyclophosphamide. A total of 42 cases of this disorder were diagnosed in McCabe's series as of January, 1982 (McCabe and Harker, 1982). Two-thirds of the patients had vestibular symptoms of low grade without spells and the reduction in caloric responses paralleled the hearing loss.

Type
Session IV. Clinical Concepts of Tinnitus (Chairman: M. Ronis)
Information
The Journal of Laryngology & Otology , Volume 98 , supplement S9: Proceedings of the II International Tinnitus Seminar. New York, 10 and 11 June 1983 , June 1984 , pp. 220 - 227
Copyright
Copyright © JLO (1984) Limited 1984

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References

1.Hughes, G. B., Kinney, S. E. and Barna, B. P. et al. (1982) Autoimmune activity in Cogan's syndrome: a preliminary report. Annual Meeting of the American Neurological Society, May 1982, Palm Beach, Florida.Google Scholar
2.McCabe, B. (1979) Autoimmune sensorineural hearing loss. Annals of Otology, Rhinology and Laryngology, 88: 585–589.CrossRefGoogle ScholarPubMed
3.Mccabe, B. and Harker, L. (1982) Features of AISHL presented, Think-tank Meeting on AISHL sponsored by National Hearing Association, May 1982, Palm Beach, Florida.Google Scholar
4.Soborg, M. (1971) The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man in vitro methods in cell mediated immunity, edited by Bloone, B. R. and , P. R.New York and London, Glade: 289–296. Academic Press.CrossRefGoogle Scholar
5.Wilson, M. B., Roger, L. K. and Stewart, I. A. (1981) Autoimmune Sensorineural Deafness: Case Report. The Mew Zealand Medical Journal, 697: 414–415.Google Scholar
6.Yoo, T. J., Stuart, J. M., Kang, A. H. et al. (1982) Type II collagen autoimmunity in Otosclerosis and Menière's disease. Science, 217: 1153–1155.CrossRefGoogle ScholarPubMed